Pharmacological Characterization of Low-to-Moderate Affinity Opioid Receptor Agonists and Brain Imaging with ¹⁸F‑Labeled Derivatives in Rats by Julian Ott (9249432)

“…Observed BP_ND was low, although treatment with naloxone leads to a marked decrease in specific binding, confirming the discovery of a new template for ¹⁸F-labeled OR-agonist PET ligands.…”

Effects of 20 mg·kg⁻¹ salidroside on apoptosis in contusion-injured mice. by Szu-Fu Chen (306048)

“…Bar graph of densitometric analysis of bands showing a significant decrease of (<b>D</b>) cleaved caspase-3 (<b>E</b>) cytosolic CytC and (<b>F</b>) cytosolic Smac/DIABLO protein levels in the ipsilateral hemisphere of SALD-20 treated mice at 1 and 3 days post-injury, compared with vehicle-treated mice. …”

Soluble klotho blocks DAG stimulation of exocytotic insertion of pre-docked TRPC6 vesicles. by Jian Xie (629484)

“…<p>(A, B) Tetanus toxin (TTX) acts on synaptobrevin (“Sb2” for synaptobrevin-2) to decrease surface expression of TRPC6 channels. …”

The homogenization procedure has high impact on the integrity of Abeta plaques with the consequent solubilization and redistribution of Abeta in different fractions. by Sebastian Jimenez (671350)

“…This increment was paralleled by a decrease on the Abeta content from 2% SDS or 4% SDS/8M urea extracted samples (right panel). …”

Clodronate liposomes deplete macrophage numbers. by Valeria De La Rosa-Reyes (6658613)

“…<p>(A, B) Immunohistochemical staining of macrophages with anti-CD68 antibody in the optic nerve at 1 week after axotomy and treatment with (A) DiI-labeled liposomes and PBS (PLipo) or (B) with DiI-labeled clodronate liposomes (Clod Lipo). …”

Palmitate induces PGC−1α promoter methylation in human mutant α−synuclein transgenic mice (DMSYN). by Xiaomin Su (784467)

“…<p>Infusion pumps were implanted with a cannula aiming into the right lateral ventricle. 100uL of solution (PBS, 0.5 uM Pal or 1 uM Pal) were consistently delivered to the brain at a flow rate of 0.25uL/h for 14 days. …”

Data Sheet 2_RvD2 mitigates TNFɑ-Induced mitochondrial reactive oxygen species through NRF2 signaling in placental trophoblasts.pdf by Taija Hahka (20983223)

“…</p>Methods<p>We investigated RvD2’s potential protective mechanisms against TNFα‐induced oxidative stress in trophoblasts by pretreating JEG cells with 100 nM RvD2, followed by exposure to 50 or 100 ng/mL TNFα.…”

Data Sheet 1_RvD2 mitigates TNFɑ-Induced mitochondrial reactive oxygen species through NRF2 signaling in placental trophoblasts.pdf by Taija Hahka (20983223)

“…</p>Methods<p>We investigated RvD2’s potential protective mechanisms against TNFα‐induced oxidative stress in trophoblasts by pretreating JEG cells with 100 nM RvD2, followed by exposure to 50 or 100 ng/mL TNFα.…”

SPEED-ACCURACY TRADE-OFF PARADIGM IN COOPERATIVE TRANSPORT OF ANTS by N FC (19866297)

“…To evaluate this hypothesis, we used ants and artificially generated interspecific competition scenarios by applying formic acid—a defensive alarm pheromone—in various volumes simulating attacks from 10, 100, 500, and 1000 ants, along with a control using distilled water. …”

Characterization of phenotypically unique accessions. by Maria Stefania Przybylska (22756354)

“…<p><b>a)</b> Map of the geographic origin of phenotypically unique accessions, showing those from Sweden (orange) and from Spain (purple). …”

DataSheet_1_Landscape of Peripheral Blood Mononuclear Cells and Soluble Factors in Severe COVID-19 Patients With Pulmonary Fibrosis Development.docx by Zhuolin Wang (8188842)

