Discovery of Novel 3‑Phenylpiperidine Derivatives Targeting the β‑Catenin/B-Cell Lymphoma 9 Interaction as a Single Agent and in Combination with the Anti-PD‑1 Antibody for the Tre... by Hao Zhang (15339)

“…Among them, compound <b>41</b> showed the best IC₅₀ (0.72 μM) in a competitive fluorescence polarization assay and a <i>K</i>_D value of 0.26 μM for the β-catenin protein. …”

Discovery of Novel 3‑Phenylpiperidine Derivatives Targeting the β‑Catenin/B-Cell Lymphoma 9 Interaction as a Single Agent and in Combination with the Anti-PD‑1 Antibody for the Tre... by Hao Zhang (15339)

“…Among them, compound <b>41</b> showed the best IC₅₀ (0.72 μM) in a competitive fluorescence polarization assay and a <i>K</i>_D value of 0.26 μM for the β-catenin protein. …”

Discovery of Novel 3‑Phenylpiperidine Derivatives Targeting the β‑Catenin/B-Cell Lymphoma 9 Interaction as a Single Agent and in Combination with the Anti-PD‑1 Antibody for the Tre... by Hao Zhang (15339)

“…Among them, compound <b>41</b> showed the best IC₅₀ (0.72 μM) in a competitive fluorescence polarization assay and a <i>K</i>_D value of 0.26 μM for the β-catenin protein. …”

Overexpression of TbIF1 significantly affects the viability of BF and Dk cells due to the dramatic decrease of the Δψ_m when F_oF₁-ATPase is inhibite... by Brian Panicucci (177311)

Knock-out of <i>atp6v1e1b</i> in zebrafish shows an early phenotypic read-out. by Lore Pottie (10994479)

“…Data are expressed as mean ± SD from 5 biological replicates. (C) Band intensities of fluorescence signals of atp6v1e1 and α-tubulin were quantified and normalized to the corresponding WT controls. …”

Body weight and ovarian characteristics following CR in POLG^D257A/257A female mice. by Christine Faraci (5778434)

“…<p><b>A.</b> Body weight was decreased following the onset of CR. …”

The mean annual TSS and TN load and concentration and area normalized (AN) load at the watershed outlet for the BASE20 and future scenarios. AN load includes the contribution of po... by Elly T. Gay (21170097)

Boxplot showing differences in vertebral cross-sectional growth between girls with increased (<i>n</i> = 14) and decreased vertebral body wedging (<i>n</i> = 13); <i>p</i> = 0.001. by Ervin Poorghasamians (3801475)

Effects of NMDA on Sp1 nuclear translocation in A549 cells. by Xiao-Hong Li (286234)

Image 1_HMOS 2’FL and 3FL prevent house dust mite induced proinflammatory cytokine release in vitro and decrease specific IgE production in a murine allergic asthma model.pdf by Marit Zuurveld (14349609)

A375 melanoma cells are more susceptible to increasing concentrations of hydrogen peroxide and cerium oxide nanoparticles. by Claudia von Montfort (256730)

Propofol g_GABAA potentiation enables sustained alpha by changing the balance of excitation and inhibition. by Austin E. Soplata (4676017)

Rapid effects of OXT on change in maternal and non-maternal behavior from habituation to reunion. by Caleigh D. Guoynes (9645338)

Total FAK was unchanged by TREK-1 deficiency, but FAK phosphorylation at Tyr⁹²⁵ residue was increased in TREK-1 deficient cells, while Tyr³⁹⁷ phosphorylation... by Esra Roan (524613)

Developmental outcomes of different feeding treatments. by Noah H. Rose (703745)

HC-070 reduces marble burying behavior. by Stefan Just (4811358)

Image 5_Deciphering the oncogenic network: how C1QTNF1-AS1 modulates osteosarcoma through miR-34a-5p and glycolytic pathways.tif by Yu Zhang (12946)

“…</p>Discussion<p>Our research emphasizes the critical role of C1QTNF1-AS1 in the pathogenesis of osteosarcoma (OS). We discovered that the downregulation of C1QTNF1-AS1 indirectly upregulates the expression of LDHA and PDK3 by suppressing miR-34a-5p, which functions as a regulator of the Warburg effect. …”

Table_5_The Dual Role of AQP4 in Cytotoxic and Vasogenic Edema Following Spinal Cord Contusion and Its Possible Association With Energy Metabolism via COX5A.XLSX by Yuan Huang (79836)

“…Additionally, the methodology of AQP4 lentivirus-mediated RNA interference (AQP4-RNAi) is used to reveal the effect on edema of SCC and the regulating molecular mechanism. Firstly, we observe that the tissue water content increases after SCC and decreases after the peak value of tissue water content at 3 days (P < 0.05) with abundant expression of AQP4 protein locating around vascular endothelial cells (VECs), which suggests that the increasing AQP4 promotes water reabsorption and improves vasogenic edema in the early stage of SCC. …”

Table 5_Deciphering the oncogenic network: how C1QTNF1-AS1 modulates osteosarcoma through miR-34a-5p and glycolytic pathways.doc by Yu Zhang (12946)

“…</p>Discussion<p>Our research emphasizes the critical role of C1QTNF1-AS1 in the pathogenesis of osteosarcoma (OS). We discovered that the downregulation of C1QTNF1-AS1 indirectly upregulates the expression of LDHA and PDK3 by suppressing miR-34a-5p, which functions as a regulator of the Warburg effect. …”

Supplementary Figure 3 - Niraparib treatment increases DNA damage and decreases proliferation. from Poly-ADP-Ribose Polymerase as a Therapeutic Target in Pediatric Diffuse Intrinsi... by Yevgen Chornenkyy (15072472)