Table_1_Liver-Specific Knockdown of Class IIa HDACs Has Limited Efficacy on Glucose Metabolism but Entails Severe Organ Side Effects in Mice.docx by Nicole Ziegler (6893297)

“…For that, siRNAs selectively targeting HDAC4, 5 and 7 were selected and used to achieve a combinatorial knockdown of these three class IIa HDAC isoforms. …”

DataSheet_1_Methylation-mediated silencing of EDN3 promotes cervical cancer proliferation, migration and invasion.xlsx by Peng Zhu (277243)

“…EDN3 silencing mediated by methylation can be blocked by 5-Azacytidine (5-Aza), a DNA methyltransferase 1 (DNMT1) inhibitor, treatment in cervical cancer cell lines. …”

Supplementary Material for: Dynamic profiling of the immune tumor microenvironment in locally advanced gastric cancer treated with perioperative chemotherapy by Donna R. Newman (545370)

Table_1_Methylation-mediated silencing of EDN3 promotes cervical cancer proliferation, migration and invasion.docx by Peng Zhu (277243)

“…EDN3 silencing mediated by methylation can be blocked by 5-Azacytidine (5-Aza), a DNA methyltransferase 1 (DNMT1) inhibitor, treatment in cervical cancer cell lines. …”

Table_2_Functional and Morphological Characterization of Small and Large Steroidogenic Luteal Cells From Domestic Cats Before and During Culture.DOCX by Michał M. Hryciuk (7862249)

“…The cells were cultured for 3 or 5 days without gonadotropins. Isolated feline SLC and LLC had different sizes (12 ± 3 μm vs. 34 ± 5 μm, respectively), morphologies (amount of lipid droplets) and behaved differently in culture. …”

image1_Intracolonic Mustard Oil Induces Visceral Pain in Mice by TRPA1-Dependent and -Independent Mechanisms: Role of Tissue Injury and P2X Receptors.pdf by Rafael Gonzalez-Cano (5157827)

“…<p>Both TRPA1 and purinergic P2X receptors have been proposed as potential targets for the treatment of visceral pain. We found that the intracolonic administration of a low dose mustard oil (0.5%), a well-known TRPA1 agonist, produced nociceptive responses and abdominal wall referred mechanical hyperalgesia, without inducing apparent tissue damage. …”

Table_1_Phytosulfokine alpha enhances regeneration of transformed and untransformed protoplasts of Brassica oleracea.pdf by Valentin Vogrinčič (17968460)

“…We therefore tested whether PSK-α could increase cell division at the early stages of culture (5 and 15 days after protoplast isolation) and stimulate the formation of microcallus colonies up to the 30st day of culture and to evaluate its influence on callus organogenesis leading to shoot regeneration. …”

Defective autophagy in osteoblasts induces endoplasmic reticulum stress and causes remarkable bone loss by Huixia Li (739049)

“…The trabecular bone volume of <i>Atg7</i> cKO mice was significantly lower than that of controls at 5 months of age. This phenotype was attributed to decreased osteoblast formation and matrix mineralization, accompanied with an increased osteoclast number and the extent of the bone surface covered by osteoclasts as well as an elevated secretion of <i>TNFSF11/RANKL</i> (tumor necrosis factor [ligand] superfamily, member 11), and a decrease in <i>TNFRSF11B/OPG</i> (tumor necrosis factor receptor superfamily, member 11b [osteoprotegerin]). …”

VpsO-503 does not undergo tyrosine trans autophosphorylation <i>in vitro</i>. by Carmen Schwechheimer (9300303)

“…<p><b>(A)</b> [γ-³²P]-ATP kinase assay as in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1008745#ppat.1008745.g005" target="_blank">Fig 5E</a>. Where indicated, VpsO-503 was incubated with the catalytically inactive GST-VpsO-503^K551A. …”

DataSheet_1_Non-steroidal anti-inflammatory drugs and clinical outcomes in patients with COVID-19.docx by Jing Zhang (23775)

“…A total of 476 hospitalized patients with COVID-19 were included; 412 patients (86.5%) did not receive NSAIDs, while 64 patients (13.5%) took NSAIDs as regular home medication. …”

Supplementary Material for: Rationale and Design of a Randomized Placebo-Controlled Clinical Trial Assessing the Renoprotective Effects of Potassium Supplementation in Chronic Kidn... by Gritter M. (5468213)

“…Patients who do not subsequently develop hyperkalemia (defined as serum K⁺ >5.5 mmol/L) will be randomized to receive potassium chloride, potassium citrate (both K⁺ 40 mmol/day), or placebo for 2 years. …”