“…By dissecting the differentially expressed genes, we found an overall downregulation of IFN-responsive genes (STAT1, IRF7, ISG15, ISG20, IFIs, and IFITMs) and S100s alarmins (S100A8, S100A9, S100A12, etc.) in all T-cell clusters, and cytotoxicity-related genes (GZMB, PRF1, and GNLY) in CTLs and γδ T cells in the FI^hi cohort, compared with FI^lo subjects. …”

Data_Sheet_1_Study on the Relationship Between Orthostatic Hypotension and Heart Rate Variability, Pulse Wave Velocity Index, and Frailty Index in the Elderly: A Retrospective Obse... by Lun Li (155358)

“…Analysis software was used to record the subject's standard deviation of the cardiac cycle (SDNN), the standard deviation of the 5-min average cardiac cycle (SDANN), the square root of the average square sum of consecutive n-interval differences (rMSSD), the percentage of the number of adjacent cardiac interval differences >50 ms (pNN50), low frequency (LF), high frequency (HF), very low frequency (VLF), and low frequency/high frequency ratio (LF/HF). …”

Data Sheet 1_Global, regional, and national burden of cardiovascular disease due to dietary risks, 1990–2021.zip by Yunfeng Yu (16389969)

“…In 2021, 5,833,851 deaths and 134,179,728 DALYs from CVD-DR were reported, with an ASMR of 69.81 per 100,000 population and an ASDR of 1,563.86 per 100,000 population. …”

VCC monomer and pre-formed oligomer induce pro-inflammatory responses in the BMDCs. by Shraddha Gandhi (21001590)

“…<p>(A) Dose-dependent increase in cytotoxicity in BMDCs upon treatment with VCC monomer (left panel), and pre-formed VCC oligomer generated in the liposomes (right panel). …”

Temporal Trend in Young-Onset Type 2 Diabetes - the Macrovascular and Mortality Risk: Study of UK Primary Care Electronic Medical Records by Digsu N. Koye (8881108)

“…The incidence rates of ASCVD and ACM declined in people aged ≥50 years, but did not decrease in people <50 years. Compared to people aged ≥50 years, those aged 18-39 years at diagnosis had higher obesity (71% obese), higher HbA1c (8.6%), 71% had high LDL-C, while only 18% were on cardio-protective therapy. …”

DataSheet1_Dynamic model assuming mutually inhibitory biomarkers of frailty suggests bistability with contrasting mobility phenotypes.docx by Nathan Schaumburger (15407399)

“…Here we consider a potential role for bistability in the existence of specific frailty states or phenotypes as part of disablement pathways. …”

<i>Operando</i> Particle-Scale Characterization of Silicon Anode Degradation during Cycling by Ultrahigh-Resolution X‑ray Microscopy and Computed Tomography by Paul Choi (1762975)

“…To capture the transformations of such a large number of Si during cycling, we introduce a standard deviation analysis of the <i>operando</i> transmission X-ray radiograph sequences. …”

<i>Operando</i> Particle-Scale Characterization of Silicon Anode Degradation during Cycling by Ultrahigh-Resolution X‑ray Microscopy and Computed Tomography by Paul Choi (1762975)

“…To capture the transformations of such a large number of Si during cycling, we introduce a standard deviation analysis of the <i>operando</i> transmission X-ray radiograph sequences. …”

<i>Operando</i> Particle-Scale Characterization of Silicon Anode Degradation during Cycling by Ultrahigh-Resolution X‑ray Microscopy and Computed Tomography by Paul Choi (1762975)

“…To capture the transformations of such a large number of Si during cycling, we introduce a standard deviation analysis of the <i>operando</i> transmission X-ray radiograph sequences. …”

Down-regulation of PCNA increases the number of oocytes by alleviating the apoptosis of oocytes in fetal mouse ovaries. by Bo Xu (233514)

“…Bar: 100 µm. (<b>B</b>) The number of oocytes decreased gradually with time of transfection in PCNA RNAi or control ovaries, while the decrease in control ovaries was more dramatic than in PCNA RNAi ovaries. …”