Results of phantom eye model. by Makoto Shirasawa (438600)

“…<p>Representative SD-OCT images of phantom eye model (A–C). A, ART = 1; B, ART = 20; C, ART = 100. ART =  number of frames averaged. …”

Sampling design. by Kiwako S. Araki (680112)

“…Vegetation cover data was used as a measure of environmental heterogeneity (a), and the spatial distribution of genets (groups of clonal ramets with shared genotypes) was determined through simple sequence repeat (SSR) analyses (b). …”

Tuning the Attempt Frequency of Protein Folding Dynamics via Transition-State Rigidification: Application to Trp-Cage by Rachel M. Abaskharon (1351644)

“…We find that this strategy not only decreases the folding time of the Trp-cage peptide by more than an order of magnitude (to ∼100 ns at 25 °C) but also exposes parallel folding pathways, allowing us to provide, to the best of our knowledge, the first quantitative assessment of the curvature of the transition-state free-energy surface of a protein.…”

Prevalence and rate of reversion of RT mutations at baseline (BL), 2 months (2mo) and 4 months (4mo) Structured Treatment Interruption (STI) and associated changes in Replication C... by Agnes C. Paquet (231161)

“…Between 2 months and 4 months of STI, the reversion of mutations was also associated with an increase in RC, although of a lesser magnitude since RC was already close to 100% at 2 months (data not shown).…”

Constructions of tryptase lentivirus carrier and tryptase siRNA lentivirus carrier. by Xiuling Zhi (397887)

“…Same fields of vision under an optical microscope(×100). More than 80% cells were infected with lent-GFP at a dose of MOI 10 after 48 h treatment. …”

Knockdown of PTEN in NMECs generates disorganized hyperplastic lesions in humanized NOD/SCID mice. by Hasan Korkaya (159560)

“…Outgrowths with PTEN knockdown showed increased CK5/6 expression (c and j) and decreased CK18 expression (d and k), as well as a lack of ERα expression compared to control cells (e and l). …”

Study Design Subgroup Analyses by Corey Simpson (18475386)

“…</b> The three cohort studies showed a statistically significant decreased association with skin cancer (HR 0.88, 95% CI 0.78-0.99) and high study heterogeneity (<i>I</i>² 79%). …”

The <i>fat-7</i> desaturase is regulated by <i>paqr-2</i> and its suppressors. by Emma Svensk (458231)

“…<p>(<b>A</b>) The <i>paqr-2</i> mutant has decreased expression of <i>fat-7</i>, while strains carrying the <i>paqr-2</i> suppressors <i>nhr-49(et8)</i> or <i>cept-1(et10)</i> show a marked increase in <i>fat-7</i> expression when compared to control worms (wt). …”

IL-12 has opposite effects on IL-2R expression by Tregs vs non-Treg T cells. by Jingxian Zhao (258023)

“…<p>Lymphocytes were prepared from naïve <i>Foxp3^gfp</i> mice and treated with anti-CD3 mAb and IL-12 or IFN-γ for 66 hr. (A, B) CD25 expression was decreased on Tregs and increased on Tconvs and CD8 T cells by IL-12 in a dose-dependent fashion. …”

Predicted changes in species overlap with increasing temperatures. by Mary E. Hunsicker (422709)

“…<p>Predicted increases in predator and prey occurrences (black circles) and probability of species overlap (red circles) with a standardized unit increase in spatially explicit bottom temperatures in the early regime (based on year 1987; A, overlap; C, flounder; E, juvenile pollock) and late regime (based on year 2005; B, overlap; D, flounder; F, juvenile pollock). …”

Thapsigargin versus glucose deprivation and F7 mRNA expression. by Katherine R. Cronin (146594)

“…Expression at 25 mM glucose and without thapsigargin were considered 100% expression for each amplicon; other groups were expressed as a percentage +/− SD relative to this. …”

Time-Response EEG activity of SR9009 during the light phase. by Ariadna Amador (2560231)

