Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…The corresponding epigenetic functional cellular responses are observed: histone-3 acetylation, DNA hypomethylation, and decreased histone-3 methylation at lysine-9. These chemical probes, multitarget epigenetic inhibitors, were validated against the multiple myeloma cell line MM1.S, demonstrating promising <i>in vitro</i> activity of <b>12a</b> (CM-444) with GI₅₀ of 32 nM, an adequate therapeutic window (>1 log unit), and a suitable pharmacokinetic profile. …”

miR-223 Is a Coordinator of Breast Cancer Progression as Revealed by Bioinformatics Predictions by Eva Maria Pinatel (506111)

DNMT1 reduces cisplatin sensitivity partially through downregulating FOXO3a in ovarian cancer cells by Chong Guo (5819105)

“…Knocking down of DNMT1 could decrease the IC₅₀ of cisplatin. Treatment with cisplatin may reduce FOXO3a expression in OC cells. …”

Density plots (A) and restricted cubic splines (B) of the associations of 1-year change (%) in weight and waist circumference after diabetes diagnosis with incident remission of ty... by Hongjiang Wu (449543)

Image_1_Interleukin-17A Mediates Hippocampal Damage and Aberrant Neurogenesis Contributing to Epilepsy-Associated Anxiety.TIF by In-Young Choi (3025167)

Image_2_Interleukin-17A Mediates Hippocampal Damage and Aberrant Neurogenesis Contributing to Epilepsy-Associated Anxiety.TIF by In-Young Choi (3025167)

More focal female offspring produced on dishes where the prior occupant was a related female, while more conspecific offspring were produced on dishes where the female was unrelate... by Emily Rakosy (20939774)

Suppression by extracellular QRNA from TNP Ts Sup free of exosomes, or miR-150 alone, associating with B-cell derived Ag-specific exosomes from the assayed CS-effector cell mixture... by Krzysztof Bryniarski (731989)

“…</b></u> Similarly, two day immune B-1 B cell-derived exosomes, supplemented with decreasing doses of miR-150 alone, mediated suppression of TNP-CS-effector cell adoptive transfer (Groups E-G), down to a dose of 750pg per eventual recipient, which is 50 femtomoles per eventual recipient (Group G). …”

Localization of auditory activation. by Ana Todorovic (709034)

Egg mass output for uninfected snails in treatment groups 0.38 ppt, 1.9 ppt, 3.8 ppt, and 5.7 ppt. by Ao Yu (1348512)

Variable-precision model of VWM. by Yi-Jie Zhao (11663148)

Portfolios with different number of securities involved in E(r) – risk system. by Mihály Ormos (697939)

Immunohistochemical staining showing the expression of phosphorylated p38 in the mouse renal tubulointerstitial area after UUO and administration of p38 MAPK inhibitor. by Jeonghwan Lee (286889)

“…<p>Scale bar = 50 μm (original magnification x300). (A) Sham-operated group. …”

The proliferation and angiogenesis of the fat pad. by Yunjun Liao (728631)

“…<p>A: The number of Ki67+ cells (white arrow) was increased during expension (day 0 left, day 14 right). …”

Expression of FASN in human glioblastoma cells and GSC lines. by Yuki Yasumoto (685821)

DataSheet1_Assessing susceptibility for polycyclic aromatic hydrocarbon toxicity in an in vitro 3D respiratory model for asthma.PDF by Reese M. Valdez (18408114)

“…Cells with the IL-13 phenotype treated with BAP result in significantly (p < 0.05) decreased barrier integrity, less than 50% compared to normal cells. …”

Relationship between costs and service scale. by Nerissa Nance (4404940)

“…By increasing the annual number of services by 100 percent, the unit cost decreases by 50 percent for HIVE, 40 percent for HCT, and 10 percent for STI. …”

Correlation between fat fraction and M2BPGi. by Eun-Hee Nah (11751972)

“…Fatty liver at or above the moderate grade according to US was decreased at month 12 relative to baseline (67.6% vs 50.9%) (<i>P</i> = 0.002). …”

CONSORT flow diagram. by Eun-Hee Nah (11751972)

“…Fatty liver at or above the moderate grade according to US was decreased at month 12 relative to baseline (67.6% vs 50.9%) (<i>P</i> = 0.002). …”

Fig 4 - by Nerissa Nance (4404940)