The first-in-human study to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of the factor XI monoclonal antibody SHR-2004 in healthy subjects by Tingting Ma (228102)

“…FXI activity decreased, and the activated partial thromboplastin time (APTT) was prolonged after i.v. and s.c. administration in a dose- and time-dependent manner. …”

AE treatment induces autophagy, and inhibits angiogenesis and Hif-1α expression in xenografted tumors. by Alok De (446321)

“…C. Representative photograph of a Western blot showing increased expression of LC3B-II in AE treated group. β-actin was used as a control for each blot. …”

Forward scores follow exponential tails with constant <i>λ</i>. by Sean R. Eddy (5840)

“…Variation in is represented by plotting quartiles (black bars) and most extreme outliers (grey triangles) in addition to the means. approaches the conjectured log 2 as fitted tail mass decreases, but beyond a certain point, variance increases. …”

Increasing dead cell burden in wounds resulted in increased pro-inflammatory cytokine levels. by Savita Khanna (252283)

“…Data (mean ±SD, n = 5) are presented as <i>pg</i> cytokine per <i>mg</i> wound tissue. *, <i>p</i><0.05 compared to IgG treated control side.…”

Inhibition of the Hedgehog pathway partially rescues pancreas formation in pancreas with activated β-catenin signaling. by Jose Luis Muñoz-Bravo (3220134)

“…The boxed areas are shown at higher magnification in the adjacent panels (A' and B'). (C) Fold change and p-values from upregulated components of the hedgehog pathway in E13.5 <i>Pdx1-Cre; Ctnnb1</i>^{<i>tm1Mmt/+</i>} pancreas observed in microarray analysis. …”

Optimisation of read depth, DNA quantity, and unique alternate observation threshold. by Melinda L. Tursky (20790436)

“…<p>A: The detection rate of reference standard variants ranging from 0.0008 to 0.1 VAF at 500-5,000 × depth. …”

Departures from the balance of excitation and inhibition do not effect assembly formation. by Lisandro Montangie (8816753)

“…<p>Mean clustering coefficient, mean global efficiency and modularity versus the inhibitory multiplicative factor <i>δ</i>_inh = {0.5, 0.8, 1.2, 1.5}, which scales the overall inhibitory matrix (see <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1007835#sec012" target="_blank">Methods</a>). …”

Secreted Bacterial Effectors That Inhibit Host Protein Synthesis Are Critical for Induction of the Innate Immune Response to Virulent <em>Legionella pneumophila</em> by Mary F. Fontana (229800)

“…Upon infection of macrophages with virulent <em>L. pneumophila</em>, these five effectors caused a global decrease in host translation, thereby preventing synthesis of IκB, an inhibitor of the NF-κB transcription factor. …”

Data_Sheet_1_Non-restorative Sleep Caused by Autonomic and Electroencephalography Parameter Dysfunction Leads to Subjective Fatigue at Wake Time in Shift Workers.PDF by Sofya Gorlova (6295268)

“…The results indicated that the subjects with high fatigue on the VAS at wake time exhibited (1) a decrease in deep non-rapid eye movement (NREM) (stageN3) sleep duration in the first sleep cycle; (2) a decrease in REM latency; (3) a decrease in ultra-slow and delta EEG powers, particularly from 30 to 65 min after sleep onset; (4) a decrease in the total power of HRV, particularly from 0 to 30 min after sleep onset; (5) an increase in the very low frequency component of HRV; and (6) a smaller increase in the distal-proximal gradient of skin temperature, than those of the subjects with low fatigue levels. …”

Effect of TNF-α on apoptosis in human eosinophils. by Hannu Kankaanranta (23356)

“…In (G and H) figures in top right corner represent percentages of Annexin-V positive cells (FITC+/PI- and FITC+/PI+). In (I) is shown the effect of neutralising TNF-α (A-TNF-α) antibody (5 µg/ml) on the inhibition of apoptosis induced by TNF-α. …”

Data_Sheet_1_Developmental Changes in ANS Precision Across Grades 1–9: Different Patterns of Accuracy and Reaction Time.pdf by Sergey Malykh (8395728)

“…<p>The main aim of this study was to analyze the patterns of changes in Approximate Number Sense (ANS) precision from grade 1 (mean age: 7.84 years) to grade 9 (mean age: 15.82 years) in a sample of Russian schoolchildren. …”

<i>Tcf21</i> promoter mutagenesis analysis. by Ramji K. Bhandari (136008)

“…Bars with asterisks are significantly different from −0.5 kb control promoter. (B) Promoter activity decreased with the length of the promoter. …”

Tg9949 mice are prone to neurological dysfunction but do not spontaneously generate prions. by David W. Colby (254454)

Similarity diagrams for the evaluation of M1, M2 and ANN precision. by Thomas Schmid (428873)

“…S7</a>). <b>D)</b> Distribution of data points from modeled spectra with τ ratios <5 (black ♦) is similar to the distribution of data points from measured spectra (blue •) obtained in the absence of forskolin or nystatin. …”

Supplementary Material for: IL-1 Mediates Tissue-Specific Inflammation and Severe Respiratory Failure in COVID-19 by Renieris G. (12527941)

In vitro characterization of MSCs from rats with adenine nephropathy. by Barbara Mara Klinkhammer (542578)

“…<p>(A) CKDsev-AD-MSC have a decreased proliferation capacity (cell population doubling time 116.1±57.7 h (n = 6) vs. 43±8.2 h in H-MSC (n = 5); p = 0.02). …”

Radical Quantum Yields from Formaldehyde Photolysis in the 30 400–32 890 cm^–1 (304–329 nm) Spectral Region: Detection of Radical Photoproducts Using Pulsed Laser Photoly... by Cheryl Tatum Ernest (2067766)

“…The resulting radical quantum yields agree well with previous experimental studies and the current JPL recommendation but show greater wavelength dependent structure. A significant decrease in the quantum yield was observed for the 5₀¹ + 1₀¹4₀¹ combination band centered at 31 125 cm^–1. …”

Flexible, Suturable, and Leak-free Scaffolds for Vascular Tissue Engineering Using Melt Spinning by Julia Fernández-Pérez (16649098)

“…The scaffolds with a higher angle between fibers showed increased expression of vSMC markers alpha smooth muscle actin, calponin, and smooth muscle protein 22-alpha, whereas a decrease in collagen 1 expression was observed, indicating a positive contractile phenotype. …”

Flexible, Suturable, and Leak-free Scaffolds for Vascular Tissue Engineering Using Melt Spinning by Julia Fernández-Pérez (16649098)

“…The scaffolds with a higher angle between fibers showed increased expression of vSMC markers alpha smooth muscle actin, calponin, and smooth muscle protein 22-alpha, whereas a decrease in collagen 1 expression was observed, indicating a positive contractile phenotype. …”

Flexible, Suturable, and Leak-free Scaffolds for Vascular Tissue Engineering Using Melt Spinning by Julia Fernández-Pérez (16649098)

“…The scaffolds with a higher angle between fibers showed increased expression of vSMC markers alpha smooth muscle actin, calponin, and smooth muscle protein 22-alpha, whereas a decrease in collagen 1 expression was observed, indicating a positive contractile phenotype. …”