Showing 28,701 - 28,720 results of 49,070 for search '(( 5 ((we decrease) OR (mean decrease)) ) OR ( 50 ((ns decrease) OR (a decrease)) ))', query time: 0.79s Refine Results
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    An activator of G protein-coupled receptor and MEK1/2-ERK1/2 signaling inhibits HIV-1 replication by altering viral RNA processing by Raymond W. Wong (8463498)

    Published 2020
    “…<div><p>The ability of HIV-1 to evolve resistance to combined antiretroviral therapies (cARTs) has stimulated research into alternative means of controlling this infection. We assayed >60 modulators of RNA alternative splicing (AS) to identify new inhibitors of HIV-1 RNA processing—a segment of the viral lifecycle not targeted by current drugs—and discovered compound N-[4-chloro-3-(trifluoromethyl)phenyl]-7-nitro-2,1,3-benzoxadiazol-4-amine (5342191) as a potent inhibitor of both wild-type (<i>Ba-L</i>, <i>NL4-3</i>, <i>LAI</i>, <i>IIIB</i>, and <i>N54</i>) and drug-resistant strains of HIV-1 (IC<sub>50</sub>: ~700 nM) with no significant effect on cell viability at doses tested. 5342191 blocks expression of four essential HIV-1 structural and regulatory proteins (Gag, Env, Tat, and Rev) without affecting total protein synthesis of the cell. …”
  14. 28714

    Value-complexity curve. by Nadav Amir (9761770)

    Published 2020
    “…Complexity tended to be lower for the mutant (heterozygous) animals compared to the wildtypes (warm and cool color scales respectively), and more so for females (circles) than for males (squares). While mean value tended to increased monotonically with training for both mutant and wildtype females (warm and cool gradient lines respectively), the mean complexity of wildtype females exhibited a non-monotonic profile, increasing on days 1-3 and decreasing on day 4. …”
  15. 28715

    Table_1_Diagnostic model for predicting hyperuricemia based on alterations of the gut microbiome in individuals with different serum uric acid levels.pdf by Meiting Liang (5791553)

    Published 2022
    “…</p>Methods<p>We sequenced the V3-V4 variable region of the 16S rDNA gene in 168 fecal samples from HUA patients (n=50), LSU patients (n=61), and controls (n=57). …”
  16. 28716

    Supplementary Materials for 'Association between gastric rhythm and gastroesophageal reflux defined by simultaneous body surface gastric mapping and 24-hour pH testing' by William Xu (22345150)

    Published 2025
    “…Forty subjects were recruited (mean age 46.5 years, 60% female): 20 undergoing pH testing (12 with GERD and 8 symptomatic patients without), and 20 controls. …”
  17. 28717

    DataSheet1_Pooled-analysis of tadalafil and tamsulosin for ureteral calculi.docx by Fengze Sun (12259154)

    Published 2024
    “…But patients receiving 5 mg tadalafil decreased analgesia usage [MD = 101.04, 95% CI (67.56, 134.01), p < 0.00001].…”
  18. 28718

    Case Fatality of Patients with Type 1 Diabetes after Myocardial Infarction by Anne M Kerola (12447754)

    Published 2022
    “…</p> <p><strong>Research design and methods:</strong> Consecutive MI patients with type 1 diabetes (n=1,935; 41% female, mean age: 62.5 years) and without diabetes (n=74,671) admitted to 20 hospitals in Finland from 2005–2018 were studied using national registries. …”
  19. 28719

    Effect of polymer composition. by Yi Bao (278186)

    Published 2022
    “…Data are presented as mean ± SEM; N > 3. We examined the effect of polymer composition on NPs using acetonitrile to dissolve different mass ratios of PLGA(M) with PEG-PLGA at 5 mg/mL concentration, TFR = 300 μL/min, and FRR = 5. …”
  20. 28720

    Table_1_Training-Induced Muscle Adaptations During Competitive Preparation in Elite Female Rowers.docx by Stephan van der Zwaard (3122055)

    Published 2021
    “…Rowing ergometer power output improved during general preparation [+2 ± 2%, effect size (ES) = 0.22, P = 0.004], while fascicle length decreased (−5 ± 8%, ES = −0.47, P = 0.020). Rowing power output further improved during competitive preparation (+5 ± 3%, ES = 0.52, P = 0.010). …”