Treatment effects of fingolimod in multiple sclerosis: Selective changes in peripheral blood lymphocyte subsets by Maria Hjorth (337684)

“…<div><p>Background</p><p>Treatment with fingolimod reduces inflammation in multiple sclerosis (MS) by inhibiting lymphocyte egress from lymph nodes. We aimed to map, in detail, the alterations in peripheral blood lymphocyte subpopulations in relation to clinical outcome in MS patients treated with fingolimod.…”

Supplementary Material for: An Open-label, Uncontrolled, Single-arm Clinical trial of Tofacitinib, an oral JAK1 and JAK3 kinase inhibitor, in Chinese patients with keloid by Chen J.Y. (16730067)

“…Objectives: This study aimed to investigate the efficacy and therapeutic mechanism of oral tofacitinib in keloid patients. Methods: We recruited the seven patients with keloid scars and prescribed 5 mg of tofacitinib twice a day orally with a maximum follow-up of 12 weeks. …”

Comparison of cell clustering behavior in simulations with experiments. by Rajesh Balagam (135557)

“…[<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004474#pcbi.1004474.ref016" target="_blank">16</a>]) for non-reversing (A) and reversing (B) cells. …”

Inhibition of Acetylcholinesterase by Coumarin-Linked Amino Acids Synthetized via Triazole Associated with Molecule Partition Coefficient by Bianca L. de Sousa (10436634)

“…<div><p>A previous study for the identification of acetylcholinesterase (AChE) inhibitors demonstrated that the hybrid between tyrosol, the 1,2,3-triazole nucleus, and the coumarin group, namely 7-({1-[2-(4-hydroxyphenyl)ethyl]-1H-1,2,3-triazol-4-yl}methoxy)-4-methyl-2H-chromen-2-one (10), has a high enzyme inhibitory activity. …”

Image_7_Tilapia Piscidin 4 (TP4) Reprograms M1 Macrophages to M2 Phenotypes in Cell Models of Gardnerella vaginalis-Induced Vaginosis.jpeg by Chia-Wen Liu (708076)

“…Further, we found that direct treatment with TP4 switched M1 macrophages toward a resolving M2c phenotype via the MAPK/ERK pathway and IL-10-STAT3 signaling. …”

DataSheet_1_The sparing effect of ultra-high dose rate irradiation on the esophagus.docx by Wenting Ren (4162672)

“…Label-free quantitative proteomic analysis revealed that the sparing effect observed in the FLASH group may be attributed to a reduction in radiation-induced protein damage associated with mitochondrial functions, including proteins involved in the tricarboxylic acid cycle and oxidative phosphorylation, as well as a decrease in acute inflammatory responses.…”

Image_4_Tilapia Piscidin 4 (TP4) Reprograms M1 Macrophages to M2 Phenotypes in Cell Models of Gardnerella vaginalis-Induced Vaginosis.jpeg by Chia-Wen Liu (708076)

“…Further, we found that direct treatment with TP4 switched M1 macrophages toward a resolving M2c phenotype via the MAPK/ERK pathway and IL-10-STAT3 signaling. …”

Image_1_Tilapia Piscidin 4 (TP4) Reprograms M1 Macrophages to M2 Phenotypes in Cell Models of Gardnerella vaginalis-Induced Vaginosis.jpeg by Chia-Wen Liu (708076)

“…Further, we found that direct treatment with TP4 switched M1 macrophages toward a resolving M2c phenotype via the MAPK/ERK pathway and IL-10-STAT3 signaling. …”

Image_6_Tilapia Piscidin 4 (TP4) Reprograms M1 Macrophages to M2 Phenotypes in Cell Models of Gardnerella vaginalis-Induced Vaginosis.jpeg by Chia-Wen Liu (708076)

“…Further, we found that direct treatment with TP4 switched M1 macrophages toward a resolving M2c phenotype via the MAPK/ERK pathway and IL-10-STAT3 signaling. …”

DataSheet_1_Towards detection of early response in neoadjuvant chemotherapy of breast cancer using Bayesian intravoxel incoherent motion.pdf by Sai Man Cheung (12259900)

