Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Sensitivity of SbV-resistant <i>L. panamensis</i> parasites to edelfosine. by Rubén E. Varela-M (326741)

“…<p>(A) Two groups of eight golden hamsters each were infected in the nose with wild type and SbV-resistant <i>L. panamensis</i> (<i>Lp</i>) promastigotes, and after the sixth week post-infection, they were treated with a daily intramuscular injection of Glucantime (SbV) for 4 weeks. …”

The mean annual TSS and TN load and concentration and area normalized (AN) load at the watershed outlet for the BASE20 and future scenarios. AN load includes the contribution of po... by Elly T. Gay (21170097)

Total FAK was unchanged by TREK-1 deficiency, but FAK phosphorylation at Tyr⁹²⁵ residue was increased in TREK-1 deficient cells, while Tyr³⁹⁷ phosphorylation... by Esra Roan (524613)

Number of samples per site during the study period. by Winnie Okore (14139712)

Performance of selected drugs against field isolates during the study period. by Winnie Okore (14139712)

<i>In vitro</i> susceptibility responses of field isolates to antimalarials during the study period. by Winnie Okore (14139712)

<i>Pfmrp1</i> gene SNPs data during the study period. by Winnie Okore (14139712)

Frequency of SNPs in <i>Pfmrp1</i> gene in field isolates during the study period. by Winnie Okore (14139712)

<i>In vitro</i> 95% CI lower and upper mean susceptibility responses of field isolates to antimalarials. by Winnie Okore (14139712)

HC-070 reduces marble burying behavior. by Stefan Just (4811358)

Supplementary Figure 3 - Niraparib treatment increases DNA damage and decreases proliferation. from Poly-ADP-Ribose Polymerase as a Therapeutic Target in Pediatric Diffuse Intrinsi... by Yevgen Chornenkyy (15072472)

Osteocyte-rich cell fractions isolated from <i>Hyp</i> femurs show increased mRNA expression of PPi-regulating genes and decreased mRNA expression of <i>Tnap</i> ex vivo. by Sathish K. Murali (2585914)

Propofol PAC regimes can be modeled as SWO connections between different g_H-background excitation planes. by Austin E. Soplata (4676017)

A pulse of TNF-alpha halts the growth of <i>L</i>. <i>intracellularis</i> in-vitro. by Huan W. Yang (19746645)

Rapid effects of OXT on change in maternal and non-maternal behavior from habituation to reunion. by Caleigh D. Guoynes (9645338)

Deseasonalized anomaly time series of temperature ((a), (b)) and precipitation minus evaporation (<em>P</em> − <em>E</em>) changes over the tropical oceans and the tropical land fo... by Chunlei Liu (57542)

“…Anomalies are calculated with respect to the 1860–1950 period for CMIP5 historical data, 1961–1990 for HadCRUT4 and 1988–2005 for AMIP5 data sets; HadCRUT4 and AMIP anomalies are adjusted to agree with the CMIP5 ensemble mean over the period 1988–2005. …”

Gastrocnemius specific tension recovery 14 days post-reperfusion after saline injection or the delivery of 2x10⁶ <i>in vitro</i> polarized macrophages 24 h after TK-I/R... by Viktoriya Rybalko (840821)

Discovery of Novel 3‑Phenylpiperidine Derivatives Targeting the β‑Catenin/B-Cell Lymphoma 9 Interaction as a Single Agent and in Combination with the Anti-PD‑1 Antibody for the Tre... by Hao Zhang (15339)

“…Among them, compound <b>41</b> showed the best IC₅₀ (0.72 μM) in a competitive fluorescence polarization assay and a <i>K</i>_D value of 0.26 μM for the β-catenin protein. …”

Discovery of Novel 3‑Phenylpiperidine Derivatives Targeting the β‑Catenin/B-Cell Lymphoma 9 Interaction as a Single Agent and in Combination with the Anti-PD‑1 Antibody for the Tre... by Hao Zhang (15339)

“…Among them, compound <b>41</b> showed the best IC₅₀ (0.72 μM) in a competitive fluorescence polarization assay and a <i>K</i>_D value of 0.26 μM for the β-catenin protein. …”