Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Structure-function correlation of the central retina in a patient with X-linked retinoschisis (upper panels) and a patient with Usher syndrome 2A (lower panels). by Peter Charbel Issa (241475)

“…Only the most distinct alterations result in a relative scotoma (10 dB decreased light intensity compared to the brightest stimulus). …”

Lack of HP1a or POF shifts the enrichment pattern of RNA pol II on chromosome 4. by Nicole C. Riddle (134424)

“…In both HP1a and POF mutants, the RNA pol II enrichment decreases significantly only in the gene body. …”

Zinc exposure attenuates NR2A clusters and currents. by Jia Zhu (135506)

“…Both the number and mean intensity of NR2A clusters significantly decreased after zinc treatment. …”

Pharmacological inhibition and genetic manipulation of Mif and its cognate receptor suppresses apoptosis-induced proliferation. by Safia A. Essien (20108379)

Antibiotic Resistome Changes Associated with Different Types of Corrosion Inhibitors When Chlorine is Used as a Disinfectant by Lee K. Kimbell (21520910)

Intravenous treatment of naïve wild-type mice with PrP LSPCs decreased PrP^C mRNA and cell surface PrP^C protein at various time points. by Heather Bender (363996)

Fig 7 - by B. Ulfhake (6293984)

Fig 8 - by B. Ulfhake (6293984)

Fig 6 - by B. Ulfhake (6293984)

Fig 12 - by B. Ulfhake (6293984)

Bmi1 Essentially Mediates Podocalyxin-Enhanced Cisplatin Chemoresistance in Oral Tongue Squamous Cell Carcinoma by Yueying Zhou (450705)

“…On the other hand, knockdown of PODXL significantly decreased the Bmi1 expression level and cisplatin IC50 and increased cisplatin-induced cell apoptosis, which was completely reversed by overexpression of Bmi1. …”

Fig 18 - by B. Ulfhake (6293984)

Fig 11 - by B. Ulfhake (6293984)

Circadian rhythmicity of in-cage activity of male (upper panel) and female (lower panel) mice at the four sites. by B. Ulfhake (6293984)

Minute-based frontality and latrine positions day-by-day across cage-change cycles. by B. Ulfhake (6293984)

Poly (I:C) intervention reduced myofibroblast activation and collagen fibrosis deposition in <i>C</i>. by Yuru Wang (846969)

Data_Sheet_1_Flagellin C decreases the expression of the Gossypium hirsutum cation/proton exchanger 3 gene to promote calcium ion, hydrogen peroxide, and nitric oxide and synergist... by Heng Zhou (287510)