Brain regions (ROIs) showing significantly increased ReHo in StD group (decreased ReHo in NC) (two sample <i>t</i>-test, thresholded at <i>p</i><0.005 with an extent threshold 5 co... by Zhenling Ma (290924)

Nrf2 is necessary for optimal PMN migration toward CXCL12 and CXCL2 without regulating receptors expression. by Doumet Georges Helou (7255823)

Semi-log plot of the total number of medals obtained by countries at Beijing (BJG) and London (LDN) recent Summer Olympic Games, as ranked according to their decreasing “order of i... by Marcel Ausloos (748325)

Semi-log plot of the number of Gold medals obtained by countries at Beijing (BJG) and London (LDN) recent Summer Olympic Games, as ranked according to their decreasing “order of im... by Marcel Ausloos (748325)

Image_3_IGF-1R Inhibitor Ameliorates Neuroinflammation in an Alzheimer’s Disease Transgenic Mouse Model.TIF by Mona Sohrabi (9082586)

Image_1_IGF-1R Inhibitor Ameliorates Neuroinflammation in an Alzheimer’s Disease Transgenic Mouse Model.TIF by Mona Sohrabi (9082586)

Image_2_IGF-1R Inhibitor Ameliorates Neuroinflammation in an Alzheimer’s Disease Transgenic Mouse Model.TIF by Mona Sohrabi (9082586)

Fatal autoimmune disorder in mice with T_reg cell–specific disruption of <i>miR-142</i>. by Wei-Le Wang (133402)

S2 Table - by Penny A. Rudd (10298691)

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…The corresponding epigenetic functional cellular responses are observed: histone-3 acetylation, DNA hypomethylation, and decreased histone-3 methylation at lysine-9. These chemical probes, multitarget epigenetic inhibitors, were validated against the multiple myeloma cell line MM1.S, demonstrating promising <i>in vitro</i> activity of <b>12a</b> (CM-444) with GI₅₀ of 32 nM, an adequate therapeutic window (>1 log unit), and a suitable pharmacokinetic profile. …”

Mst1 knockout skewed macrophage polarization toward a proinflammatory and profibrotic phenotype with concomitant down-regulation of CD36. by Jianyang Li (461703)

Secondary attack rates among 1407 close contacts based on case-patient^a characteristics, their own characteristics, and exposure setting. by Joseph Walker (4341838)

Blockade of IFN<i>γ</i> production rescues the T_reg cell homeostatic defect and alleviates systemic autoimmunity in <i>Foxp3</i>^<i>Cre</i><i>miR-142</i><sup><... by Wei-Le Wang (133402)

HCV elicits differential expression of circRNAs. by Tzu-Chun Chen (787255)

Mendelian randomization results with COVID-19. by Alish B. Palmos (5857379)

Schematic diagram of STTFP model. by Guozhu Sui (21672798)

Expression of CRYAB in normal and tumor tissue samples across different cancer types. by Rasool Saghaleyni (10526301)

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…The corresponding epigenetic functional cellular responses are observed: histone-3 acetylation, DNA hypomethylation, and decreased histone-3 methylation at lysine-9. These chemical probes, multitarget epigenetic inhibitors, were validated against the multiple myeloma cell line MM1.S, demonstrating promising <i>in vitro</i> activity of <b>12a</b> (CM-444) with GI₅₀ of 32 nM, an adequate therapeutic window (>1 log unit), and a suitable pharmacokinetic profile. …”

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…The corresponding epigenetic functional cellular responses are observed: histone-3 acetylation, DNA hypomethylation, and decreased histone-3 methylation at lysine-9. These chemical probes, multitarget epigenetic inhibitors, were validated against the multiple myeloma cell line MM1.S, demonstrating promising <i>in vitro</i> activity of <b>12a</b> (CM-444) with GI₅₀ of 32 nM, an adequate therapeutic window (>1 log unit), and a suitable pharmacokinetic profile. …”

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…The corresponding epigenetic functional cellular responses are observed: histone-3 acetylation, DNA hypomethylation, and decreased histone-3 methylation at lysine-9. These chemical probes, multitarget epigenetic inhibitors, were validated against the multiple myeloma cell line MM1.S, demonstrating promising <i>in vitro</i> activity of <b>12a</b> (CM-444) with GI₅₀ of 32 nM, an adequate therapeutic window (>1 log unit), and a suitable pharmacokinetic profile. …”