PINK1 expression alters mitochondrial function and cellular viability. by Anna Sandebring (263540)

“…The PINK1 in these cells is V5-tagged at the C-terminus, the precursor (arrow) and mature (closed arrowhead) forms of PINK1 are visible. …”

Dynamic analysis of EC movements within Tg(<i>tie1</i>:H2B-eYFP) embryos. by Yuki Sato (243074)

“…A representative time lapse video (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0012674#pone.0012674.s004" target="_blank">Video S4</a>) was processed as follows: cropped time frames (5 through 67) corresponding to HH stages 9 to 11 and restricted region of interest to trunk level (posterior to somite 7, frame size is 500 mm ×1300 mm), and reduced noise using a median filter (3×3×3). …”

Age associated arrhythmicity is dependent on <i>ena</i> function. by Carolina Rezával (270700)

“…(C) Representative actograms of young (3d) and aged (21d) flies carrying one or two copies of <i>ena^rev</i>, along with the transheterozygotes <i>ena^rev</i>/<i>ena^GC5</i>. Both homozygous <i>ena^rev</i> and <i>ena^rev</i>/<i>ena^GC5</i> exhibit a decline on rhythm strength. …”

Nerve conduction study and nerve ultrasound as biomarkers for steroid dependence in chronic inflammatory demyelinating polyneuropathy by Jingwen Niu (538210)

Reliance of AML on MCL1 confers sensitivity to fadraciclib. by Sheelagh Frame (578026)

“…<p><b>A.</b> Graph depicting IC_50/70//90, values determined by resazurin reduction cytotoxicity assay after a 6 h pulse treatment with fadraciclib (CYC065) followed by 66h of release. …”

Chloroquine (CQ) treatment blocks autophagosome–lysosome fusion and induces myopathy in the larva. by Jonathan Zirin (483506)

“…(M) Quantification of autophagy changes due to <i>Atg</i> gene knockdown in <i>Dmef2</i>–<i>Gal4</i>, <i>UAS</i>–<i>GFP</i>–<i>Atg8</i> larvae starved on low-nutrient food +2.5 mg/ml CQ for 6 h. Each of the 10 <i>UAS</i>–<i>Atg</i> RNAi transgenes tested caused a highly significant decrease (<i>p</i><.01) in the total area of GFP–Atg8 vesicles. …”

Individual recording analysis. by Sonya Marshall-Gradisnik (3525122)

“…PregS amplitude = (B)–(A) and Ononetin amplitude = (C)–(D). PregS was effective when presented with an increase at +100 mV current and Ononetin was effective when there is a decrease at +100 mV current. …”

Amastigote susceptibility results of the <i>in vivo</i> resistance selection procedure to PMM-MIL combination therapy. by Sarah Hendrickx (321143)

“…Exposure to PMM alone (ITMAP263 PMM) revealed a significant susceptibility decrease (indicated in bold)[<a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0005620#pntd.0005620.ref014" target="_blank">14</a>]. …”

Numerical analysis of the effective stiffness of elastomeric bearing pads under precast beams for the limit load of lateral instability by L. C. REIS (8652054)

Do sit-to-stand performance changes during gait acquisition? by Alana Maria Ferreira Guimarães Bastos (12838317)

“…At the gait acquisition period we found a significant decrease in the final trunk flexion angle and an increase in amplitude of the trunk flexion. …”

Heme dissociation kinetics for wild-type and mutant IsdX1. by MarCia T. Ekworomadu (178999)

“…Proteins were re-constituted with heme, excess heme removed by gel filtration chromatography, and holo proteins (1 µM) mixed with H64Y/V68F apo-Mb (26 µM) at 25°C in PBS, pH 7.4. Time courses for hemin dissociation the IsdX1 variants were determined by measuring the difference between in the increase in absorbance at 419 nm (peak for holo H64Y/V68F holo-Mb) and the decrease in absorbance at 380 nm (strong absorbance by holo-IsdX1).…”

