Dissolving microneedle patches for transdermal delivery of paroxetine: <i>in-vitro, ex-vivo</i> studies and its PBPK modeling by Muhammad Sikandar (13449684)

“…</p> <p>MNPs from the optimized formulation successfully created microchannels in rat skin, demonstrated higher permeation than control MNPs with a flux of 146.18 ± 13.42 µg/cm²/h, presented a decrease in lag phase and an increase in drug plasma C_max and AUC compared to PAXIL CR 12.5 mg oral, and showed higher stability in the room and refrigerator conditions.…”

Efficacy of treatment strategies (see Table 1) in preventing subsequent seizures and mortality in STZ rats. by Margaret Maheandiran (503654)

“…<p><b>A</b>: BG decrease is not significantly different in seizing animals regardless of treatment; <b>glu</b>: seizure+ survival (S+S Glu), <b>ac+1xglu</b>: S+S AC, <b>glu</b>: seizure + mortality (S+M Glu), <b>ac+1xglu</b>: S+M AC (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0083168#pone-0083168-t004" target="_blank">Table 4</a>). …”

The combined lithostratigraphic and environmental data. by Samuel M. Hudson (2671240)

“…The landscape summary determined from the plant sedaDNA evidence is as follows. 1- Willow woodland within floodplain. 2- More open local landscape with willow in floodplain alongside elm and increased shrubs on terrace edge. 3- Open local landscape with slight decrease in wood/shrub taxa, increases in wetland forbs and first appearance of sedge taxa. 4- Continued open local landscape with increased woodland and graminoid diversity, alongside increasing dryland forb community. 5- Continued open local landscape with clear increases in wet and dry woodland, graminoid and forb diversity. …”

Mitochondrial respiration presented as oxygen flux (O₂ flux, pmol^.s^-1.mg^-1) in skeletal muscle in Non-raced and Raced Alaskan Huskies. by Benjamin Miller (3954770)

“…In the Raced dogs there was a significant decrease in both FAO_L and FAO_P (A). …”

Effects of Glutamine on Digestive Function and Redox Regulation in the Intestines of Broiler Chickens Challenged with Salmonella Enteritidis by Q Wu (7511207)

“…Enteritidis infection led to a decrease in the average body weight at d 7, 14, and 21 (p<0.05). …”

Denaturant-dependent refolding and unfolding kinetics of CcdB mutant proteins (related to Fig 2). by Gopinath Chattopadhyay (9365504)

“…<p>(A-E) Representative refolding rate constants of fast phase (left side) and slow phase (right panel) and (F-H) unfolding rate constants at 5 μM protein concentration of the WT and mutants are shown. …”

Effect of <i>Phanerochaete chrysosporium</i> on the Oxidation Characteristics of Coal Spontaneous Combustion with High Sulfur by Xin Yi (180644)

“…The ignition temperature points of two types of high sulfur coal shifted toward higher temperatures, with the maximum shift of 3.99°C. The average activation energy (<i>E</i>_a) of the two types of high sulfur coal increased by 59.5 kJ/mol and 28.49 kJ/mol, with the maximum growth rate of 53.58%. …”

<i>F. scutaria</i> sperm were sensitive to cryoprotectants (no sperm exposed to freezing in any of these treatments). by Mary Hagedorn (319120)

“…Note on Day 1 and 2, the toxicity of 10% DMSO was high (low motility), whereas on Day 3 it was low (high motility). <b>C</b>) In contrast, 10% DMSO and PG solutions caused a 30 to 40% decrease in fertilization success for fresh <i>F. scutaria</i>, whereas the 5% solutions did not. …”

Radiological images of bone cancer-bearing rat femurs. by Louis Doré-Savard (238428)

“…Throughout the entire bone structure, proportional bone content is significantly modified from day 14, with a greater decrease in bone percentage at day 21. …”

Proposed model to explain the down-regulation of PRPS1 in HGPS. by Jesús Mateos (4634137)

“…High glycolitic rate in HGPS drives to a decrease in the levels of D-Ribose-5-phosphate available for <i>de novo</i> purine synthesis. …”

Chelation and Stereodynamic Equilibria in Neutral Hypercoordinate Organosilicon Complexes of 1‑Hydroxy-2-pyridinone by Bradley M. Kraft (1859533)

