Leveraging Peripheral CB1 Antagonism in 1,4,5,6-Tetrahydropyridazine-Based Amidine Substituted Sulfonyl Analogs for Treating Metabolic Disorders by Pinaki Bhattacharjee (11971366)

“…CB₁ receptor antagonists that are peripherally acting hold promise for treating obesity, diabetes and fibrotic disorders highlighting their importance in treating metabolic syndrome disorders (MetS). We synthesized and evaluated compounds by integrating amidine fragments into 1,4,5,6-tetrahydropyridazine-based sulfonyl urea scaffolds for blocking CB₁ receptors. …”

Table_1_EXOSC5 as a Novel Prognostic Marker Promotes Proliferation of Colorectal Cancer via Activating the ERK and AKT Pathways.DOCX by Hongda Pan (6996182)

“…In this study, we investigated the functions and mechanisms by which EXOSC5 promotes the progression of CRC.…”

Leveraging Peripheral CB1 Antagonism in 1,4,5,6-Tetrahydropyridazine-Based Amidine Substituted Sulfonyl Analogs for Treating Metabolic Disorders by Pinaki Bhattacharjee (11971366)

“…CB₁ receptor antagonists that are peripherally acting hold promise for treating obesity, diabetes and fibrotic disorders highlighting their importance in treating metabolic syndrome disorders (MetS). We synthesized and evaluated compounds by integrating amidine fragments into 1,4,5,6-tetrahydropyridazine-based sulfonyl urea scaffolds for blocking CB₁ receptors. …”

Table_5_Identification, Characterization, and Transcriptional Reprogramming of Epithelial Stem Cells and Intestinal Enteroids in Simian Immunodeficiency Virus Infected Rhesus Macaq... by Nongthombam Boby (4255957)

“…Understanding the molecular mechanisms underlying the disrupted epithelial regeneration might provide an alternative approach for the treatment of HIV-mediated enteropathy and immune activation. We have observed a significant increased presence of α defensin5+ (HD5) Paneth cells and proliferating Ki67+ epithelial cells as well as decreased expression of E-cadherin expression in epithelial cells during SIV infection. …”

Table_2_EXOSC5 as a Novel Prognostic Marker Promotes Proliferation of Colorectal Cancer via Activating the ERK and AKT Pathways.DOCX by Hongda Pan (6996182)

“…In this study, we investigated the functions and mechanisms by which EXOSC5 promotes the progression of CRC.…”

Table_5_FOXO3a Alleviates the Inflammation and Oxidative Stress via Regulating TGF-β and HO-1 in Ankylosing Spondylitis.docx by Shanshan Xu (276428)

Table_1_EXOSC5 as a Novel Prognostic Marker Promotes Proliferation of Colorectal Cancer via Activating the ERK and AKT Pathways.DOCX by Hongda Pan (6996182)

“…In this study, we investigated the functions and mechanisms by which EXOSC5 promotes the progression of CRC.…”

Image_5_GDPLichi: a DNA Damage Repair-Related Gene Classifier for Predicting Lung Adenocarcinoma Immune Checkpoint Inhibitors Response.tif by Yang Leng (1733458)

Nitrogen and phosphorus inputs, outputs (in kg per animal) and nutrient imbalance ratio (NIR) of five background-finishing beef systems of eastern Uruguay by P Modernel (557300)

“…Although it has been used as a sustainability index for assessing production systems, it does not take into account many other biophysical environmental dimensions more relevant at the local scale, such as soil erosion, nutrient imbalance, and pesticide contamination. We estimated carbon footprint, fossil fuel energy use, soil erosion, nutrient imbalance, and risk of pesticide contamination for five real beef background-finishing systems with increasing levels of intensification in Uruguay, which were combinations of grazing rangelands (RL), seeded pastures (SP), and confined in feedlot (FL). …”

image5_Yuan-Hu Zhi Tong Prescription Mitigates Tau Pathology and Alleviates Memory Deficiency in the Preclinical Models of Alzheimer’s Disease.tif by A. Iyaswamy (9583382)

Leveraging Peripheral CB1 Antagonism in 1,4,5,6-Tetrahydropyridazine-Based Amidine Substituted Sulfonyl Analogs for Treating Metabolic Disorders by Pinaki Bhattacharjee (11971366)

“…CB₁ receptor antagonists that are peripherally acting hold promise for treating obesity, diabetes and fibrotic disorders highlighting their importance in treating metabolic syndrome disorders (MetS). We synthesized and evaluated compounds by integrating amidine fragments into 1,4,5,6-tetrahydropyridazine-based sulfonyl urea scaffolds for blocking CB₁ receptors. …”

Image_5_Upregulated IL-6 Indicates a Poor COVID-19 Prognosis: A Call for Tocilizumab and Convalescent Plasma Treatment.TIF by Jian Wu (41301)

“…Two specific treatments, namely, tocilizumab and convalescent plasma therapy (CPT), decreased the level of IL-6 and relieved inflammation. …”

Table_3_EXOSC5 as a Novel Prognostic Marker Promotes Proliferation of Colorectal Cancer via Activating the ERK and AKT Pathways.XLSX by Hongda Pan (6996182)

“…In this study, we investigated the functions and mechanisms by which EXOSC5 promotes the progression of CRC.…”

The 5′ Flanking Region and Intron1 of the Bovine Prion Protein Gene (<em>PRNP</em>) Are Responsible for Negative Feedback Regulation of the Prion Protein by Guangai Xue (179316)

“…Furthermore, deletion mutants derived from the wild-type haplotype showed that nucleotides −315 to +2526, which include the 5′-flanking region and exon1, were essential for the response. …”

Table_2_EXOSC5 as a Novel Prognostic Marker Promotes Proliferation of Colorectal Cancer via Activating the ERK and AKT Pathways.DOCX by Hongda Pan (6996182)

“…In this study, we investigated the functions and mechanisms by which EXOSC5 promotes the progression of CRC.…”

Image_5_RNA 2’-O-Methyltransferase Fibrillarin Facilitates Virus Entry Into Macrophages Through Inhibiting Type I Interferon Response.tif by Panpan Li (484033)

“…Once FBL is down-regulated, the decreased Nm modifications of RNA in macrophages may act as “non-self” RNA and be recognized by RNA sensor interferon induced with helicase C domain 1 (MDA5), leading to innate immune activation by inducing the expression of IFN-I and ISGs. …”

Table_2_TIGIT+Tfh show poor B-helper function and negatively correlate with SARS-CoV-2 antibody titre.xlsx by Natalie M. Edner (18628360)

Table_5_Maternal High-Protein and Low-Protein Diets Perturb Hypothalamus and Liver Transcriptome and Metabolic Homeostasis in Adult Mouse Offspring.XLSX by Lisa J. Martin (228675)

“…The LP/HC diet group also showed reduced birth and weanling weights, whereas the HP/LC offspring displayed increased weanling weight with increased adiposity beyond 5 months of age. Gene expression profiling of hypothalamus and liver revealed alterations in diverse molecular pathways by both diets. …”

Table_3_EXOSC5 as a Novel Prognostic Marker Promotes Proliferation of Colorectal Cancer via Activating the ERK and AKT Pathways.XLSX by Hongda Pan (6996182)

“…In this study, we investigated the functions and mechanisms by which EXOSC5 promotes the progression of CRC.…”

Image_5_GDPLichi: a DNA Damage Repair-Related Gene Classifier for Predicting Lung Adenocarcinoma Immune Checkpoint Inhibitors Response.tif by Yang Leng (1733458)