TAS2R inhibition of stimulated [Ca²⁺]_i is not dependent on G_i or G_q coupled receptor stimulation. by Blanca Camoretti-Mercado (762326)

Social interaction of <i>Cdkl5</i> -/Y mice is uniquely altered. by Kosuke Okuda (5150393)

“…<p>(A-E) The social interaction test in a novel environment (one-chamber test). <i>Cdkl5</i> -/Y mice show a significant increase in the total duration of contacts (A), a significant increase in the mean duration per contact (B), a significant decrease in the number of contacts (C), a significant decrease in the total duration of active contacts (D), and a significant decrease in the distance traveled (E). …”

Quantitative effect of TAS2R agonists on [Ca²⁺]_i in HASM stimulated by five GPCR agonists. by Blanca Camoretti-Mercado (762326)

Cell proliferation. by Bo Huang (30906)

COVID-19 in Lebanon: The daily number of COVID-19 cases throughout the waves of the pandemic in Lebanon and associated SARS-CoV-2 variants between January 2021 and September 2022. by Rima Moghnieh (679199)

Model food web mean path length and dominant eigenvalue as a function of nominal size and connectance. by Jane Shevtsov (803549)

“…In (a) and (c), mean path length generally decreases with connectance, while the dominant eigenvalue shows a curvilinear pattern. …”

Haematocrit of red cells suspended in 5 different [NaCl] at 25 and 37°C compared to that in the physiological state in which [NaCl] is 148 mM and temperature 37°C (the reference li... by Chadapust J. Sudsiri (14670602)

Sema3a inhibits the differentiation of Raw264.7 cells to osteoclasts under 2Gy radiation by reducing inflammation by Bo Huang (30906)

“…Raw264.7 cells were divided into four groups: A, receiving no radiation; B, receiving no radiation + 50ngng/ml Sema3a; C, receiving 2Gy radiation; and D, receiving 2Gy radiation +50ngng/ml Sema3a. …”

Blocking KDM5B demethylation leads to increased cytokine production and repression of Th2 responses. by Catherine Ptaschinski (756139)

“…<p>Following RSV infection, KDM5B is upregulated through unknown mechanisms. KDM5B demethylates H3K4 at the promoter regions of proinflammatory cytokines, leading to decreased transcription. …”

Targeting Tyrosinase: Development and Structural Insights of Novel Inhibitors Bearing Arylpiperidine and Arylpiperazine Fragments by Stefania Ferro (76724)

“…The crystal structures of TyBm with inhibitor <b>3</b> (IC₅₀ value of 25.11 μM) and <b>16</b> (IC₅₀ value of 5.25 μM) were solved, confirming the binding poses hypothesized by in silico studies and revealing the main molecular determinants for the binding recognition of the inhibitors.…”

Turn-off and turn-on with hard switching at <i>f</i>_<i>r</i><i>/2</i> < <i>f</i>_<i>SL</i>(50 kHz) < <i>f</i>_<i>r</i> of the switch <i>S</i><sub><i>... by M. Zakir Hossain (6033752)

Crystal structures of Triosephosphate Isomerases from <i>Taenia solium</i> and <i>Schistosoma mansoni</i> provide insights for vaccine rationale and drug design against helminth pa... by Pedro Jimenez-Sandoval (831603)

“…This insert is located between α5 and β6 and is proposed to be the main TPI epitope. …”

Diurnal change of retinal vessel density and mean ocular perfusion pressure in patients with open-angle glaucoma by Sung Uk Baek (6640382)

“…</p><p>Methods</p><p>Peripapillary/macular RVD (using swept-source OCTA), intraocular pressure (IOP), and systemic blood pressure (BP) were measured five times a day (8 a.m., 11 a.m., 2 p.m.,5 p.m. and 8 p.m.). …”

Natural Derivatives of Selective HDAC8 Inhibitors with Potent <i>in Vivo</i> Antitumor Efficacy against Breast Cancer by Xiaoming Chen (230202)

“…Upon additional modifications of corallorazine D, a candidate compound <b>5k</b>, demonstrated remarkable inhibitory potency against HDAC8 (IC₅₀ = 0.12 ± 0.01 nM), 89-fold superior to PCI-34051. …”

Natural Derivatives of Selective HDAC8 Inhibitors with Potent <i>in Vivo</i> Antitumor Efficacy against Breast Cancer by Xiaoming Chen (230202)

“…Upon additional modifications of corallorazine D, a candidate compound <b>5k</b>, demonstrated remarkable inhibitory potency against HDAC8 (IC₅₀ = 0.12 ± 0.01 nM), 89-fold superior to PCI-34051. …”

Natural Derivatives of Selective HDAC8 Inhibitors with Potent <i>in Vivo</i> Antitumor Efficacy against Breast Cancer by Xiaoming Chen (230202)

“…Upon additional modifications of corallorazine D, a candidate compound <b>5k</b>, demonstrated remarkable inhibitory potency against HDAC8 (IC₅₀ = 0.12 ± 0.01 nM), 89-fold superior to PCI-34051. …”

Natural Derivatives of Selective HDAC8 Inhibitors with Potent <i>in Vivo</i> Antitumor Efficacy against Breast Cancer by Xiaoming Chen (230202)

“…Upon additional modifications of corallorazine D, a candidate compound <b>5k</b>, demonstrated remarkable inhibitory potency against HDAC8 (IC₅₀ = 0.12 ± 0.01 nM), 89-fold superior to PCI-34051. …”

Natural Derivatives of Selective HDAC8 Inhibitors with Potent <i>in Vivo</i> Antitumor Efficacy against Breast Cancer by Xiaoming Chen (230202)

“…Upon additional modifications of corallorazine D, a candidate compound <b>5k</b>, demonstrated remarkable inhibitory potency against HDAC8 (IC₅₀ = 0.12 ± 0.01 nM), 89-fold superior to PCI-34051. …”

Natural Derivatives of Selective HDAC8 Inhibitors with Potent <i>in Vivo</i> Antitumor Efficacy against Breast Cancer by Xiaoming Chen (230202)

“…Upon additional modifications of corallorazine D, a candidate compound <b>5k</b>, demonstrated remarkable inhibitory potency against HDAC8 (IC₅₀ = 0.12 ± 0.01 nM), 89-fold superior to PCI-34051. …”

Natural Derivatives of Selective HDAC8 Inhibitors with Potent <i>in Vivo</i> Antitumor Efficacy against Breast Cancer by Xiaoming Chen (230202)

“…Upon additional modifications of corallorazine D, a candidate compound <b>5k</b>, demonstrated remarkable inhibitory potency against HDAC8 (IC₅₀ = 0.12 ± 0.01 nM), 89-fold superior to PCI-34051. …”