Evolution from a single 20-year model simulation of a 5-year cycling strategy with DHA-PPQ used in the first five years, ASAQ in the following five years, AL during years 10-15, an... by Kien Trung Tran (12035464)

Disrupting Glycolysis-promoting Genes Extends <i>C</i>. <i>elegans</i> Healthspan, Whereas High Glucose and Gluconeogenic Gene Disruptions Shorten Healthspan. by Brian Onken (86790)

“…Trials with 5 and 13 day old animals also showed impaired older age locomotion in 4% glucose (Supplemental <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1008982#pgen.1008982.s002" target="_blank">S1A and S1B Fig</a>). …”

(a) Data Acquisition System (b) Real time data collection. by Shaheer Ahmed Khan (17797647)

Key safety measures including adverse events. by Anuja Dokras (8679261)

“…A total of 169 participants (70.4%) completed the trial between January 2018 and June 2023 (mean age: 29.5 years; mean BMI: 35.6 kg/m²; 70% were White and 23% were Black). …”

Supplementary Figures 1-8 from Targeting Notch Signaling with a Notch2/Notch3 Antagonist (Tarextumab) Inhibits Tumor Growth and Decreases Tumor-Initiating Cell Frequency by Wan-Ching Yen (11520727)

Mice carrying 100P mutations show region-specific decreases in proportions of PV-expressing cells. by Malgorzata Borkowska (3166719)

“…<p>(<b>A</b>) Significant decreases in the proportions of PV+ cells were observed in fSSp, SSp, vAud and in Vis, but not MPFC. …”

Hypoxia stress exerts responses involving the HPA and HPT axes. by Jingqun Ao (381882)

The ORF7a protein of SARS-CoV-2 initiates autophagy and limits autophagosome-lysosome fusion via degradation of SNAP29 to promote virus replication by Peili Hou (4737219)

“…In this study, we demonstrate that overexpression of the SARS-CoV-2 ORF7a protein activates LC3-II and leads to the accumulation of autophagosomes in multiple cell lines, while knockdown of the viral <i>ORF7a</i> gene via shRNAs targeting <i>ORF7a</i> sgRNA during SARS-CoV-2 infection decreased autophagy levels. …”

Transgenerational alteration and inheritance of DNA methylation patterns in 20 randomly chosen S1 plants derived from a Hg²⁺(50 µm)-stressed S0 individual. by Xiufang Ou (136093)

Effect of 2%, 4%, and 6% HQ cream on hippocampal 5-HT level and 5-HT_{1A /1B} receptor expression. by Huali Wu (349567)

“…<p>(A) HQ decreases hippocampus 5-HT level in a dose-dependent manner. …”

Food Polyphenols Fail to Cause a Biologically Relevant Reduction of COX-2 Activity by Ina Willenberg (803704)

“…<div><p>Epidemiologic studies show a correlation between the dietary intake of food polyphenols and beneficial health effects. …”

Complete blood count (CBC) values of dog samples. by Chanon Fa-ngoen (18121319)

“…No significant difference in seroprevalence for the three serogroups was observed in any of the 64 districts sampled. The mean hematocrit level significantly decreased in seropositive dogs (P<0.05). …”

Complete blood count (CBC) values of cat samples. by Chanon Fa-ngoen (18121319)

“…No significant difference in seroprevalence for the three serogroups was observed in any of the 64 districts sampled. The mean hematocrit level significantly decreased in seropositive dogs (P<0.05). …”

AS transcription represses the <i>PHO5</i> gene <i>in cis</i>. by Ana Novačić (8373573)

Protein Tyrosine Phosphatase Oligomerization Studied by a Combination of ¹⁵N NMR Relaxation and ¹²⁹Xe NMR. Effect of Buffer Containing Arginine and Glutamic A... by Jascha Blobel (2383873)

“…They have been applied to study the oligomerization equilibrium of a low-molecular-weight protein tyrosine phosphatase in the presence of 50 mM arginine and 50 mM glutamic acid. …”

Protein Tyrosine Phosphatase Oligomerization Studied by a Combination of ¹⁵N NMR Relaxation and ¹²⁹Xe NMR. Effect of Buffer Containing Arginine and Glutamic A... by Jascha Blobel (2383873)

“…They have been applied to study the oligomerization equilibrium of a low-molecular-weight protein tyrosine phosphatase in the presence of 50 mM arginine and 50 mM glutamic acid. …”

Calcineurin acts as a Ca²⁺ sensor for metamodulation of LP I_h in 5nM DA. by Wulf-Dieter C. Krenz (693267)

“…Black asterisks indicate that a one-way ANOVA on the four DA-treatment groups with Tukey’s post hoc tests that made all pair wise comparisons showed that the decrease observed for the TTX + DA + (+50 OSC) treatment group was significantly different from the other three DA treatment groups, and that those three DA treatment groups [(TTX+DA, TTX+DA+FK506, TTX+DA+FK506+(+50 OSC)] were not significantly different from one another: (F (3,26) = 11.08; p = 0.0001). …”

DataSheet_2_A cyclic peptide-based PROTAC induces intracellular degradation of palmitoyltransferase and potently decreases PD-L1 expression in human cervical cancer cells.docx by Yu-Ying Shi (15975992)

“…Introduction<p>Our previous research has found that degradation of palmitoyltransferase in tumor cells using a linear peptide PROTAC leads to a significant decrease in PD-L1 expression in tumors. …”

DataSheet_1_A cyclic peptide-based PROTAC induces intracellular degradation of palmitoyltransferase and potently decreases PD-L1 expression in human cervical cancer cells.docx by Yu-Ying Shi (15975992)

“…Introduction<p>Our previous research has found that degradation of palmitoyltransferase in tumor cells using a linear peptide PROTAC leads to a significant decrease in PD-L1 expression in tumors. …”

Decreasing rates of disorganised attachment in infants and young children, who are at risk of developing, or who already have disorganised attachment. A systematic review and meta-... by Barry Wright (313307)