The Interference of Notch1 target Hes1 affects cell growth, differentiation and invasiveness of glioblastoma stem cells through modulation of multiple oncogenic targets حسب Cenciarelli, Carlo

"…In the last decade Stat3 has gained attention as therapeutic target in cancer but there is not yet any approved Stat3-based glioma therapy. Herein, we report that exposure to a Stat3/5 inhibitor, induced apoptosis either in shHes1-CSC or control cells. …"
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Quantification of the growth suppression of HER2+ breast cancer colonies under the effect of trastuzumab and PD-1/PD-L1 inhibitor. حسب Padmanabhan, Regina

"…Precisely, several questions regarding the right combination of drugs, drug modality, and effective dose recommendations pertaining to the use of ICB-based therapy for HER2+ patients remain unanswered. In this study, we use a mathematical modeling-based approach to quantify the growth inhibition of HER2+ breast cancer (BC) cell colonies (ZR75) when treated with anti-HER2; trastuzumab (TZ) and anti-PD-1/PD-L1 (BMS-202) agents. …"
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Effect of plastic deformation on Corrosion of cadmium in 0.1 m sodium Sulphate solution حسب Kandeil, A. Y. [عبد الرزاق يوسف قنديل]

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Nanotargeted Delivery of Immune Therapeutics in Type 1 Diabetes حسب Jung, Sungwook

"…To address this, a novel and specific nanodelivery platform for T1D that targets high endothelial venules (HEVs) presented in the pancreatic lymph nodes (PLNs) and pancreas is developed. …"
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Enhancement of flocculation and dewaterability of a highly stable activated sludge using a hybrid system of organic coagulants and polyelectrolytes حسب Yousefi S.A.

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The Expression of TBC1 Domain Family, Member 4 (TBC1D4) in Skeletal Muscles of Insulin-Resistant Mice in Response to Sulforaphane حسب Rizk, Nasser M

"…Sulforaphane (SFN) has been suggested as a new potential anti-diabetic compound acting by reducing blood glucose levels through mechanisms not fully understood (1). …"
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Structural evaluation, preliminary in vitro stability and electrochemical behavior of apatite coatings on Ti6Al4V substrates حسب Yaser E. Greish

"…In the current work, a sputtering technique was used to develop a 300 nm-thick bone-like apatite layer onto Ti-6Al-4V. …"
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Drastic difference between hole and electron injection through the gradient shell of Cd: XSeyZn1- xS1- y quantum dots حسب Abdellah, Mohamed

"…The observed drastic differences between the hole and electron injection are consistent with a model where the hole effective mass decreases, while the gradient shell thickness increases.…"
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Allergenicity of roasted peanuts treated with a non-human digestive protease حسب Yu, Jianmei

"…Results indicate that alcalase digestion of sonicated peanuts significantly increased protein solubility while decreasing Ara h 1 and Ara h 2 concentrations in both soluble and insoluble portions of peanuts relative to untreated peanuts. …"
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Osteoporosis in patients with stroke: A cross-sectional study حسب Tomasevic-Todorovic, Snezana

"…This research was designed as a cross-sectional study that included patients after a first stroke (≤1.5 years from a stroke; N = 40), who went through in-hospital rehabilitation treatment. …"
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Performance Evaluation Of A Msf Desalination Plant In Qatar حسب Okelah, M.R.S.

"…Drop in performance represented by the decrease in the gained output ratio and the increase in energy input per unit distillate as a function of time is evaluated. …"
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Mycoplasma bovis-induced inhibition of bovine peripheral blood mononuclear cell proliferation is ameliorated after blocking the immune-inhibitory programmed death 1 receptor حسب Suleman M.

"…We demonstrated that M. bovis infection induced a significant decrease in CD4+ PD-1INT and CD8+ PD-1INT subsets with intermediate PD-1 expression, which functioned as progenitor pools giving rise to CD4+ PD-1HIGH and CD8+ PD-1HIGH subsets with high PD-1 expression levels. …"
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A process for CO2 capture and brine salinity reduction through reaction with potassium hydroxide: A multi-stage evaluation حسب Mourad, Aya A-H.

"…Solvay and modified Solvay processes are facing a major challenge in reducing brine salinity to a level suitable for agriculture and industry. …"
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A predictive strategy for lifetime maximization in selective relay networks حسب Mousavifar, S.A.

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Caprylamidopropyl Betaine as a Highly Efficient eco-friendly Corrosion Inhibitor for API X120 Steel in 1 M H2SO4 حسب Foudaa, Abd El Aziz S.

"…CORROSION inhibition of API X120 steel in a 1M sulfuric acid solution at altered temperatures was investigated utilizing a new eco-friendly surfactant (Caprylamidopropyl Betaine (CAPB)) by Gravimetric and electrochemical test (containing potentiodynamic polarization (PP), electrochemical impedance spectroscopy (EIS). …"
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Studies of Glyoxalase 1-Linked Multidrug Resistance Reveal Glycolysis-Derived Reactive Metabolite, Methylglyoxal, Is a Common Contributor in Cancer Chemotherapy Targeting the Splic... حسب Alhujaily, Muhanad

"…Background: Tumor glycolysis is a target for cancer chemotherapy. Methylglyoxal (MG) is a reactive metabolite formed mainly as a by-product in anaerobic glycolysis, metabolized by glyoxalase 1 (Glo1) of the glyoxalase system. …"
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Magnesium Intake and Sleep Disorder Symptoms: Findings from the Jiangsu Nutrition Study of Chinese Adults at Five-Year Follow-Up. حسب Cao, Yingting

"…At follow-up in 2007, sleep disorder symptoms, including daytime falling asleep, sleepiness and snoring at night, were gathered using a sleep questionnaire. (3) Results: The mean intake of magnesium was 332.5 mg/day. …"
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Novel potentials of the DPP-4 inhibitor sitagliptin against ischemia-reperfusion (I/R) injury in rat ex-vivo heart model حسب Al-Awar A.

"…Results of CGRP are in line with TRPV-1, as a downstream regulatory effect. NOS system and transient receptor potential (TRP) channels can contribute to DPP-4 inhibition-mediated cardioprotection against I/R injury using Sitagliptin.…"
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Reinfections in COVID-19 Patients: Impact of Virus Genetic Variability and Host Immunity حسب Fakhroo, Aisha

"…Reinfection was attributed to several viral and/or host factors, including (i) underlying immunological comorbidities; (ii) low antibody titers due to the primary infection or vaccination; (iii) rapid decline in antibody response after infection or vaccination; and (iv) reinfection with a different SARS-CoV-2 variant/lineage. …"
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Numerical evaluation of the thermal performance of a near-surface earth-to-air heat exchanger with short-grass ground cover: A parametric study حسب Pakari, Ali

"…By increasing the soil thermal conductivity from 1 to 5 W m−1 K−1 the outlet temperature decreased by about 4.4 °C.…"
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