Identification of a Hydroxypyrimidinone Compound (<b>21</b>) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure by Wei Meng (505670)

“…Due to the increased polarity at C2, the permeability for these compounds decreased. Further adjustment of the polarity by replacing the N1 2,6-dimethoxyphenyl group with a 2,6-diethylphenyl group and reoptimization for the potency of the C5 pyrroloamides resulted in potent compounds with improved permeability. …”

Identification of a Hydroxypyrimidinone Compound (<b>21</b>) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure by Wei Meng (505670)

“…Due to the increased polarity at C2, the permeability for these compounds decreased. Further adjustment of the polarity by replacing the N1 2,6-dimethoxyphenyl group with a 2,6-diethylphenyl group and reoptimization for the potency of the C5 pyrroloamides resulted in potent compounds with improved permeability. …”

Identification of a Hydroxypyrimidinone Compound (<b>21</b>) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure by Wei Meng (505670)

“…Due to the increased polarity at C2, the permeability for these compounds decreased. Further adjustment of the polarity by replacing the N1 2,6-dimethoxyphenyl group with a 2,6-diethylphenyl group and reoptimization for the potency of the C5 pyrroloamides resulted in potent compounds with improved permeability. …”

The decrease in hBMVEC death is associated with reduced activation of Caspase-3. by Simona F. Spampinato (773594)

N100 amplitude decrease during 1 Hz-rTMS. by Christian Helfrich (297785)

“…Electrodes C3, CP3’ and CP5’ were pooled. <i>Left</i>: TMS-evoked N100 amplitude continuously decreased during the stimuli 1–500. …”

Hsp90 interacts with BMS1 and decreased Hsp90 function compromises 80S ribosome and polysome stability at 16°C. by Eric A. Franzosa (130063)

SEM images of the samples (a) virgin sample (b) 0.4 wt. % <i>f-MWCNTs</i> (c) 0.5 wt. % <i>f—MWCNTs</i>. by Shaban Gul (14309526)

Image_5_A Satellite dsRNA Attenuates the Induction of Helper Virus-Mediated Symptoms in Aspergillus flavus.JPEG by Yinhui Jiang (6520757)

<i>drp2b</i> shows increased ROS and decreased <i>PR1</i> mRNA to living <i>Pto</i> in a T3SS-independent manner. by John M. Smith (676719)

Hypothetical scenario of what is happening at the epithelial lining of the small intestine at the acute phase of <i>V</i>. <i>cholerae</i> infection. by Aziz Bitar (257322)

“…<p><i>V</i>. <i>cholerae</i> is a Gram(-), flagellated bacterium that secretes several soluble factors, e.g. cholera toxin and <i>V</i>. …”

Postnatal decrease in PV+ cortical interneurons in Fgfr1 mutant mice. by Karen Müller Smith (613941)

“…<p>PV and GFP immunostaining in 8 week old <i>Fgfr1^f/f;Gad67-GFP+</i> control (<b>A</b>, n = 5) and <i>Fgfr1^f/f;hGFAP-Cre;Gad67-GFP+</i> mutant mice (<b>B</b>, n = 9). …”

Citrulline as a nutraceutical protects against eCM. by Irene Gramaglia (6439613)

Local inhibition of nitrergic activity in tenotomized rats accelerates muscle regeneration by increasing fiber area and decreasing central core lesions by A.D. Seabra (6515330)

“…<div><p>Muscular atrophy is a progressive degeneration characterized by muscular proteolysis, loss of mass and decrease in fiber area. …”

Decrease in IE expression by HCMV-targeting CRISPR/Cas9 systems. by Janina Gergen (4856863)

SUI-sEVs decreased the migration ability of primary cultured fibroblasts. by Xiaoyan Sun (28501)

Table_5_Quantitative Ubiquitinomics Revealed Abnormal Ubiquitinated ATP7A Involved in Down-Regulation of ACTH in Silent Corticotroph Adenomas.xls by Sida Zhao (6005147)

Analysis of AMPA-R mediated EPSCs (aEPSCs) at CA1 synapses in hippocampal slices from P10 mice ICV injected at P1, P3, and P5 with saline or GR1. by Nicole M. Lykens (3727072)

“…<b>(d)</b> Rectification index of aEPSC amplitude was moderately decreased after SMO treatment (n = 8; p = 0.017). …”

Lethal dose of ZIKV infection in A129 mice by intravenous injection. by Ana C. Vicente Santos (11649118)

Loss of Fmrp leads to decreased neuronal differentiation but increased astrocyte differentiation. by Yuping Luo (147790)

“…Data are presented as mean ± SEM; *, p<0.05, **, p<0.01, ***, p<0.01, Student's t-test.…”

Effects of FE and RUD wrist postures on the mean carpal tunnel depth within each quartile. by Drew A. Anderson (14197446)