Mitochondrial respiration of HL-1 cells exposed for 12 or 72h to LG, NG, HG or IHG. by Patrick Mordel (17020879)

Measurement of ATP production in HL-1 cells exposed for 12 or 72h to LG, NG, HG or IHG. by Patrick Mordel (17020879)

Dietary Restriction Induces Gluconeogenic Gene <i>pck-2</i> Expression via DAF-16, and <i>pck-2</i> Expression is Needed for DR-associated Healthspan Benefits. by Brian Onken (86790)

“…<p>(A) Representative wild-type animals expressing a GFP transcriptional reporter for <i>pck-2</i> (<i>pck-2</i> promoter GFP fusion, lacking <i>pck-2</i> coding sequences) under <i>ad libitum</i> (AL) or dietary restricted (DR) conditions, day 4 of life. …”

The <i>TgCRT</i>-deficient parasites displayed a swollen vacuole and a disrupted endolysosomal system. by L. Brock Thornton (6808385)

“…The TgCPL staining was used to assess the morphology of the VAC. The mean VAC size ± standard error of mean (SEM) was calculated for three independent measurements and is listed in the figure. …”

Column charts of SI_8min and SI_10min in the therapy and control group at follow-up. by Felix L. Herr (21544362)

Column charts of WiAUC in therapy and control group at baseline and follow-up. by Felix L. Herr (21544362)

Functional and structural polarization of human breast epithelial cell organoids grown at 21% and 1% oxygen illustrated by the marker of breast epithelial differentiation and polar... by Marica Vaapil (132671)

“…HMFG/MUC1 displayed a decrease in polarized localization in both primary breast epithelial and MCF-10A cells at hypoxia (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0046543#pone-0046543-g005" target="_blank">Fig. 5</a>A, B). …”

Fluorescence detection of cellular toxicity as a function of starvation or treatment with the mTOR inhibitor, XL-765. by Kara R. Vogel (739629)

The perimeter of L2 cell dendritic trees after silencing <i>Tor</i>, <i>Atg5</i> and <i>Atg7</i> genes. by Ewelina Kijak (3746299)

“…<p>After silencing the <i>Tor</i> (A) or <i>Atg5</i> (B) under control of the 21D-promoter, the daily rhythm of the L2 cell dendritic tree size was abolished (mean +/- SD) [<i>Tor</i>: ANOVA, p>0.05; <i>Atg5</i>: Kruskal-Wallis Test: H (3, N = 401) = 7,722824 p =, 0521], while in case of <i>Atg7</i> (C), the pattern of the daily rhythm of the L2 dendritic trees was changed. …”

Excess glucose availability negatively impacts healthspan of young and old animals; conversely, the benefits of disrupting glycolysis do not include extended maximal lifespan. by Brian Onken (86790)

“…Exposure to excess glucose results in significant decreases in swimming rates in young animals (day 5 from hatching; <i>P</i> = 0.0004, unpaired t test). n = 40 animals per condition from a single trial; error bars represent SEM; *** <i>P</i> < 0.001. …”

Comparison of oxidized proteins extracted from HL-1 cells exposed to LG, NG, HG and IHG between short- (12h) and long-time (72h) glucose treatment. by Patrick Mordel (17020879)

PDRN upregulates SIRT1 protein expression in HaCaT cells exposed to UVB or H₂O₂. by Jingjing Chen (293564)

Autophagic homeostasis is required for the pluripotency of cancer stem cells by Tanveer Sharif (329961)

“…In this report, using both human and murine models of CSCs, we demonstrate that basal levels of autophagy are required to maintain the pluripotency of CSCs, and that this process is differentially regulated by the rate-limiting enzyme in the NAD⁺ synthesis pathway NAMPT (nicotinamide phosphoribosyltransferase) and the transcription factor POU5F1/OCT4 (POU class 5 homeobox 1). …”

Data_Sheet_1_SIRT7-Induced PHF5A Decrotonylation Regulates Aging Progress Through Alternative Splicing-Mediated Downregulation of CDK2.DOCX by Ai Qing Yu (9774356)

“…Specifically, among the identified proteins, we found SIRT7 decrotonylated PHF5A, an alternative splicing (AS) factor, at K25. …”

Data_Sheet_2_SIRT7-Induced PHF5A Decrotonylation Regulates Aging Progress Through Alternative Splicing-Mediated Downregulation of CDK2.XLS by Ai Qing Yu (9774356)

“…Specifically, among the identified proteins, we found SIRT7 decrotonylated PHF5A, an alternative splicing (AS) factor, at K25. …”

Data_Sheet_3_SIRT7-Induced PHF5A Decrotonylation Regulates Aging Progress Through Alternative Splicing-Mediated Downregulation of CDK2.XLSX by Ai Qing Yu (9774356)

“…Specifically, among the identified proteins, we found SIRT7 decrotonylated PHF5A, an alternative splicing (AS) factor, at K25. …”

Birds invest wingbeats to keep a steady head and reap the ultimate benefits of flying together by Lucy A. Taylor (492318)

“…Despite this, no studies have quantified the biomechanical consequences of flying in a cluster flock or pair relative to flying solo. Here, we compared the flight characteristics of homing pigeons (<i>Columba livia</i>) flying solo and in pairs released from a site 7 km from home, using high-precision 5 Hz global positioning system (GPS) and 200 Hz tri-axial accelerometer bio-loggers. …”

Gender and age-specific aspects of awareness and knowledge in basic life support by Mario Krammel (5374268)

“…Interestingly, we observed a strongly decreasing level of knowledge and willingness for BLS attempts (-14%; OR: 0.72 [95%CI: 0.57–0.92]; p = 0.027) and AED-use (-19%; OR: 0.68 [95%CI: 0.54–0.85]; p = 0.001) with increasing age.…”

Development of Prolinol Containing Inhibitors of Hypoxanthine–Guanine–Xanthine Phosphoribosyltransferase: Rational Structure-Based Drug Design by Dianne T. Keough (4660351)

“…Against <i>TBr</i> in cell culture, a prodrug exhibited an EC₅₀ of 10 μM. …”

The KOR antagonist BTRX-335140 blocks U-69,593 responses in mPFC-projecting VTA dopamine neurons. by Elyssa B. Margolis (7933838)