Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors by Stanislav Andreev (11067165)

“…Here, by addressing a high-energy water, we improved the IC₅₀ value of our co-crystallized glycogen synthase kinase-3β (GSK-3β) inhibitor by nearly two orders of magnitude. …”

Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors by Stanislav Andreev (11067165)

“…Here, by addressing a high-energy water, we improved the IC₅₀ value of our co-crystallized glycogen synthase kinase-3β (GSK-3β) inhibitor by nearly two orders of magnitude. …”

Twenty-two identified and replicated loci and their overlap with associations to metabolic traits and clinical phenotypes. by Johannes Raffler (793347)

“…<p>^a SNP with the strongest association to targeted metabolic traits (“lead SNP”)</p><p>^b SNP with the strongest association to non-targeted metabolic traits</p><p>^c manually added to the list of most plausible candidate genes derived by evidence-based selection</p><p>^d additional candidates match to other non-targeted traits that also associate with the lead SNP</p><p>^e results from GWAS (<i>P</i> < 5.0×10⁻⁸)</p><p>^f mutations determined in clinical studies</p><p>For each locus, we selected all variants that displayed genome-wide significant association signals to metabolic traits in the SHIP-0 cohort. …”

Quantification of enzyme activity for PDH in experimental groups V-TAC versus TMG-TAC. by Wei Zhong Zhu (14014073)

Decreased microglial activation in TREM2-KO mice after stroke. by Matthias W. Sieber (106521)

Calpain protein expression level and enzyme activity are decreased in calpain mutants. by James B. Reinecke (346003)

miR-275 and miR-305 maternal loss-of-function mutants exhibited impaired flight capability, decreased hatching rate and survival rate. by Junfei Xie (3148638)

Bcl6 deficiency decreases expression of lipogenic genes and proteins in liver. by Christopher R. LaPensee (571785)

Maps of median projected λ_<i>S</i> (a) and <i>R</i>₀ (b) across 1st-level sub-national administrative regions in selected South American countries. by Keith Fraser (1868587)

Evaluation of the Acid Baking Technique to Decrease the Phosphorus Content of the Iron Ore by Leonardo Martins da Silva (7425692)

Bradykinin contributes to NE-mediated lung damage and decreased host tolerance. by Manoranjan Sahoo (189969)

Nilotinib decreases the <i>in vitro</i> tumorigenicity of HEI-193 cells. by Nesrin Sabha (127278)

“…*denotes significant value (<i>p</i><0.05). (C) The mean maximal colony diameter was decreased by nilotinib at ≥3 µM in PDGF-BB media, and at ≥5 µM in GM. …”

MS diet decreases production of pro-inflammatory cytokines in stimulated T cells. by Colin Delaney (380939)

Decrease in the number of prescriptions for antibiotics in percentage, by studies assessing this outcome parameter. by Christin Löffler (3539528)

Decreased Rab10 localization in raft fractions following methamphetamine treatment. by Scott M. Vanderwerf (785324)

Reduction of GCC signaling decreases membrane-associated TJPs in IEC monolayer. by Xiaonan Han (231176)

Visual deprivation rescues the decrease in proliferative cells by HDAC1 knockdown. by Yi Tao (178829)

Internet-Delivered Cognitive Behavioral Therapy to Treat Insomnia: A Systematic Review and Meta-Analysis by Michael Seyffert (849995)

“…Internet-delivered cognitive behavioral therapy resulted in a decrease in the insomnia severity index by 4.3 points (95% CI: -7.1, -1.5; p = 0.017) compared to control. …”

SETD2 loss of function in BMSCs showed decreased bone mass. by Lijun Wang (176511)

Erythrocyte membrane beta-actin band decrease intensities in RTT patients. by Alessio Cortelazzo (543292)