“…</p>Results<p>The perfusion fraction showed a significant difference (p = 0.042) in percentage change between responder groups at Cycle 1, with a decrease in good responders [−7.98% (−19.47–1.73), n = 7] and an increase in poor responders [10.04% (5.09–28.93), n = 9]. …”

Table_1_Tilapia Piscidin 4 (TP4) Reprograms M1 Macrophages to M2 Phenotypes in Cell Models of Gardnerella vaginalis-Induced Vaginosis.docx by Chia-Wen Liu (708076)

“…Further, we found that direct treatment with TP4 switched M1 macrophages toward a resolving M2c phenotype via the MAPK/ERK pathway and IL-10-STAT3 signaling. …”

Image_3_Tilapia Piscidin 4 (TP4) Reprograms M1 Macrophages to M2 Phenotypes in Cell Models of Gardnerella vaginalis-Induced Vaginosis.jpeg by Chia-Wen Liu (708076)

“…Further, we found that direct treatment with TP4 switched M1 macrophages toward a resolving M2c phenotype via the MAPK/ERK pathway and IL-10-STAT3 signaling. …”

Image_2_Tilapia Piscidin 4 (TP4) Reprograms M1 Macrophages to M2 Phenotypes in Cell Models of Gardnerella vaginalis-Induced Vaginosis.jpeg by Chia-Wen Liu (708076)

“…Further, we found that direct treatment with TP4 switched M1 macrophages toward a resolving M2c phenotype via the MAPK/ERK pathway and IL-10-STAT3 signaling. …”

Summary of key results. by John R. Houser (783591)

“…On the other hand, relative levels of mRNA decreased upon entry to stationary phase perhaps as a strategy for reducing overall protein synthesis. …”

MRI Correlates of Neurocognitive Functioning in Movement Disorders.docx by Jordan Davis (20398481)

Fibronectin normalizes the responsiveness of cKO cells. by Nina Kawelke (194831)

“…<p>(<b>A</b>) Active TGF-β in the medium decreases significantly both in control and Mx-cKO cells in the presence of fibronectin coating. …”

Polymorphisms in the <i>MASP1</i> Gene Are Associated with Serum Levels of MASP-1, MASP-3, and MAp44 by Christian Gytz Ammitzbøll (116780)

“…Being e.g. homozygote for the minor allele of rs3774275 was associated with an increase in median concentration of 13% in MASP-1(P=0.03), 29% in MAp44 (P<0.001), and a decrease in MASP-3 of 26% (P<0.001) compared to homozygosis for the major allele. …”

Dataset for: Effect of preceding stimulation on sound localization and its representation in the auditory midbrain by Sandra Tolnai (3359648)

“…The smallest thresholds were found after the presentation of a train of five reference stimuli and after silence. We recorded from units in the inferior colliculus (IC) of anaesthetised gerbils using virtual-acoustic space stimuli mimicking the ones used in the behavioral task and applied signal detection theory to compare behavioral and neurometric thresholds. …”

Datasheet1_Comparison of effective regurgitant orifice area by the PISA method and tricuspid coaptation gap measurement to identify very severe tricuspid regurgitation and stratify... by Yohann Bohbot (10860003)

“…Four-year survival was comparable between patients with an EROA <60 mm² vs. ≥60 mm² (68 ± 3% vs. 64 ± 5%, p = 0.89). A TCG ≥10 mm was associated with lower four-year survival than a TCG <10 mm (53 ± 7% vs. 69 ± 3%, p < 0.001). …”

Table_2_Multi-omics analysis identifies IgG2b class-switching with ALCAM-CD6 co-stimulation in joint-draining lymph nodes during advanced inflammatory-erosive arthritis.docx by H. Mark Kenney (10320665)

“…Integration of single-cell and spatial transcriptomics revealed the increased IgG2b⁺ plasma cells localized in MARCO⁺ peri-follicular medullary sinuses. A concomitant decreased Fth1 expression (Early 2.5 ± 0.74 vs Advanced 1.0 ± 0.50 counts, p<0.001) within Advanced PLN sinuses was associated with accumulation of iron-laden Prussian blue positive macrophages in lymph nodes and synovium of Advanced TNF-Tg mice, and further validated in RA clinical samples. …”