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we decrease » _ decrease (Expand Search), nn decrease (Expand Search), teer decrease (Expand Search)
ns decrease » nn decrease (Expand Search), _ decrease (Expand Search), use decreased (Expand Search)
a decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
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An activator of G protein-coupled receptor and MEK1/2-ERK1/2 signaling inhibits HIV-1 replication by altering viral RNA processing
Published 2020“…<div><p>The ability of HIV-1 to evolve resistance to combined antiretroviral therapies (cARTs) has stimulated research into alternative means of controlling this infection. We assayed >60 modulators of RNA alternative splicing (AS) to identify new inhibitors of HIV-1 RNA processing—a segment of the viral lifecycle not targeted by current drugs—and discovered compound N-[4-chloro-3-(trifluoromethyl)phenyl]-7-nitro-2,1,3-benzoxadiazol-4-amine (5342191) as a potent inhibitor of both wild-type (<i>Ba-L</i>, <i>NL4-3</i>, <i>LAI</i>, <i>IIIB</i>, and <i>N54</i>) and drug-resistant strains of HIV-1 (IC<sub>50</sub>: ~700 nM) with no significant effect on cell viability at doses tested. 5342191 blocks expression of four essential HIV-1 structural and regulatory proteins (Gag, Env, Tat, and Rev) without affecting total protein synthesis of the cell. …”
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28714
Value-complexity curve.
Published 2020“…Complexity tended to be lower for the mutant (heterozygous) animals compared to the wildtypes (warm and cool color scales respectively), and more so for females (circles) than for males (squares). While mean value tended to increased monotonically with training for both mutant and wildtype females (warm and cool gradient lines respectively), the mean complexity of wildtype females exhibited a non-monotonic profile, increasing on days 1-3 and decreasing on day 4. …”
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28715
Table_1_Diagnostic model for predicting hyperuricemia based on alterations of the gut microbiome in individuals with different serum uric acid levels.pdf
Published 2022“…</p>Methods<p>We sequenced the V3-V4 variable region of the 16S rDNA gene in 168 fecal samples from HUA patients (n=50), LSU patients (n=61), and controls (n=57). …”
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28716
Supplementary Materials for 'Association between gastric rhythm and gastroesophageal reflux defined by simultaneous body surface gastric mapping and 24-hour pH testing'
Published 2025“…Forty subjects were recruited (mean age 46.5 years, 60% female): 20 undergoing pH testing (12 with GERD and 8 symptomatic patients without), and 20 controls. …”
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28717
DataSheet1_Pooled-analysis of tadalafil and tamsulosin for ureteral calculi.docx
Published 2024“…But patients receiving 5 mg tadalafil decreased analgesia usage [MD = 101.04, 95% CI (67.56, 134.01), p < 0.00001].…”
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28718
Case Fatality of Patients with Type 1 Diabetes after Myocardial Infarction
Published 2022“…</p> <p><strong>Research design and methods:</strong> Consecutive MI patients with type 1 diabetes (n=1,935; 41% female, mean age: 62.5 years) and without diabetes (n=74,671) admitted to 20 hospitals in Finland from 2005–2018 were studied using national registries. …”
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28719
Effect of polymer composition.
Published 2022“…Data are presented as mean ± SEM; N > 3. We examined the effect of polymer composition on NPs using acetonitrile to dissolve different mass ratios of PLGA(M) with PEG-PLGA at 5 mg/mL concentration, TFR = 300 μL/min, and FRR = 5. …”
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28720
Table_1_Training-Induced Muscle Adaptations During Competitive Preparation in Elite Female Rowers.docx
Published 2021“…Rowing ergometer power output improved during general preparation [+2 ± 2%, effect size (ES) = 0.22, P = 0.004], while fascicle length decreased (−5 ± 8%, ES = −0.47, P = 0.020). Rowing power output further improved during competitive preparation (+5 ± 3%, ES = 0.52, P = 0.010). …”