Induction of ssDNA at human telomeres. by Remco P. Crefcoeur (3611735)

“…Untransfected, sgControl-, and sgTelomere-transfected cells showed, respectively, 5%, 4%, and 50% colocalization. A total number of 100 cells were counted (p<0.00001).…”

IGFBP3 inhibits HCRT production <i>in vivo</i> and <i>in vitro</i>. by Makoto Honda (102165)

“…<p>(A, B) Hypocretin-1 peptide content is significantly decreased in both hypothalamus and brainstem of IGFBP3 overexpressing transgenic mice (h<i>IGFBP3</i> TG). …”

Steroidogenic cells are induced to undergo an EMT-like change by hemodynamic forces and pFak signaling. by Chih-Wei Chou (143519)

“…The accumulation of β-Catenin at cell-cell junctions in the steroidogenic tissue can be seen in cross sections of <i>Tg(ff1bEx2: GFP)</i> embryos at (F, F') 2 dpf, but not at (G, G') 2.5 dpf. The decrease in junctional β-Catenin was not observed in (H, H') <i>tnnt2a</i> morphants, (I, I') 2,3-BDM- or (J, J') RGD-treated embryos, or (K, K') <i>klf2a</i> or (L, L') <i>mmp2</i> morphants. …”

MSNs degeneration in R6/2 mice. by Catia C. Proenca (431486)

“…Right: quantification of C) shows a highly significant decrease in both NeuF and DARPP-32 intensity. …”

Behavioral health risk profiles of physical education undergraduates by Luciana Zaranza Monteiro (5834810)

“…There is an urgent need for both a formulation and implementation of public health policies to promote health and decrease risk factors for NCCD.…”

Kinases are recruited to the signaling complex by alternative N-t localization domains. by Paloma M. Sato (672126)

“…In most cases, mutations that disrupt specific recruitment interactions decrease pathway activation between 40%–50%. MUT Ste20[N]-Ste50[C] might still localize to the signaling complex, as Ste50's RA domain binds Cdc42 independently of Ste20's PBD domain <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002012#pbio.1002012-Truckses1" target="_blank">[53]</a>. …”

Effects of administering drugs into the TG on the glial fibrillary acidic protein (GFAP)-IR cells. by Hiroharu Maegawa (8087543)

“…A significant decrease was found in the ION-CCI + CGRP Ab group as compared to the ION-CCI, ION-CCI + vehi, ION-CCI + CGRP, and ION-CCI + ctrl IgG groups. *** <i>p</i> < 0.001 as compared to the sham group. ## <i>p</i> < 0.01, # <i>p</i> < 0.05 as compared to the ION-CCI + CGRP Ab group. …”

Cardiac response to Painless activation by elevated temperature. by Sébastien Sénatore (80383)

“…In the wild-type, the increase of temperature from 25°C to 46°C induces a strong arrhythmia with an important decrease in the cardiac rate (−23.7%). …”

Table_1_Early onset age increases the risk of musculoskeletal damage in patients with type 2 diabetes.docx by Biao Zheng (22390)

“…With the prolongation of the course of the disease, the risk of muscle mass and/or bone mineral density decrease in EOT2D increases.</p>Conclusion<p>EOT2D brings a greater risk of sarcopenia and/or osteoporosis, as well as a higher risk of reduced ASM and BMD. …”

Effects of phosphodiesterase inhibitors on epidermal apoptosis after an acute exposure to UVB. by Jamie J. Bernard (645781)

“…<p><b>A.</b> Female SKH-1 hairless mice (7 to 8 weeks old, 5 per group) were treated topically with caffeine or different PDE inhibitors at a concentration of 3.1 µmole (in 100 µl acetone:water (9∶1) right after a single dose of 30 mJ/cm² of UVB and at 30 and 120 min later. …”

Impedimetric quantification of compound efficacy for tau-specific neurodegeneration attenuation and detection of toxic side effects. by Diana Seidel (122737)

“…<p><b>A.</b> Scheme of impedimetric detection of tau-specific neurodegeneration by using our WT and K280q expressing SH-SY5Y 3D culture model. …”

Nitrogen and mepiquat chloride can affect fiber quality and cotton yield by Aguinaldo J. F. Leal (4626469)

“…The experimental design was a randomized blocks in a 5 × 4 factorial scheme comprised of five N doses (0, 40, 80, 120, 160 kg ha-1) and four MC doses (0, 50, 100, 150 mL ha-1) with four repetitions. …”

Densitometric quantitation of differential protein expression in controls and type 1 diabetic patients (T1D). by Franco Folli (195509)

“…SOD1 expression was increased by 2.5-fold and ATP synthase δ chain 2-fold in T1D compared with controls (p<0.01) (<u>A</u>). …”

Acute leptin treatment in chronically food restricted mice does not significantly affect hypothalamic <i>Pomc</i> or <i>Agrp</i> mRNA between genotypes as demonstrated by qPCR. by Elisa S. Na (4114219)

“…<i>Agrp</i> mRNA is not substantially affected by leptin administration but there is a significant decrease in <i>Agrp</i> mRNA in all groups compared to the WT PBS-treated group. …”

Late Quaternary evolution of the southern Brazilian Atlantic coast by Ciro Cerrone (14964274)

“…In particular, the Last Interglacial (LIG; Marine Isotope Stage 5e, ~ 125 ka) is considered a process analogue for understanding the current interglacial because during the LIG higher temperatures than the pre-industrial era led to an increase in the global sea level and decrease in ice sheets volume. …”

Early-Life Hepatitis E Infection in Pigs: The Importance of Maternally-Derived Antibodies by Mathieu Andraud (300301)

“…The impact of PI on hepatitis E virus transmission in piglets was investigated using longitudinal serological data from six pig farms. A strong impact of PI was highlighted, the efficiency of transmission being on average 13 times lower in piglets with maternally-derived antibodies than in fully susceptible animals (range: 5–21). …”

Impact at the leaf assimilation level. by José C. Ramalho (493978)

“…For each parameter, the mean values ± SE (n = 5–8) followed by different letters express significant differences between temperature treatments for the same water availability level (a, b, c, d, e, f), or between water treatments for each temperature treatment (A, B, C), always separately for each genotype.…”

Image_1_Breaking All the Rules: The First Recorded Hard Substrate Sessile Benthic Community Far Beneath an Antarctic Ice Shelf.JPEG by Huw J. Griffiths (9468143)

“…<p>The seafloor beneath floating ice shelves accounts roughly a third of the Antarctic’s 5 million km² of continental shelf. …”

Key regulators of the inner ear transcriptome. by Ronna Hertzano (203344)

“…Scale bar  =  50 µm. See also <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1002309#pgen.1002309.s005" target="_blank">Figure S5</a>. …”

Inhibiting mTORC2 down-regulated TRPC6 protein expression. by Fangrui Ding (659863)

“…(E, F) In podocytes exposed to ku0063794 for 2, 4, 8, 12, or 24 hours, the TRPC6 protein levels were decreased in a time-dependent manner. (G, H) The TRPC6 protein levels were decreased in a concentration-dependent manner following treatment with 0.5, 1, 2, 3, or 4 µmol/l ku0063794 compared to the control group. …”