Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma by Marzena Mazur (4761027)

“…Rational design, guided by X-ray analysis of several inhibitors bound to human chitotriosidase (hCHIT1), led to the identification of compound <b>7f</b> as a highly potent AMCase inhibitor (IC₅₀ values of 14 and 19 nM against human and mouse enzyme, respectively) and selective (>150× against mCHIT1) with very good PK properties. …”

NBQX increased PNNs (<i>WFA</i>), tenascin-R, aggrecan and Neurocan in the medial prefrontal cortex in PTZ-treated rats. by Wen Chen (30046)

Chronic PTZ treatment reduced PNNs (<i>WFA</i>), tenascin-R, aggrecan and Neurocan in the medial prefrontal cortex. by Wen Chen (30046)

Follow up and comparative assessment of IgG, IgA, and neutralizing antibody responses to SARS-CoV-2 between mRNA-vaccinated naïve and unvaccinated naturally infected individuals ov... by Salma, Younes

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Withaferin-A Reduces Type I Collagen Expression In Vitro and Inhibits Development of Myocardial Fibrosis In Vivo by Azariyas A. Challa (143195)

“…In mice, administration of 4 mg/kg WF-A daily for 2 weeks reduced isoproterenol-induced myocardial fibrosis by 50%. …”

Mean (top panel) and percentile rank (bottom panel) regression estimates of brain tissue volume across age in the AD sample (n=219). by David Alexander Dickie (499804)

“…<p>The slopes of these lines represent the beta coefficients in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0084093#pone-0084093-t005" target="_blank">table 5</a>. The mean-based model expects all percentile ranks to change at the same rate, i.e. be parallel. …”

Follow up and comparative assessment of IgG, IgA, and neutralizing antibody responses to SARS-CoV-2 between mRNA-vaccinated naïve and unvaccinated naturally infected individuals ov... by Salma, Younes

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h-S100A7-mediated promotion of α-secretase activity and sAPPα secretion and decreased amyloid-beta_1–42 level are prevented by p42/44MAPK and PKC signal-transduction inhi... by Weiping Qin (585156)

Density plot with counts, representing birth dates estimated for calves sampled with their mothers during January 2019 and February 2018. by Michelle Gelippi (9580022)

Protein and mRNA expression of Glo-I in pHEP, pHSC and pLSEC in controls, early and advanced cirrhosis. by Marcus Hollenbach (376231)

Annexin A2 Is a Natural Extrahepatic Inhibitor of the PCSK9-Induced LDL Receptor Degradation by Nabil G. Seidah (148050)

“…Western blotting and immunohistochemistry of <em>AnxA2^−/−</em> tissues revealed that the LDLR was decreased by ∼50% in extrahepatic tissues, such as adrenals and colon. …”

S2 File - by Yosuke Kameno (342665)

“…This initial increase and subsequent decrease in K6 and FCV-19S were more prominent in individuals with high trait anxiety (K6: B = 1.55, 95% CI = 1.18 to 1.91; FCV-19S: B = 4.27, 95% CI = 2.50 to 6.04) and in occupations other than physicians or nurses. …”

S1 File - by Yosuke Kameno (342665)

“…This initial increase and subsequent decrease in K6 and FCV-19S were more prominent in individuals with high trait anxiety (K6: B = 1.55, 95% CI = 1.18 to 1.91; FCV-19S: B = 4.27, 95% CI = 2.50 to 6.04) and in occupations other than physicians or nurses. …”

Histological analyses performed using KB, CaBP, and SMI-32 staining in sections of the hippocampus. by Shigeyoshi Saito (208866)

DAT and NAT activity and the effects of MPP(+) on mitochondrial activity in SH-SY5Y cells. by Joanna A. Korecka (415952)

“…Mitochondrial intensity is significantly increased in RA treated SH-SY5Y cells treated with 0.01 mM MPP(+) up to 0.05 mM, and significantly decreased in cells treated with 0.1 mM, 0.05 mM and 1 mM MPP(+). …”

Effect of SILD on STZ-diabetic kidney: modulation of macrophage infiltration. by Mary Anna Venneri (737094)

Effect of freeze-thaw cycling on grain size of biochar - Fig 10 by Zuolin Liu (633898)

Quantitative determination of loss of MMP in SH-SY5Y cells in response to Grx1 knockdown. by Uzma Saeed (49670)

“…<p>Grx1 was downregulated in SH-SY5Y cells using shRNA. Cells were treated with vehicle after transfecting them with empty vector, or with vehicle, α-lipoic acid (100 µM) or cyclosporine A (10 µM), 6 hr post transfection with shRNA to Grx1 and MMP was measured using TMRM as the indicator dye. …”

Effect of freeze-thaw cycling on grain size of biochar - Fig 6 by Zuolin Liu (633898)

Supplementary Material for: Association of Four Genetic Loci with Uric Acid Levels and Reduced Renal Function: The J-SHIPP Suita Study by Tabara Y. (4123405)

“…<i>Results:</i> Serum UA levels were significantly different between the SLC22A12 rs11231825 (CC/CT/TT: 4.5 ± 1.6, 5.0 ± 1.4, 5.3 ± 1.4 mg/dl; p = 7.6 × 10^–20), SLC2A9 rs1014290 (TT/TG/GG: 4.9 ± 1.4, 5.1 ± 1.4, 5.3 ± 1.4 mg/dl; p = 3.1 × 10^–11) and ABCG2 rs2231142 (TT/TG/GG: 5.3 ± 1.5, 5.2 ± 1.4, 5.1 ± 1.4 mg/dl; p = 2.0 × 10^–5) genotypes. …”