Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases by Luping Pang (8268324)

“…<i>In vitro</i> using <i>E. coli</i> serRS and aspRS, the best compounds demonstrated IC₅₀ values in the low nanomolar range, with a clear preference for cytosine or N3-methyluracil over uracil. …”

SWR-associated increase in neuronal firing rates is weakened in APP/PS1 mice in both dCA1 and vCA1. by Udaysankar Chockanathan (18510288)

“…(M) In vCA1, the SWR log₁₀(modulation index) was significantly decreased in APP/PS1 mice relative to C57BL/6 controls (mean ± std: C57BL/6 = 3.50 ± 1.49, APP/PS1 = 2.28 ± 1.70 Hz, p < 10⁻⁶, two-sided Wilcoxon rank-sum test, n_C57BL/6 = 689 neurons, n_APP/PS1 = 651 neurons).…”

During <i>LdCen^-/-</i> ID infection, neutrophil derived increased CCL3 recruits significantly higher number of dendritic cells attributed with proinflammatory phenotype... by Parna Bhattacharya (316881)

Neutrophil depletion abrogates CCL3 generation, DC recruitment in <i>LdCen^-/-</i> infected mice ear dLN: recruited DC’s exhibit anti-inflammatory phenotype. by Parna Bhattacharya (316881)

Higher expression of proinflammatory cytokines, co-stimulatory molecules and subsequent antigen presentation in P1 DCs that have captured <i>LdCen^-/-</i> infected neutro... by Parna Bhattacharya (316881)

Engineering and Functional Expression of the Type III Secretion System in <i>Xenorhabdus</i>: Enhancing Insecticidal Efficacy and Expanding T3SE Libraries by Xiyin Huang (11528200)

“…In <i>Helicoverpa armigera</i> models, the engineered strain induced severe intestinal damage by suppressing antimicrobial peptide expression and demonstrated improved colonization and biocontrol efficacy (LC₅₀ decreased by 3.7-fold). Crucially, the TT01 derived T3SS mediated delivery of XopAa novel effector exhibiting YopJ-family homology and characteristic T3SS effector featuresinto host cells. …”

Engineering and Functional Expression of the Type III Secretion System in <i>Xenorhabdus</i>: Enhancing Insecticidal Efficacy and Expanding T3SE Libraries by Xiyin Huang (11528200)

“…In <i>Helicoverpa armigera</i> models, the engineered strain induced severe intestinal damage by suppressing antimicrobial peptide expression and demonstrated improved colonization and biocontrol efficacy (LC₅₀ decreased by 3.7-fold). Crucially, the TT01 derived T3SS mediated delivery of XopAa novel effector exhibiting YopJ-family homology and characteristic T3SS effector featuresinto host cells. …”

Engineering and Functional Expression of the Type III Secretion System in <i>Xenorhabdus</i>: Enhancing Insecticidal Efficacy and Expanding T3SE Libraries by Xiyin Huang (11528200)

“…In <i>Helicoverpa armigera</i> models, the engineered strain induced severe intestinal damage by suppressing antimicrobial peptide expression and demonstrated improved colonization and biocontrol efficacy (LC₅₀ decreased by 3.7-fold). Crucially, the TT01 derived T3SS mediated delivery of XopAa novel effector exhibiting YopJ-family homology and characteristic T3SS effector featuresinto host cells. …”

Engineering and Functional Expression of the Type III Secretion System in <i>Xenorhabdus</i>: Enhancing Insecticidal Efficacy and Expanding T3SE Libraries by Xiyin Huang (11528200)

“…In <i>Helicoverpa armigera</i> models, the engineered strain induced severe intestinal damage by suppressing antimicrobial peptide expression and demonstrated improved colonization and biocontrol efficacy (LC₅₀ decreased by 3.7-fold). Crucially, the TT01 derived T3SS mediated delivery of XopAa novel effector exhibiting YopJ-family homology and characteristic T3SS effector featuresinto host cells. …”

Engineering and Functional Expression of the Type III Secretion System in <i>Xenorhabdus</i>: Enhancing Insecticidal Efficacy and Expanding T3SE Libraries by Xiyin Huang (11528200)

“…In <i>Helicoverpa armigera</i> models, the engineered strain induced severe intestinal damage by suppressing antimicrobial peptide expression and demonstrated improved colonization and biocontrol efficacy (LC₅₀ decreased by 3.7-fold). Crucially, the TT01 derived T3SS mediated delivery of XopAa novel effector exhibiting YopJ-family homology and characteristic T3SS effector featuresinto host cells. …”

Male flies with a mixed background have not responded to high temperature-mediated body fat loss. by Tucker Hopkins (20790529)

Table_1_Distribution and potential risk factors of bisphenol a in serum and urine among Chinese from 2004 to 2019.docx by Wenjing Zhang (246857)

“…Background<p>Bisphenol A (BPA) is an oil-derived, large-market volume chemical with endocrine disrupting properties and reproductive toxicity. …”

Table_1_Distribution and potential risk factors of bisphenol a in serum and urine among Chinese from 2004 to 2019.docx by Wenjing Zhang (246857)

“…Background<p>Bisphenol A (BPA) is an oil-derived, large-market volume chemical with endocrine disrupting properties and reproductive toxicity. …”

A picture and a diagram of current meter components. by Jacob L. Johansen (104601)

The values for <i>k</i>_cat and <i>K</i>_M are sourced from [19]. by J. Roadnight Sheehan (20141887)

Forecasting severe grape downy mildew attacks using machine learning by Mathilde Chen (8566473)

“…Reducing the number of treatments is a major issue from both an environmental and a public health point of view. …”

Role of NF-E2 related factor 2 (Nrf2) on chemotherapy resistance in acute myeloid leukemia (AML) and the effect of pharmacological inhibition of Nrf2 by Sreeja Karathedath (4025708)

“…Drug resistance and toxic side effects pose a major threat to treatment success and hence alternate less toxic therapies are warranted. …”

Image_5_Requirement of a putative mitochondrial GTPase, GemA, for azole susceptibility, virulence, and cell wall integrity in Aspergillus fumigatus.JPEG by Xiaogang Zhou (3115482)

Supplementary Material for: Structural and functional effects of C5aR1 antagonism in a rat model of neonatal hypoxic-ischemic encephalopathy by Saadat A. (18613231)

“…Reasoning C5aR1 antagonism can decrease excessive neuroinflammation and thereby improve neurological and functional outcomes, we tested this hypothesis in a rat model of HIE with PMX205, a small molecule that inhibits C5a-C5aR1 interaction. …”

Δ<i>ompF</i> has altered doxycycline permeability. by Hector S. Alvarez-Manzo (12551730)