Temporal Trend in Young-Onset Type 2 Diabetes - the Macrovascular and Mortality Risk: Study of UK Primary Care Electronic Medical Records by Digsu N. Koye (8881108)

“…The incidence rates of ASCVD and ACM declined in people aged ≥50 years, but did not decrease in people <50 years. Compared to people aged ≥50 years, those aged 18-39 years at diagnosis had higher obesity (71% obese), higher HbA1c (8.6%), 71% had high LDL-C, while only 18% were on cardio-protective therapy. …”

Quantitative Analysis of the Extracellular Response Kinase 1 and 2 (ERK1/2), Calcium-Calmodulin Kinase II (CAMKII), Fragile X Protein (FMRP), and the Nicotinic Acetylcholine Recept... by Robert K. Naviaux (256148)

“…<p>(A) ERK1 (MAPK3) and ERK2 (MAPK1) phosphorylation was decreased by over 90% by gestational poly(IC) exposure and normalized by suramin treatment (Sal-Sal = 100+/−5%; Sal-Sur = 6.2+/−0.8%; PIC-Sal = 9.9+/−2.6%; PIC-Sur = 84+/−2.3%; one-way ANOVA F(3,12) = 241; p<0.0001; n = 4–5 males per group; age = 16 weeks). …”

γδ T cells have similar TCR threshold but enhanced ERK1/2 phosphorylation comparing to αβ T cells. by Hsin-Yuan Cheng (414160)

“…Results were averaged from 5 mice, and shown in mean ± SEM. Lower: Log scaling of αCD3 concentration against % of maximum response was used to calculate EC₅₀. …”

Neurobehavioral performance at baseline and during chronic partial sleep deprivation for the <i>PER3</i> groups. by Namni Goel (336535)

“…<p>Mean (±SEM) (A) PVT lapses (>500 ms reaction times) per trial, (B) total number correct per trial on the Digit Symbol Substitution Task (DSST) and (C) Digit Span (DS) task, and scores per trial on the (D) Karolinska Sleepiness (KSS) and (E) “Fresh-Tired” Visual Analog Scale (VAS) at baseline (B) and each partial sleep deprivation/restriction night (SR1-SR5) for <i>PER3^4/4 (open circles)</i>, <i>PER3^4/5 (gray triangles)</i> and <i>PER3^5/5 (closed circles)</i> subjects. …”

Antioxidant activity of BT and plasma. by Wei-Yi Wu (1785187)

“…H₂O₂ scavenging activity was indicated by CL counts in several kinds of water. CL counts were decreased by 0.5 BT, 1 BT, 2 BT and 5 BT (n = 3). RO, reverse osmosis. …”

hGAG suppresses p38 and ERK signaling to inhibit TF expression in B16F10 tumor cells. by Yang Zhao (39052)

“…PMA-induced expression of TF in B16F10 tumor cells was significantly decreased by hGAG at >0.5 µM. All data are represented as mean ± S.E. from 3–5 independent experiments. …”

Population sorting II. by Xavier Manière (230820)

“…<p>(A) We numerically computed the histograms of the distance traveled by a fictitious population of 1000 worms assuming a Gaussian velocity distribution for each worm with an average parallel velocity given by v₀(1+gnoise(µ)) and a standard deviation of 50 µm/s. …”

Tobacco control in the Eastern Mediterranean region: implementation progress and persisting challenges by Abu-Rmeileh, Niveen M E

“…Tobacco use is the leading cause of preventable mortality worldwide, projected to claim 1 billion lives in the twenty-first century.1 Tobacco prevalence rates are expected to decrease across all the WHO regions by 2025 as a result of tobacco control efforts. …”
Get full text
Get full text

Concomitant experimental coinfection by Plasmodium berghei NK65-NY and Ascaris suum downregulates the Ascaris-specific immune response and potentiates Ascaris-associated lung patho... by Flaviane Vieira-Santos (8357704)

“…The concentrations of interleukin (IL)-1β, IL-12/IL-23p40, IL-6, IL-4, IL-33, IL-13, IL-5, IL-10, IL-17A, IFN-γ, TNF-α and TGF-β were assayed by sandwich ELISA. …”

