Fluorescence Imaging of Neuroblastocyte Differentiation and Parkinson’s Brain Tissue Lesions Examined by a Norepinephrine-Activated Molecular Probe by Huming Yan (9917374)

“…Fluorescent probes combined with high-resolution microscopy imaging techniques have shown outstanding advantages in biological <i>in situ</i> imaging research. Here, we have developed a NE-specific recognition molecular probe, <i><b>DQF</b></i>, by covalently linking the high molar extinction coefficient black-hole quencher BBQ-650 with a fluorescent reporter group, utilizing the fluorescence resonance energy transfer mechanism for prequenching fluorescence. …”

Target specificity, <i>in vivo</i> pharmacokinetics, and efficacy of the putative STAT3 inhibitor LY5 in osteosarcoma, Ewing's sarcoma, and rhabdomyosarcoma by Peter Y. Yu (4281448)

“…The purpose of this work was to develop and test a novel putative STAT3 inhibitor, LY5.</p><p>Methods and findings</p><p>An <i>in silico</i> fragment-based drug design strategy was used to create LY5, a small molecule inhibitor that blocks the STAT3 SH2 domain phosphotyrosine binding site, inhibiting homodimerization. …”

Reverse activation tendency decreases for spikes occurring later in SWRs by Jozsef Csicsvari (82625)

LY5 inhibits STAT3 phosphorylation in lung metastases but does not inhibit lung metastasis formation. by Peter Y. Yu (4281448)

FGF10 dose dependency of the cellular response in E13.5 (black) and E14.5 (blue) epithelium. by Hisako Takigawa-Imamura (3175320)

Fig 5 - by Melissa A. Johnson (3847954)

Fluid loss and hydration in CON (n = 22) and HOT (n = 17) surgeries; Decrease in body mass in kg (A), decrease in body mass in % of total body mass (B), rate of decrease in body ma... by Zehra Palejwala (7507409)

Average changes in (A) spontaneous AP firing rate, (B) ATP and (C) cAMP by decreasing CaMKII activity with KN-93 (high-3 µmol/L, low-0.5 µmol/L), AIP (high-10 µmol/L, low-2 µmol/L), or decreasing calmodulin activity by W-7 (high-50 µmol/L, low-20 µmol/L). by Yael Yaniv (162548)

Average size of church forests in the region is small, 5.42 (+/- 0.34 ha). by Catherine L. Cardelús (6429320)

Binding affinity determination of ACE2 variants with SARS-CoV-2 Spike. by Stuart A. MacGowan (11326845)

We estimated the frame-shift mutation rate in the real genomes, and in randomized genomes without context-dependent codon choice by Roger M Wanner (93314)

Dosimetric comparison of five different techniques for craniospinal irradiation across 15 European centers: analysis on behalf of the SIOP-E-BTG (radiotherapy working group) by Enrica Seravalli (4862974)

“…Modern techniques (IMRT, VMAT, TomoTherapy^®, proton pencil beam scanning [PBS]) are applied in a limited number of centers. For a 14-year-old patient, we aimed to compare dose distributions of five CSI techniques applied across Europe and generated according to the participating institute protocols, therefore representing daily practice.…”

Tun increases mitochondrial fission, inflammatory cell infiltration, and decreased ER-mitochondria interaction in neonatal rat lungs. by Kirkwood A. Pritchard Jr. (13449794)

“…The decreased expressions of GRP75 (0.5±0.2-fold, p = 0.006767, n = 5) and acyl-CoA synthetase long-chain family member 4 (ASCL4; 0.3±0.1-fold, p<0.001, n = 5) indicate a decreased interaction between ER and mitochondria by Tun. …”

MEK1/2 inhibition promotes invasive-opposing leading edge lamellipodial structures in 3-D by increasing localised Rac1 activity and decreasing localised RhoA activity. by Joseph H. R. Hetmanski (2656735)

Gossypol prevents bleomycin-induced pulmonary fibrosis. by Jennifer L. Judge (5278415)

Multiple regulatory mechanisms of <i>MUC5AC</i> gene expression. by Natsuko Kageyama-Yahara (381133)

Expression profiles of Gli and MUC5AC in various tumor cell lines and human normal tissues. by Natsuko Kageyama-Yahara (381133)

Sost and Sclerostin Expression are Decreased and Wnt Signaling is Increased in DMP1-caPTHR1 Transgenic Mice. by Charles A. O'Brien (271071)

A priori model predictions. by Adam M. Roth (19845864)

A summary of calibration standards (n = 3). by Ewa Paszkowska (21246702)

“…<div><p>Purpose</p><p>Statins are the most commonly used drugs worldwide. Besides a significant decrease in cardiovascular diseases (CVDs) risk, the use of statins is also connected with a broad beneficial pleiotropic effect. …”