Nitrogen and phosphorus inputs, outputs (in kg per animal) and nutrient imbalance ratio (NIR) of five background-finishing beef systems of eastern Uruguay by P Modernel (557300)

“…Although it has been used as a sustainability index for assessing production systems, it does not take into account many other biophysical environmental dimensions more relevant at the local scale, such as soil erosion, nutrient imbalance, and pesticide contamination. We estimated carbon footprint, fossil fuel energy use, soil erosion, nutrient imbalance, and risk of pesticide contamination for five real beef background-finishing systems with increasing levels of intensification in Uruguay, which were combinations of grazing rangelands (RL), seeded pastures (SP), and confined in feedlot (FL). …”

image5_Yuan-Hu Zhi Tong Prescription Mitigates Tau Pathology and Alleviates Memory Deficiency in the Preclinical Models of Alzheimer’s Disease.tif by A. Iyaswamy (9583382)

Leveraging Peripheral CB1 Antagonism in 1,4,5,6-Tetrahydropyridazine-Based Amidine Substituted Sulfonyl Analogs for Treating Metabolic Disorders by Pinaki Bhattacharjee (11971366)

“…CB₁ receptor antagonists that are peripherally acting hold promise for treating obesity, diabetes and fibrotic disorders highlighting their importance in treating metabolic syndrome disorders (MetS). We synthesized and evaluated compounds by integrating amidine fragments into 1,4,5,6-tetrahydropyridazine-based sulfonyl urea scaffolds for blocking CB₁ receptors. …”

Image_5_Upregulated IL-6 Indicates a Poor COVID-19 Prognosis: A Call for Tocilizumab and Convalescent Plasma Treatment.TIF by Jian Wu (41301)

“…Two specific treatments, namely, tocilizumab and convalescent plasma therapy (CPT), decreased the level of IL-6 and relieved inflammation. …”

Table_3_EXOSC5 as a Novel Prognostic Marker Promotes Proliferation of Colorectal Cancer via Activating the ERK and AKT Pathways.XLSX by Hongda Pan (6996182)

“…In this study, we investigated the functions and mechanisms by which EXOSC5 promotes the progression of CRC.…”

The 5′ Flanking Region and Intron1 of the Bovine Prion Protein Gene (<em>PRNP</em>) Are Responsible for Negative Feedback Regulation of the Prion Protein by Guangai Xue (179316)

“…Furthermore, deletion mutants derived from the wild-type haplotype showed that nucleotides −315 to +2526, which include the 5′-flanking region and exon1, were essential for the response. …”

Table_2_EXOSC5 as a Novel Prognostic Marker Promotes Proliferation of Colorectal Cancer via Activating the ERK and AKT Pathways.DOCX by Hongda Pan (6996182)

“…In this study, we investigated the functions and mechanisms by which EXOSC5 promotes the progression of CRC.…”

Image_5_RNA 2’-O-Methyltransferase Fibrillarin Facilitates Virus Entry Into Macrophages Through Inhibiting Type I Interferon Response.tif by Panpan Li (484033)

“…Once FBL is down-regulated, the decreased Nm modifications of RNA in macrophages may act as “non-self” RNA and be recognized by RNA sensor interferon induced with helicase C domain 1 (MDA5), leading to innate immune activation by inducing the expression of IFN-I and ISGs. …”

Table_2_TIGIT+Tfh show poor B-helper function and negatively correlate with SARS-CoV-2 antibody titre.xlsx by Natalie M. Edner (18628360)

Table_5_Maternal High-Protein and Low-Protein Diets Perturb Hypothalamus and Liver Transcriptome and Metabolic Homeostasis in Adult Mouse Offspring.XLSX by Lisa J. Martin (228675)

“…The LP/HC diet group also showed reduced birth and weanling weights, whereas the HP/LC offspring displayed increased weanling weight with increased adiposity beyond 5 months of age. Gene expression profiling of hypothalamus and liver revealed alterations in diverse molecular pathways by both diets. …”

Table_3_EXOSC5 as a Novel Prognostic Marker Promotes Proliferation of Colorectal Cancer via Activating the ERK and AKT Pathways.XLSX by Hongda Pan (6996182)

“…In this study, we investigated the functions and mechanisms by which EXOSC5 promotes the progression of CRC.…”

Image_5_GDPLichi: a DNA Damage Repair-Related Gene Classifier for Predicting Lung Adenocarcinoma Immune Checkpoint Inhibitors Response.tif by Yang Leng (1733458)

Image 5_Isolation and identification of Alternaria alstroemeriae causing postharvest black rot in citrus and its control using curcumin-loaded nanoliposomes.jpeg by Jie Li (15030)

Table_3_EXOSC5 as a Novel Prognostic Marker Promotes Proliferation of Colorectal Cancer via Activating the ERK and AKT Pathways.XLSX by Hongda Pan (6996182)

“…In this study, we investigated the functions and mechanisms by which EXOSC5 promotes the progression of CRC.…”

Data Sheet 5_Identification of mitochondria-related feature genes for predicting type 2 diabetes mellitus using machine learning methods.csv by Xiuping Xuan (8686266)

“…Additionally, drugs prediction analysis revealed 2(S)-amino-6-boronohexanoic acid, difluoromethylornithine, and compound 9 could target ARG2, while metformin was a candidate drug for SCL2A2. Finally, all five genes were confirmed to be decreased in MIN6 cells treated with high glucose and palmitic acid.…”

Image_5_Rapamycin Nano-Micelle Ophthalmic Solution Reduces Corneal Allograft Rejection by Potentiating Myeloid-Derived Suppressor Cells' Function.TIF by Chao Wei (327736)

Table_2_EXOSC5 as a Novel Prognostic Marker Promotes Proliferation of Colorectal Cancer via Activating the ERK and AKT Pathways.DOCX by Hongda Pan (6996182)

“…In this study, we investigated the functions and mechanisms by which EXOSC5 promotes the progression of CRC.…”

Presentation_1_Risk of severe COVID-19 infection in persons with diabetes during the first and second waves in Denmark: A nationwide cohort study.pdf by Jacob V. Stidsen (8560017)

“…However, when mortality was restricted to the hospitalized population, the crude mortality fell from 26.8% to 19.6% in persons with diabetes, while only a minor decrease was seen in persons without diabetes (from 16.7% to 15.5%).…”

Data_Sheet_1_Development of the Inactivated QazCovid-in Vaccine: Protective Efficacy of the Vaccine in Syrian Hamsters.docx by Kuandyk Zhugunissov (9904219)

“…Further, no replicative virus was isolated from the lungs of vaccinated animals. However, a virulent virus was isolated from the lungs of unvaccinated animals at relatively high titers, reaching 4.5 ± 0.7 log TCID₅₀/mL. …”

Ubr3 regulates the ubiquitination of Cos2. by Tongchao Li (115391)

“…Following immunoprecipitation and Western blot analysis with anti-HA (upper panel), we found that Cos2 is ubiquitinated, as indicated by the smeary shift of the protein (lane 1). …”