Data_Sheet_4_Omeprazole Increases the Efficacy of Acyclovir Against Herpes Simplex Virus Type 1 and 2.PDF by Martin Michaelis (23843)

“…Omeprazole 80 μg/mL caused a 10.8-fold (Vero cells) and 47.7-fold (HaCaT cells) decrease of the acyclovir concentrations that reduced HSV-1-induced CPE formation by 50% (IC₅₀). …”

Effect of De-intensifying Diabetes Medications on Negative Events in Older Veteran Nursing Home Residents by Joshua D. Niznik (12480320)

“…Diabetes treatment de-intensification (dose decrease or discontinuation of a non-insulin agent or stopping insulin sustained ≥7 days) was identified within 30 days following HbA1c measurement. …”

Untargeted Urinary Proteomics Uncovers Nephroprotective and Systemic Adaptations after Obesity Surgery-Induced Weight Loss by Pedro R. Pereira (6016460)

“…A decrease in inflammation protein markers (α-1-acid glycoproteins), alongside an increase in proteins associated with immune modulation and oxidative stress protection (dipeptidase 1, heat shock cognate 71 kDa protein) were observed. …”

Data_Sheet_2_Omeprazole Increases the Efficacy of Acyclovir Against Herpes Simplex Virus Type 1 and 2.PDF by Martin Michaelis (23843)

“…Omeprazole 80 μg/mL caused a 10.8-fold (Vero cells) and 47.7-fold (HaCaT cells) decrease of the acyclovir concentrations that reduced HSV-1-induced CPE formation by 50% (IC₅₀). …”

Data_Sheet_1_Omeprazole Increases the Efficacy of Acyclovir Against Herpes Simplex Virus Type 1 and 2.PDF by Martin Michaelis (23843)

“…Omeprazole 80 μg/mL caused a 10.8-fold (Vero cells) and 47.7-fold (HaCaT cells) decrease of the acyclovir concentrations that reduced HSV-1-induced CPE formation by 50% (IC₅₀). …”

Data_Sheet_2_Isolation and Characterization of Nitrate-Reducing Bacteria as Potential Probiotics for Oral and Systemic Health.xlsx by Bob T. Rosier (2601973)

“…When adding nitrate (prebiotic treatment) or isolates in combination with nitrate (symbiotic treatment), a smaller decrease in pH derived from sugar metabolism was observed (p < 0.05), which for some symbiotic combinations appeared to be due to lactate consumption. …”

Incubation of IN in active cytosol (CC) demonstrates movement of membrane lipids from ONM to INM and changes in phosphatidylinositides profile by Amalia Slomiany (21178)

“…</p> During 60 min incubation with CC, the radiolabeled lipids decrease in the ONM and INM (A and B, respectively). …”

Dynamic linear modeling of monthly electricity demand in Japan: Time variation of electricity conservation effect by Keita Honjo (780244)

“…It is reported that the domestic electricity demand had a structural decrease because of the electricity conservation effect (ECE). …”

Identification of aa 100-200 as the transcriptional activation domain for WC-1. by Bin Wang (30851)

“…Both WT WC-1 and mutants were C-terminally tagged with V5. Δ101-200 showed a significant decrease of <i>frq</i> expression and further deletion of aa 1-200 or 1-300 further dimished <i>frq</i> expression. …”

Heat map grid summarizing the effects of LPS, (+)-JQ and (-)-JQ1 on histone 3 acetylation at the promoters of <i>IL6</i>, <i>CXCL8/IL8</i>, <i>TNF</i>, <i>IL10</i> and <i>IDO1</i>. by Sandeep Ajgaonkar (14774336)

“…The significance threshold is 5% FDR (Q<0.05), highlighted in bold. The orange color indicates a significant increase, the blue color indicates a significant decrease in the acH3 ChIP signal regarding the contrasts shown. …”

Data_Sheet_1_Isolation and Characterization of Nitrate-Reducing Bacteria as Potential Probiotics for Oral and Systemic Health.docx by Bob T. Rosier (2601973)

“…When adding nitrate (prebiotic treatment) or isolates in combination with nitrate (symbiotic treatment), a smaller decrease in pH derived from sugar metabolism was observed (p < 0.05), which for some symbiotic combinations appeared to be due to lactate consumption. …”