QTL mapping of male sterility and transmission pattern in progeny of Satsuma mandarin by Shingo Goto (739660)

“…The QTL for APF (<i>MS-F1</i>) was detected on linkage group 6 with a significant LOD score (5.71) and 63.6% of variance explained. …”

Table_1_Impacts of glacial and sea-ice meltwater, primary production, and ocean CO2 uptake on ocean acidification state of waters by the 79 North Glacier and northeast Greenland sh... by Agneta Fransson (471604)

“…This was most pronounced near the 79NG front in 2012, where surface stratification was most pronounced coinciding with large glacial meltwater fractions. Freshening decreased Ω_Ar by 0.4 at the 79NG front was compensated by biological CO₂ drawdown by ~0.5. …”

Regulation of GGA expression alters APP processing and sAPP secretion. by Bjoern von Einem (751380)

“…Additionally, deletion of GGA2-VHS led to an even stronger decrease in sAPP levels. Experiments were carried out in triplicate; shown are the results of n = 5 independent experiments. …”

Features of assembled parent communities. by Pablo Lechón-Alonso (11663433)

“…<b>B</b>: Change in proportion of species m-preferences consumers before and after assembly (Δ<i>m</i>_<i>r</i>, <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1009584#pcbi.1009584.e017" target="_blank">Eq 5</a>, y axis) as a function of the number of metabolic preferences (x axis), for three different values of <i>k</i>_<i>c</i> (legend in panel C), calculated after each simulation, and averaged across simulations. …”

Effect of Flow Conditions on the Dynamics of Chemical Demulsification in Highly Viscous Emulsion Flow by Samuel Vitor Saraiva (17984521)

High dose wIFN-α significantly induced intrahepatic expression of T cell, NK cell and IFN-γ response genes. by Simon P. Fletcher (793613)

“…</p><p>^aFold-change ratio values relative to time-matched placebo animals (n = 5–12) are displayed, with underlining denoting statistical significance (FDR<0.05). …”

Supplementary Material for: Impact of Medium Cut-Off Dialyzers on Patient-Reported Outcomes: COREXH Registry by Alarcon J.C. (9627059)

“…No significant differences in the number of symptoms (DSI, <i>p =</i> 0.1) were observed, although their severity decreased (<i>p</i> = 0.009). <b><i>Conclusions:</i></b> In conventional HD patients, the expanded clearance of large middle molecules with MCO-HD membranes was associated with higher health-related quality of life scores and a decrease in the prevalence of RLS.…”

Table_1_The Influence of Social Isolation on Social Orientation, Sociability, Social Novelty Preference, and Hippocampal Parvalbumin-Expressing Interneurons in Peripubertal Rats –... by Milica Potrebić (12494344)

“…The main findings are the following: (1) in GH rats, the preference for social space is not evident regardless of animals’ age, while sociability becomes apparent in mid-adolescence strictly through consummatory behavior, along with complete SNP (appetitive, consummatory); (2) SH promotes staying in a social chamber/space regardless of animals’ age and produces an appetitive preference for it only in early-adolescent animals; (3) SH promotes sociability (appetitive, consummatory) regardless of the animals’ age and prevents the SNP; (4) the preference for a social odor is displayed in all the groups through consummatory behavior, while appetitive behavior is evident only in SH rats; (5) the response to social odors does not commensurate directly to the response to conspecifics; (6) SH does not influence PVI in the hippocampus, except in the case of early-adolescence when a transient decrease in the dentate gyrus is observed. …”

Image_1_Impacts of glacial and sea-ice meltwater, primary production, and ocean CO2 uptake on ocean acidification state of waters by the 79 North Glacier and northeast Greenland sh... by Agneta Fransson (471604)

“…This was most pronounced near the 79NG front in 2012, where surface stratification was most pronounced coinciding with large glacial meltwater fractions. Freshening decreased Ω_Ar by 0.4 at the 79NG front was compensated by biological CO₂ drawdown by ~0.5. …”