Identification of a Hydroxypyrimidinone Compound (<b>21</b>) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure by Wei Meng (505670)

“…Due to the increased polarity at C2, the permeability for these compounds decreased. Further adjustment of the polarity by replacing the N1 2,6-dimethoxyphenyl group with a 2,6-diethylphenyl group and reoptimization for the potency of the C5 pyrroloamides resulted in potent compounds with improved permeability. …”

Identification of a Hydroxypyrimidinone Compound (<b>21</b>) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure by Wei Meng (505670)

“…Due to the increased polarity at C2, the permeability for these compounds decreased. Further adjustment of the polarity by replacing the N1 2,6-dimethoxyphenyl group with a 2,6-diethylphenyl group and reoptimization for the potency of the C5 pyrroloamides resulted in potent compounds with improved permeability. …”

Identification of a Hydroxypyrimidinone Compound (<b>21</b>) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure by Wei Meng (505670)

“…Due to the increased polarity at C2, the permeability for these compounds decreased. Further adjustment of the polarity by replacing the N1 2,6-dimethoxyphenyl group with a 2,6-diethylphenyl group and reoptimization for the potency of the C5 pyrroloamides resulted in potent compounds with improved permeability. …”

Developmental regulation of the decrease in adhesion. by Marco Tarantola (102609)

Excessive LF4A kinase activity shortens cilia and decreases IFT. by Yu-Yang Jiang (7036916)

Photo-affinity labelling and biochemical analyses identify the target of trypanocidal simplified natural product analogues by Lindsay B. Tulloch (1266861)

“…<div><p>Current drugs to treat African sleeping sickness are inadequate and new therapies are urgently required. As part of a medicinal chemistry programme based upon the simplification of acetogenin-type ether scaffolds, we previously reported the promising trypanocidal activity of <b>compound 1</b>, a bis-tetrahydropyran 1,4-triazole (B-THP-T) inhibitor. …”

Image5_The G protein biased serotonin 5-HT2A receptor agonist lisuride exerts anti-depressant drug-like activities in mice.JPEG by Vladimir M. Pogorelov (133492)

“…Despite these benefits, the hallucinogenic actions of these drugs at the serotonin 2A receptor (5-HT2AR) limit their clinical use in diverse settings. …”

Dosing analysis of the YFV vaccine (subcutaneous route) in interferon-1 receptor knockout mice (A129). by Ana C. Vicente Santos (11649118)

Down-regulation of VCAN or THBS2 decreased the cell proliferation in A549 cells. by Tzu-Yang Weng (2938080)

Table_1_Effectiveness of Improved Use of Chewing Gum During Capsule Endoscopy in Decreasing Gastric Transit Time: A Prospective Randomized Controlled Study.XLS by Liang Huang (114017)

“…<p>Background/Aim: Chewing gum throughout small bowel capsule endoscopy (SBCE) increases completion rates (CRs) but decreases small bowel transit time (SBTT) and diagnostic yield (DY). …”

Table_1_Effectiveness of Improved Use of Chewing Gum During Capsule Endoscopy in Decreasing Gastric Transit Time: A Prospective Randomized Controlled Study.XLS by Liang Huang (114017)

“…<p>Background/Aim: Chewing gum throughout small bowel capsule endoscopy (SBCE) increases completion rates (CRs) but decreases small bowel transit time (SBTT) and diagnostic yield (DY). …”

Data Sheet 1_Lack of association between genetic variations in CYP3A5 and blood pressure or hypertension risk in the UK biobank.pdf by Pia Leibold (21390134)

“…While some previous studies reported that CYP3A5 variants were associated with decreased blood pressure and risk of HTN, others reported no associations. …”

A Unique Modification of the Eukaryotic Initiation Factor 5A Shows the Presence of the Complete Hypusine Pathway in <em>Leishmania donovani</em> by Bhavna Chawla (176976)

“…<div><p>Deoxyhypusine hydroxylase (DOHH) catalyzes the final step in the post-translational synthesis of an unusual amino acid hypusine (<em>N</em>^€-(4-amino-2-hydroxybutyl) lysine), which is present on only one cellular protein, eukaryotic initiation factor 5A (eIF5A). We present here the molecular and structural basis of the function of DOHH from the protozoan parasite, <em>Leishmania donovani,</em> which causes visceral leishmaniasis. …”

Risk assessment for hospital admission in patients with COPD; a multi-centre UK prospective observational study by Jilles M. Fermont (3746068)

“…In total, 291 of 714 individuals experienced 762 hospitalised AECOPD during five-year follow up. Poorer performance of SPPB was associated with both higher rate (IRR 1.08 per 1 point decrease, 95% CI 1.01 to 1.14) and increased length of stay (IRR 1.18 per 1 point decrease, 95% CI 1.10 to 1.27) for hospitalised AECOPD. …”

P-Rex-deficient Purkinje neurons have normal passive membrane properties and basal synaptic transmission. by Claire Jackson (362873)

Hypoxia and Cobalt decrease AQP5 mRNA by down-regulating AQP5 transcription. by Jitesh D. Kawedia (384551)

Irbesartan Decreases ¹⁴C-FDG and ^99mTc-annexin A5 Accumulation Levels. by Yan Zhao (58882)

Subjects:

miR-146a and miR-155 levels decrease at the convalescent stage in patients with <i>V</i>. <i>cholerae</i> O1 infection. by Aziz Bitar (257322)

Amygdala voxel correlations with ACC whose values <i>decrease</i> as symptoms of post-combat emotional distress increase. by Tom Brashers-Krug (762715)

“…Threshold for significance was a <i>z</i>-score < -5.39. Coronal slices through the brain at y = 4, 2, 0, -2, -4, -6, and -8 mm showing the amygdala bilaterally. …”

ACC voxel correlations with amygdala whose values <i>decrease</i> as symptoms of post-combat emotional distress increase. by Tom Brashers-Krug (762715)

“…Threshold for significance was a <i>z</i>-score < -5.39. Only values within the ACC ROI are shown. …”