Effects of cannabinoid receptor antagonism on pancreatic stellate cells. by Christoph W. Michalski (85727)

“…<p>(A) MTT assays after 48 hours' incubation of PSC with graded concentrations of CB1- and CB2-receptor antagonists AM251 and AM630 (p = n.s. for concentrations of 1.25, 2.5 and 5 µM). …”

PIAS1 inhibits the ability of TGFβto suppress E-cadherin promoter activity. by Stuart J. Netherton (152258)

“…Aii) Each column is the mean (± SEM, n = 5) of the percent repression of luciferase activity by TGFβ relative to that of the basal (− TGFβ) of the corresponding transfection as shown in Ai (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0013971#s4" target="_blank">MATERIALS and METHODS</a>). …”

Longitudinal MRI study of changes in BTB permeability and rCBV of brain metastases. by Heling Zhou (368949)

“…All the tumors except one (yellow arrowhead) still kept BTB intact at week 4. rCBV maps were created and rCBV values of the tumors were presented in the table (<b>B</b>). <b>C.</b> A total of 32 lesions in 5 animals were seen on both scans of weeks 3 and 4. rCBV of brain metastases (solid) was initially similar to that of contralateral normal brain (open; mean  = 1.05±0.05 (se) vs. 0.96±0.04), but decreased significantly (p<0.05) and became significantly lower as compared to their contralateral normal brain in the late scan (mean  = 0.88±0.06 vs. 1.00±0.06; p<0.05).…”

Ndrg2 mRNA is induced in wt mice by FXR agonists, reduced in livers of FXR^−/− versus wt mice and both FXR and NDRG2 mRNAs are reduced in human HCC versus normal liver.... by Ulrich Deuschle (129085)

“…Relative mRNA levels of Ndrg2, Shp, Cyp7a1 and Cyclophilin E were determined by RT-qPCR from wt (n = 5) and FXR^−/− (n = 5) mice as indicated. …”

<i>In vitro</i> validation of VH411 phage binding. by Marion David (366485)

“…In the present example, the cells were incubated with the anti-PVIII antibody (1/1000) detected with an allophycocyanine (APC) secondary antibody (1/800) (vertical axis) (B1, B3, B4, B5, B6) and with the anti-LDLR antibody (1/50) detected with a secondary FITC-labeled antibody (1/800) (horizontal axis) (B2, B3, B4, B5, B6). …”

Obesity Partially Mediates the Diabetogenic Effect of Lowering LDL Cholesterol by Peitao Wu (8811071)

Metabolites displaying the highest differences between TCF7L2 risk genotype carriers and controls. by Cornelia Then (81529)

“…Delta t35 (p = 2.7E-03) and t240 (p = 4.2E-03) of PC ae C40:5 are given as a representative example. Data are given as mean and standard error of the mean. * = p ≤ 0.05 after correction for multiple testing.…”

Effect of population size on the magnitude of distortion. by Alexander Coulton (8468724)

“…The dashed lines mark the 5% significance threshold for a chi-square test, whilst the dotted line marks a 1:1 segregation ratio. …”

MPA gap analysis results based upon alternate choices of datasets. by Casey C. O'Hara (3997529)

“…Scenario 2 updates the results using AquaMaps version 08/2015, showing very small changes despite the inclusion of an additional 5,545 species. Scenario 3, still using 2015 AquaMaps data, drops the presence threshold to zero, showing an expected decrease in gap species, but also a decrease in species with 5% or greater protected range. …”

Example simulation of the 2D Ising model. by Manfred Füllsack (4691716)

“…<p>Simulation of the 2D-Ising model with an external magnetic field H taken as critical parameter (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0259177#pone.0259177.e001" target="_blank">Eq 1</a>), on the x-axis, first increasing (H = -0.5 to 0.6, left half) and then decreasing (H = 0.6 to -0.5, right half). …”

Pace Versus Prediction: Is the Experience of the Runner Associated With Marathon Success? by Dan Gordon (2110918)

“…Significant differences observed between PT and FT for all EXP groups apart from EXP-5 (P= 0.0001). EXP-0 showed significant difference across all split times apart from 35-40 km (P=0.0001) with a decrease in normalised speed from 5km (109.0 ±7.6) –40km (89.9 ±7.4%). …”

12-HETE induces phosphorylation of VEGF-R2 and dephosphorylation of protein tyrosine phosphatase (PTP) SHP1 in REC. by Amira Othman (380131)

“…<p>Western blotting analysis (A) demonstrated significant increase in the level of pVEGF-R2 after 5 and 60 minutes from the beginning of treatment with 12-HETE. …”

Stronger evidentiary standards do not reduce the need to publish negative outcomes by Silas Boye Nissen (6815351)

“…Figure 6 Strengthening evidentiary requirements does not necessarily decrease canonization of false facts. In panel A, the false positive rate is α=0.05, the false negative rate is β=0.2, the original belief in the claim is q_0=0.5, and the evidentiary standards are symmetric τ_1=1-τ_0. …”

Halo assay performed in MCF7 cells. by Siddharth Manvati (391250)

“…<p>(a) NDF-nuclear diffusion factor-values showing the extent of DNA damage with increasing concentrations of etoposide (p Value <0.001), (b) Percentage of senescent cell population (using β-gal assay) and Annexin-V positive-apoptotic-cell population (through FACS analysis): showing decrease in senescence and increase in Apoptosis (*p Value <0.05), (c) miR-101 expression (using Real-Time PCR): showing decrease with increasing concentration of etoposide (1 µM, 5 µM and 10 µM) for 12 hrs (**p Value <0.005).…”

ID2 expression is inversely correlated to miR-9 and miR-103. by Daniela Annibali (148125)

“…<p>Ectopic expression of miR-9 and miR-103 decreases ID2. (<b>A</b>) Immunoblotting of ID2 in SK-N-BE (upper panel) and SH-SY5Y (lower panel) cells treated with RA for 3, 6 and 10 days. …”

Chronic CSE treatment induced HIF1α accumulation via enhanced lactate production. by Wenyue Sun (134001)

“…<p>A. HIF1α levels in OKF6 cells were determined after 4 h of culture in glucose-free Krebs buffer containing 3 or 5 mmol/L lactate. …”

OLE reduces plaque burden in the cortex and hippocampus of TgCRND8 mice. by Cristina Grossi (358570)

“…Both Aβ40 and Aβ42 levels were significantly decreased in OLE-fed Tg versus age-matched untreated Tg (n<i> = </i>5/group) mice. …”

Data Sheet 1_Valve-in-valve transcatheter aortic valve replacement (TAVR) leads to lower device success compared to TAVR in native stenosis.pdf by Michael Paukovitsch (16428786)

“…While ViV-TAVR decreased peak and mean gradients significantly, in 31% of patients elevated mean gradients (≥20 mmHg) were observed at discharge. …”

Effects of omega-6/3 and omega-9/6 nutraceuticals on pain and fertility in peritoneal endometriosis in rats by Francisco Edson Ximenes Gomes Pereira (6675698)

“…Fertility was evaluated by counting the number of embryos in the left hemi-uterus. Results: The mean number of writhings was as follows: sham-operated, 11.1 ± 2.9; control with endometriosis, 49.3 ± 4.4; omega-6/3, 31.5 ± 2.7; omega-9/6, 34.1 ± 4.5; medroxyprogesterone acetate, 2.1 ± 0.8; meloxicam, 1 ± 0.3. …”

Figure CSA-2 4.15 by CIMR project (7352015)