Genome-wide screen identifies novel genes required for <i>Borrelia burgdorferi</i> survival in its <i>Ixodes</i> tick vector by James P. Phelan (5856416)

“…Almost half of the genes required for survival in the tick encode proteins of unknown function, while a significant portion (over 20%) encode membrane-associated proteins or lipoproteins. We validated the results of the screen for five Tn mutants by performing individual competition assays using mutant and complemented strains. …”

Impact of Combined mTOR and MEK Inhibition in Uveal Melanoma Is Driven by Tumor Genotype by Alan L. Ho (153035)

“…MAPK activation occurs via somatic mutations in the heterotrimeric G protein subunits <em>GNAQ</em> and <em>GNA11</em> for over 70% of tumors and less frequently via V600E <em>BRAF</em> mutations. In this report, we describe the impact of dual pathway inhibition upon uveal melanoma cell lines with the MEK inhibitor selumetinib (AZD6244/ARRY-142886) and the ATP-competitive mTOR kinase inhibitor AZD8055. …”

Yorkie facilitates cell survival during larval eye development in Drosophila melanogaster by Brooke Allen (8728169)

Whole-Core 3D Multiphysics Transient Modeling of a Prismatic Micro High-Temperature Gas-Cooled Reactor by Marc C. Van Den Berg (21609902)

Study on the efficiency of dsRNAs with increasing length in RNA-based silencing of the <i>Fusarium CYP51</i> genes by L. Höfle (8290848)

Arginine 58 is indispensable for proper function of the <i>Francisella tularensis</i> subsp. <i>holarctica</i> FSC200 HU protein, and its substitution alters virulence and mediates... by Pavla Pavlik (13953195)

Data_Sheet_1_Effect of Land Use History on Biodiversity of Pine Plantations.docx by Sandra V. Uribe (8575152)

Potential Regulatory Role of Human-Carboxylesterase‑1 Glycosylation in Liver Cancer Cell Growth by Keun Na (1666186)

“…We found that the population of <i>CES1</i>-overexpressing (OE) cells decreased and that their doubling time was longer compared with mock control liver cancer cells. …”

Kinematic Profiles of Mudskipper Pectoral Fin versus Salamander Forelimb by Zachary Quigley (11422969)

“…Elbow (C) and wrist (D) angles were set such that a fully extended joint corresponds to 180°, with the angle decreasing as the joint flexed. …”

Image 2_Bacillus Spizizenii FMH45-based biofertilizer enhances growth and halotolerance of cherry tomato plants under hydroponic cultivation systems.tif by Fatma Masmoudi (16819554)

“…Furthermore, HB45-treatment enhanced the plant oxidative stress response as evidenced by stable catalase activity, an approximately 50% reduction in lipid peroxidation markers such as malondialdehyde (MDA), and a 35% decrease in reactive oxygen species (ROS), including hydrogen peroxide (H₂O₂). …”

RyhB binding at Site I and Site II blocks ribosome binding to the <i>msrB</i> translation initiation region. by Julia Bos (411731)

“…<p>(A) An autoradiogram of a toeprint analysis is shown (for details, see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0063647#s2" target="_blank">Materials and Methods</a>, and Results). …”

Data_Sheet_1_Network analysis of live pig movements in North Macedonia: Pathways for disease spread.pdf by Kathleen C. O'Hara (11769671)

“…In 2019, the network demonstrated a marked decrease in betweenness and increase in communities. …”

Table_1_AHLs Regulate Biofilm Formation and Swimming Motility of Hafnia alvei H4.DOCX by Yao lei Zhu (6855239)

“…Furthermore, ΔluxI also exhibited significant (P < 0.05) decrease in the expression of biofilm- and swimming motility-related genes, flgA, motA and cheA, consistent with the results observed for biofilm formation and swimming motility. …”

Regulation of the Inevitable Water-Responsivity of Silk Fibroin Biopolymer by Polar Amino Acid Activation by Woojin Choi (610810)

“…Furthermore, the water dynamics study suggested that active amino acid stabilizes crystallization-triggering water molecules. As a proof-of-concept, we verified that a 30% increase in the activity of serine resulted in a 50% decrease in the crystallization rate. …”

Animals in each vaccine group demonstrate similar plasma viral loads, CD4⁺ T cell counts, and ART responsiveness. by Hillary Claire Tunggal (10987656)

“…The dotted line indicates 50% of baseline CD4⁺ T cells. CD4 T cell counts were obtained using a Beckman Coulter^® AC*T^™ 5diff hematology analyzer. …”

Churchill regulates cell movement and mesoderm specification by repressing Nodal signaling-1 by Eric R Londin (83702)

“…Induction of results in a 50% increase in Sip1 expression, conversely, inhibition of results in a 70% reduction of Sip1 expression. …”

Calpain mediated the cleavage of calcineurin in PAN-treated podocytes. by Fangrui Ding (659863)

“…(C, D) The expression of cleaved 45-kDa calcineurin was dependent on the increased concentration of PAN (25, 50, 75, 100, and 125 μg/ml) in podocytes and was associated with a dose-dependent decrease in 60-kDa calcineurin. …”

Results of SOD knockdown/deletion or overexpression according to the model. by Jan Gruber (170653)

“…This result is independent of the exact choice of parameters when feedback inhibition is considered (n = 1) as previously observed <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0019444#pone.0019444-Gardner2" target="_blank">[50]</a>. …”

Image_1_Verification of autoclaving-cooling treatment to increase the resistant starch contents in food starches based on meta-analysis result.jpg by Didah Nur Faridah (3844126)

“…Verification using corn flour and corn starch showed a significant increase in RS contents from 15.84 to 27.78% and from 15.27 to 32.53%, respectively, and a significant decrease in starch digestibility from 67.02 to 35.74% and from 76.15 to 28.09%, respectively. …”

Doxorubicin-Mediated Bone Loss in Breast Cancer Bone Metastases Is Driven by an Interplay between Oxidative Stress and Induction of TGFβ by Tapasi Rana (339809)

“…Doxorubicin, which is a known inducer of oxidative stress, decreased osteoblast survival and differentiation, which was rescued by N-acetyl cysteine (NAC). …”