DataSheet_1_Methylation-mediated silencing of EDN3 promotes cervical cancer proliferation, migration and invasion.xlsx by Peng Zhu (277243)

“…EDN3 silencing mediated by methylation can be blocked by 5-Azacytidine (5-Aza), a DNA methyltransferase 1 (DNMT1) inhibitor, treatment in cervical cancer cell lines. …”

Image_2_Liver-Specific Knockdown of Class IIa HDACs Has Limited Efficacy on Glucose Metabolism but Entails Severe Organ Side Effects in Mice.TIF by Nicole Ziegler (6893297)

“…For that, siRNAs selectively targeting HDAC4, 5 and 7 were selected and used to achieve a combinatorial knockdown of these three class IIa HDAC isoforms. …”

DataSheet1_Treatment with paeoniflorin increases lifespan of Pseudomonas aeruginosa infected Caenorhabditis elegans by inhibiting bacterial accumulation in intestinal lumen and bio... by Yuxing Wang (701108)

“…In addition, 2.5–10 mg/L paeoniflorin treatment could inhibit the swimming, swarming, and twitching motility of P. aeruginosa, and treatment with 2.5–10 mg/L paeoniflorin reduced the cyclic-di-GMP (c-di-GMP) level. …”

Data_Sheet_1_Nitrogen Use Efficiency, Allocation, and Remobilization in Apple Trees: Uptake Is Optimized With Pre-harvest N Supply.docx by Bi Zheng Tan (10898982)

“…In the 2017–2018 season, 30 g N tree⁻¹ of 5.5 atom% ¹⁵N–calcium nitrate was applied by weekly fertigation in four equal doses, commencing either 4 weeks after full bloom (WAFB) (pre-harvest) or 1-week post-harvest, or fortnightly, divided between pre- and post-harvest (50:50 split). …”

Roflumilast-Mediated Phosphodiesterase 4D Inhibition Reverses Diabetes-Associated Cardiac Dysfunction and Remodeling: Effects Beyond Glucose Lowering by Rui Xu (158313)

“…Mice on HFD developed diabetes and cardiac dysfunction with increased cardiac PDE4D5 expression. PDE4 inhibitor roflumilast can reverse hyperglycemia and cardiac dysfunction, accompanied by the decrease of PDE4D expression and increase of muscle-specific microRNA miR-1 level in hearts. …”

DataSheet2_A new perspective on selenium’s impact on renal function: European population-based analysis of plasma proteome-mediated Mendelian randomization study.pdf by Shaojie Fu (9658334)

“…In the enrichment analysis, 13 signal transduction pathways, including FGFR4 mutant receptor activation and Defective SLC5A5 causing thyroid dyshormonogenesis 1, were involved in the effect of selenium on eGFR levels.…”

Data_Sheet_1_Influence of the First Wave of the COVID-19 Pandemic on Cancer Care in a German Comprehensive Cancer Center.docx by Johanna Kirchberg (11745386)

“…During the first shutdown, March–May 2020, the total number of presentations was 9.4% (−18.7, 1) less than during March–May 2019. This decrease was significant for curable cases of esophageal cancer [N = 37, 25.5% (−41.8, −4.4)] and colon cancer [N = 36, 17.5% (−32.6, 1.1)] as well as for all cases of biliary tract cancer [N = 26, 50% (−69.9, −15)] during the first shutdown from March 2020 to May 2020.…”

DataSheet1_A new perspective on selenium’s impact on renal function: European population-based analysis of plasma proteome-mediated Mendelian randomization study.pdf by Shaojie Fu (9658334)

“…In the enrichment analysis, 13 signal transduction pathways, including FGFR4 mutant receptor activation and Defective SLC5A5 causing thyroid dyshormonogenesis 1, were involved in the effect of selenium on eGFR levels.…”

Data_Sheet_4_Gut Microbes Reveal Pseudomonas Medicates Ingestion Preference via Protein Utilization and Cellular Homeostasis Under Feed Domestication in Freshwater Drum, Aplodinotu... by Changyou Song (12754616)

“…The results indicated that a significant increase in the final body weight was exhibited by the feed domesticated group (DOM, 114.8 g) when compared to the group that did not ingest the feed (WT, 5.3 g) as the latest version we raised From the result, the final body weight exhibited significant increase between unfavorable with the feed (WT, 5.3 g) and feed domesticated group (DOM, 114.8 g). …”