A Single Amino Acid Deletion (ΔF1502) in the S6 Segment of Ca_V2.1 Domain III Associated with Congenital Ataxia Increases Channel Activity and Promotes Ca²⁺ In... by Maria Isabel Bahamonde (840859)

“…ΔF1502 strongly decreases the voltage threshold for channel activation (by ~ 21 mV), allowing significantly higher Ca²⁺ current densities in a range of depolarized voltages with physiological relevance in neurons, even though maximal Ca²⁺ current density through ΔF1502 Ca_V2.1 channels is 60% lower than through wild-type channels. …”

Intrathecal (i.t.) pretreatment with EphB1-Fc inhibited formalin-induced inflammatory pain and spinal Fos protein expression, accompanied by the decreased expression of spinal PI3K... by Li-Na Yu (312492)

“…The expression of spinal Fos protein and spinal PI3K-p110γ and p-AKT was measured at 2-h and 30-min after injection of formalin, respectively. (A) Pretreatment of EphBs receptors blocker EphB1-Fc (0.5 µg) decreased the time of licking paw and the number of flinching paw induced by formalin. …”

Expression profiling in APP23 mouse brain: inhibition of Aβ amyloidosis and inflammation in response to LXR agonist treatment-4 by Iliya Lefterov (73826)

“…Note that T0 decreases iNOS even bellow its basal level if applied with Aβ (in , veh versus Aβ+T0, p < 0.01). …”

Cyclosporine Inhibits a Direct Interaction between Cyclophilins and Hepatitis C NS5A by Fiona Fernandes (251389)

“…Mutations in NS5A alone conferred decreased CsA susceptibility regardless of NS5B mutations.…”

Macroscopic and microscopic aspects of healthy hamster cheek pouches (a and b) or cheek pouches from animals subjected to 5-fluorouracil (5-FU)-induced oral mucositis and that rece... by Maria Adriana Skeff (670466)

Whole genome sequencing snapshot of multi-drug resistant <i>Klebsiella pneumoniae</i> strains from hospitals and receiving wastewater treatment plants in Southern Romania by Marius Surleac (8378823)

“…Moreover, some ARGs (<i>oqxA10</i>; <i>bla</i>_SHV-145; <i>bla</i>_SHV-100, <i>aac(6')Il</i>, <i>aph(3')VI</i>, <i>armA</i>, <i>arr2</i>, <i>cmlA5</i>, <i>bla</i>_CMY-4, <i>mphE</i>, <i>msrE</i>, <i>oqxB13</i>, <i>bla</i>_OXA-10) showing decreased prevalence in influent <i>versus</i> effluent wastewater samples could be used as markers for the efficiency of the WWTPs in eliminating AR bacteria and ARGs. …”

Effects of 20 μM 5-aza-dC Treatment on the 10q25 Neocentromere by Nicholas C Wong (14627)

“…Six CpG islets (28, 31, 69, 70, 71, and 101) showed an increase in DNA methylation upon the formation of the 10q25 neocentromere. However, following 5-aza-dC treatment, the methylation level of these CpG islets decreased significantly. …”

Interferon induced protein 35 exacerbates H5N1 influenza disease through the expression of IL-12p40 homodimer by Anshu P. Gounder (626041)

“…The host Interferon Induced Protein 35 (Ifi35) has been implicated in increased susceptibility to H5N1-IAV infection. Here, we show that Ifi35 deficiency leads to reduced morbidity in mouse models of highly pathogenic H5N1- and pandemic H1N1-IAV infection. …”

Bioinspired <i>In Vitro</i> Brain Vasculature Model for Nanomedicine Testing Based on Decellularized Spinach Leaves by Aleksandra L. Predeina (11741029)

Bioinspired <i>In Vitro</i> Brain Vasculature Model for Nanomedicine Testing Based on Decellularized Spinach Leaves by Aleksandra L. Predeina (11741029)

Bioinspired <i>In Vitro</i> Brain Vasculature Model for Nanomedicine Testing Based on Decellularized Spinach Leaves by Aleksandra L. Predeina (11741029)

Data Sheet 1_Comparison between 75-g and 100-g oral glucose tolerance tests using international association of diabetes and pregnancy study group one-step diagnostic threshold to d... by Li-Li Zhou (1710085)

“…However, from fasting to 2h, the 100g group showed a steeper rise than the 75g group [Difference in slope (95% CI):0.412 (0.244 to 0.580), p<0.05], and a slower decline between 1-2h [Difference in slope (95% CI):0.047 (0.010 to 0.084), p<0.05].Glucose-adjusted continuous analysis showed that blood glucose levels were mostly associated with adverse outcomes, with the strength of association gradually decreasing from fasting to 1h and 2h. …”

Adolescent intermittent ethanol (AIE) exposure leads to global reductions of choline acetyltransferase (ChAT)-immunopositive cells in the young adult brain. by Ryan P. Vetreno (663148)

ULK1-ATG13 and their mitotic phospho-regulation by CDK1 are required for cell cycle progression. by Zhiyuan Li (205620)

Noggin Over-Expressing Mouse Embryonic Fibroblasts and MS5 Stromal Cells Enhance Directed Differentiation of Dopaminergic Neurons from Human Embryonic Stem Cells by Mi-Sun Lim (5665255)

“…This was done using γ-irradiated noggin-overexpressing CF1-mouse embryonic fibroblasts (MEF-noggin) and MS5 stromal cells (MS5-noggin and MS5-sonic hedgehog). …”

Data Sheet 5_Time-updated patterns of hemoglobin and hematocrit and the risk of CKD progression.docx by Li-zhe Fu (14825593)

“…Group 1 (“lower and decreasing”) (Hb<100 g/L, HCT approximately 30%) served as the reference. …”

<i>SLC2A2</i> is essential for liver differentiation in developing vertebrates by Yejin Kim (740789)

“…Total RNA was isolated from uninjected control and <i>SLC2A2</i> MO‐injected embryos (2.5, 5, and 10 ng). (B) Lateral view of zebrafish embryos after <i>SLC2A2</i> MO-injection (2.5, 5, and 10 ng). …”

Loss of <i>SLC4A11</i> expression and CHED-associated <i>SLC4A11</i> mutations in hCEnC lead to decreased cell viability during tBH-induced oxidative stress. by Doug D. Chung (3611387)

Knocking down both HIF-1α and HIF-2α attenuated c-Myc degradation by Ni ions and hypoxia in A549 cells. by Qin Li (36669)

“…(B) 100 µM DFO, 1 mM DMOG, and hypoxia (1% O₂) decreased c-Myc protein levels in A549 cells in a time-dependent manner. …”

Effects of Gβ5 and Gβ1 coexpression on agonist-induced receptor internalization. by J. Christopher Octeau (622081)

“…The bars represent the percentage decrease in cell surface D2R in each transfection condition compared to corresponding cells that were not treated with dopamine (mean ± SEM; n = 8, *p<0.01, t-test, compared to cell surface D2R signal from corresponding cells not treated with dopamine). …”