The protein level of ApoB was decreased in HCV-infected cells. by Bei Wang (116772)

Comparison of our CCR5-CCL5-I and -II systems with the experimental structure (PDB ID: 7O7F), a complex of CCR5 with a modified CCL5 chemokine, the super-agonist [6P4]CCL5. by Guillermo Goode-Romero (11476663)

“…<i>e</i>., helices and beta-sheets) were calculated on our trajectory with respect 7O7F. The predominant decrease in the RMSD of replicate I suggests that our system approximates to the full activated state, despite the bias introduced by the CCL5 mutations in 7O7F. …”

Lifelong Reduction of LDL-Cholesterol Related to a Common Variant in the LDL-Receptor Gene Decreases the Risk of Coronary Artery Disease—A Mendelian Randomisation Study by Patrick Linsel-Nitschke (87537)

“…</p><h3>Findings</h3><p>Each copy of the minor T allele of SNP rs2228671 within <em>LDLR</em> (frequency 11%) was related to a decrease of LDL-C levels by 0.19 mmol/L (95% confidence interval (CI) [0.13–0.24] mmol/L, p = 1.5×10⁻¹⁰). …”

image2_Leonurine-Repressed miR-18a-5p/SOCS5/JAK2/STAT3 Axis Activity Disrupts CML malignancy.tif by Hui-Min Liu (3323370)

“…Treating CML cells with leonurine significantly decreased miR-18a-5p expression. Moreover, we found miR-18a-5p repressed SOCS5 by directly targeting its 3′-UTR. miR-18a-5p downregulation induced by leonurine reduced the biological activity of CML cells by relieving miR-18a-5p repression of SOCS5 expression. …”

image1_Leonurine-Repressed miR-18a-5p/SOCS5/JAK2/STAT3 Axis Activity Disrupts CML malignancy.tif by Hui-Min Liu (3323370)

“…Treating CML cells with leonurine significantly decreased miR-18a-5p expression. Moreover, we found miR-18a-5p repressed SOCS5 by directly targeting its 3′-UTR. miR-18a-5p downregulation induced by leonurine reduced the biological activity of CML cells by relieving miR-18a-5p repression of SOCS5 expression. …”

image3_Leonurine-Repressed miR-18a-5p/SOCS5/JAK2/STAT3 Axis Activity Disrupts CML malignancy.tif by Hui-Min Liu (3323370)

“…Treating CML cells with leonurine significantly decreased miR-18a-5p expression. Moreover, we found miR-18a-5p repressed SOCS5 by directly targeting its 3′-UTR. miR-18a-5p downregulation induced by leonurine reduced the biological activity of CML cells by relieving miR-18a-5p repression of SOCS5 expression. …”

image4_Leonurine-Repressed miR-18a-5p/SOCS5/JAK2/STAT3 Axis Activity Disrupts CML malignancy.tif by Hui-Min Liu (3323370)

“…Treating CML cells with leonurine significantly decreased miR-18a-5p expression. Moreover, we found miR-18a-5p repressed SOCS5 by directly targeting its 3′-UTR. miR-18a-5p downregulation induced by leonurine reduced the biological activity of CML cells by relieving miR-18a-5p repression of SOCS5 expression. …”

Data Sheet 1_Regulation of SLC7A11 by LncRNA GPRC5D-AS1 mediates ferroptosis in skeletal muscle: Mechanistic exploration of sarcopenia.pdf by Wei Gong (112494)

“…In the sarcopenia group, both GPRC5D-AS1 and SLC7A11 expression levels decreased significantly, along with SLC7A11 protein translation. …”

Supplementary file 1_Regulation of SLC7A11 by LncRNA GPRC5D-AS1 mediates ferroptosis in skeletal muscle: Mechanistic exploration of sarcopenia.pdf by Wei Gong (112494)

“…In the sarcopenia group, both GPRC5D-AS1 and SLC7A11 expression levels decreased significantly, along with SLC7A11 protein translation. …”

BA attenuated the decrease in the integrity and increase in the permeability of the epithelial barrier injury induced by LPS in Caco2 cell monolayers. by Luqiong Liu (11537092)

Target specificity, <i>in vivo</i> pharmacokinetics, and efficacy of the putative STAT3 inhibitor LY5 in osteosarcoma, Ewing's sarcoma, and rhabdomyosarcoma by Peter Y. Yu (4281448)

“…The purpose of this work was to develop and test a novel putative STAT3 inhibitor, LY5.</p><p>Methods and findings</p><p>An <i>in silico</i> fragment-based drug design strategy was used to create LY5, a small molecule inhibitor that blocks the STAT3 SH2 domain phosphotyrosine binding site, inhibiting homodimerization. …”

LY5 inhibits STAT3 phosphorylation in lung metastases but does not inhibit lung metastasis formation. by Peter Y. Yu (4281448)

Decreased number of myofibroblasts on stiff-to-soft gels was not due to apoptosis. by Huan Wang (109286)

Acute JMV2959 treatment decreases alcohol intake in rats. by Petra Suchankova (400313)

“…<p>(A) The acute effects of the GHS-R1A antagonist JMV2959 (1 or 3 mg/kg) administration on alcohol intake was evaluated at 1 hour time interval after both two and five months of voluntary alcohol consumption. …”

Acute JMV2959 treatment decreases alcohol preference in rats. by Petra Suchankova (400313)

“…<p>(A) Acute administration of the GHS-R1A antagonist JMV2959 (1 or 3 mg/kg) decreases the alcohol preference compared to vehicle at 1 hour time interval in rats voluntarily consuming alcohol for two and five months before the treatment. …”

Inhibition of the lysosomal protease decreased the apoptosis induced by EV71. by Xueyan Xi (5654083)

Cellular viability decreases in breast cancer cells treated with clotrimazole. by Cristiane M. Furtado (333360)

Procedure for decreasing the required time for fire resistance of the multistory buildings by V. P. SILVA (4642840)

Decreased TORC1 activates HPK-1 to extend longevity. by Ritika Das (4514968)

Destroying of microtubule network with colchicine decreases ENaC activity. by Alexey V. Karpushev (367701)