“…Significant weakening of the dative Si←OC bond in <b>3</b> is observed in the cocrystallized adduct solvate <b>3</b>·Ph₃SiOH·¹/₂C₅H₁₂, providing structural evidence for the decrease in coordination number of the OPO ligand by hydrogen-bonding donors. …”

Thermal Manipulation during Embryogenesis Has Long-Term Effects on Muscle and Liver Metabolism in Fast-Growing Chickens by Thomas Loyau (624425)

“…The aim of this study was to evaluate the long-term effects of TM (12 h/d, 39.5°C, 65% RH from d 7 to 16 of embryogenesis vs. 37.8°C, 56% RH continuously) and of a subsequent heat challenge (32°C for 5 h at 34 d) on the mRNA expression of metabolic genes and cell signaling in the <i>Pectoralis major</i> muscle and the liver. …”

Categorising trajectories and individual item changes of the North Star Ambulatory Assessment in patients with Duchenne muscular dystrophy by Francesco Muntoni (228210)

“…Using the NorthStar Clinical Network database, 395 patients with >1 NSAA assessment were identified. We utilised latent class trajectory analysis of longitudinal NSAA scores, which produced evidence for at least four clusters of boys sharing similar trajectories versus age in decreasing order of clinical severity: 25% of the boys were in cluster 1 (NSAA falling to ≤ 5 at age ~10y), 35% were in cluster 2 (NSAA ≤ 5 ~12y), 21% in were cluster 3 (NSAA≤ 5 ~14y), and 19% in cluster 4 (NSAA > 5 up to 15y). …”

Reduction of proliferative neural progenitor cells in the nCT brain. by Sunny Li-Yun Chang (275903)

“…<p>A1-B2: BrdU pulse-labeled cells in the germinal zone were decreased in the LGE of E11.5 nCT brain (A2) compared to that in the nC brain (A1). …”

Table 1_Apparent reduction in heart rate during oviposition revealed by non-invasive heart rate monitoring of gravid loggerhead turtles.xls by Tomoko Narazaki (421081)

“…However, a significant decrease in heart rate, often accompanied by increased RMSSD, was observed during egg-laying, suggesting parasympathetic nervous system dominance during this phase. …”

Establishing and validating noninvasive prenatal testing procedure for fetal aneuploidies in Vietnam by Minh-Duy Phan (198730)

Data_Sheet_1_Variation and Variability in Drosophila Grooming Behavior.pdf by Joshua M. Mueller (6882605)

“…Here, we investigate genetic differences as a possible source of variation and variability in Drosophila grooming. …”

Data_Sheet_1_Dynamic Changes in the Phenotype of Dendritic Cells in the Uterus and Uterine Draining Lymph Nodes After Coitus.PDF by Ippei Yasuda (9364253)

“…On day 0.5 post coitus (pc), the number of uterine CD11c⁺CD103^–MHC classII^highCD86^high–mature DCs rapidly increased and then decreased to non-pregnancy levels on days 1.5 and 2.5 pc. …”

Image_2_Development, RSM-based modeling, and process optimization of an ultrasonic coating system for extending the storage life of fresh fruits.JPEG by Maged Mohammed (11005315)

“…The optimal optimization outcome with the desirability of 0.90 demonstrated that coating fresh date palm fruits with a gum Arabic concentration of 9.58% at an air flow rate of 1.95 m/s, a height of liquid above the ultrasonic transducer of 0.62 cm, a liquid temperature of 40°C, a drying time of 7.4 min, a drying temperature of 30°C, and a storage temperature of 5°C resulted in extending the shelf life of the stored fruits to 65 days with 3.47 ripening percentage, 7.39 color change, and 4.22% fruit weight loss. …”

Image_4_Development, RSM-based modeling, and process optimization of an ultrasonic coating system for extending the storage life of fresh fruits.JPEG by Maged Mohammed (11005315)

“…The optimal optimization outcome with the desirability of 0.90 demonstrated that coating fresh date palm fruits with a gum Arabic concentration of 9.58% at an air flow rate of 1.95 m/s, a height of liquid above the ultrasonic transducer of 0.62 cm, a liquid temperature of 40°C, a drying time of 7.4 min, a drying temperature of 30°C, and a storage temperature of 5°C resulted in extending the shelf life of the stored fruits to 65 days with 3.47 ripening percentage, 7.39 color change, and 4.22% fruit weight loss. …”