“…Mice were dosed with SR9009 at different time points (ZT3, ZT6, and ZT9) on separate days in order to generate a Time-Response Curve. (<b>B</b>) Injections with SR9009 (i.p. 100mg kg^-1) induced wakefulness at ZT6 (p<0.05), but not ZT3 and ZT9, reduced SWS at ZT6 (p<0.05), but not ZT3 and ZT9, and decreased significantly REM sleep at ZT3 (p<0.05), and ZT6 (p<0.05), but not at ZT9. …”

H&E stained histological evaluation of mouse lungs in the control, PQ, PQ + low-dose APN, and PQ + high-dose APN groups on days 3, 7, 14, 21 after PQ injection (×200 magnification)... by Rong Yao (735448)

“…<p>Compared with control group, PQ (10 mg/kg) intoxication showed progressively interstitial edema and inflammatory cell infiltration in the alveolar space and septum from day 3, reaching a peak on day 14. Both low high-dose (100 μg/kg) and high-dose (500 μg/kg) APN groups showed remarkably decreased interstitial edema and inflammatory cell infiltration, in a dose-dependent manner.…”

Table_4_Clonally Focused Public and Private T Cells in Resected Brain Tissue From Surgeries to Treat Children With Intractable Seizures.xlsx by Julia W. Chang (6271082)

“…Conversely, we found that the frequency in the blood of 18 of the top 50 brain clonotypes from a second TSC patient, who was seizure free, had significantly decreased 5 months after surgery indicating that T cell clones found in the brain had contracted in the periphery after removal of the brain area associated with seizure activity and inflammation. …”

Data_Sheet_1_Evaluating longitudinal relationships between parental monitoring and substance use in a multi-year, intensive longitudinal study of 670 adolescent twins.docx by Jordan D. Alexander (15456644)

“…This allowed us to assess how individual-level parental monitoring and substance use trajectories were related and, via the twin design, to quantify genetic and environmental contributions to these relationships. Furthermore, we attempted to devise additional measures of parental monitoring by collecting quasi-continuous GPS locations and calculating a) time spent at home between midnight and 5am and b) time spent at school between 8am-3pm.…”

Table1_Short hydrocarbon stapled ApoC2-mimetic peptides activate lipoprotein lipase and lower plasma triglycerides in mice.docx by Denis Sviridov (4630546)

“…We recently described a dual ApoC2 mimetic/ApoC3 antagonist peptide called D6PV that effectively lowered TG in several mouse models but has limitations in terms of drug development. …”

Data_Sheet_1_Systematic Analysis of Differential H3K27me3 and H3K4me3 Deposition in Callus and Seedling Reveals the Epigenetic Regulatory Mechanisms Involved in Callus Formation in... by Nannan Zhao (4331221)

“…Furthermore, data for DNase I-hypersensitive sites in the corresponding tissues were downloaded from National Center for Biotechnology Information. We analyzed 4,562 callus H3K27me3-decreased genes especially those encoding transcription factors in callus, and found that most of the transcription factors, including AP2-ERREBP, NAC, and HB gene families, were related to growth and development. …”

DataSheet1_Discovery of a New CDK4/6 and PI3K/AKT Multiple Kinase Inhibitor Aminoquinol for the Treatment of Hepatocellular Carcinoma.ZIP by Zhong-Kun Xia (7369511)

“…</p><p>Methods: Using a repurposing and ensemble docking methodology, we screened a library of worldwide approved drugs to identify candidate CDK4/6 inhibitors. …”

Data_Sheet_1_Morphological and physiological response of Chinese tallow (Triadica sebifera) to an extreme cold spell in subtropical, coastal forests of China.pdf by Hongtao Xie (6617459)

“…As age may affect tree morphological and physiological response to stress, we grouped subject trees into three distinct cohorts, namely, seedlings (1–2 years old), young-aged (5–6 years old), and middle-aged (10–12 years old). …”

Data_Sheet_3_Evaluating longitudinal relationships between parental monitoring and substance use in a multi-year, intensive longitudinal study of 670 adolescent twins.pdf by Jordan D. Alexander (15456644)

“…This allowed us to assess how individual-level parental monitoring and substance use trajectories were related and, via the twin design, to quantify genetic and environmental contributions to these relationships. Furthermore, we attempted to devise additional measures of parental monitoring by collecting quasi-continuous GPS locations and calculating a) time spent at home between midnight and 5am and b) time spent at school between 8am-3pm.…”