Image 6_Behavioral and biochemical changes associated with the analgesic effects of (2R,6R)-hydroxynorketamine alone and in combination with meloxicam following disk puncture in mi... by Vaskar Das (21529538)

“…EC₅₀ estimates for (2R,6R)-Hydroxynorketamine were 14.2 mg/kg (95% CI: 10.3 mg/kg to 19.7 mg/kg) in male and 16.9 mg/kg (95% CI: 12.8 mg/kg to 22.3 mg/kg) in female mice (P < 0.637). (2R,6R)-Hydroxynorketamine plus meloxicam enhanced the analgesic effect on the AUC_0−3d of meloxicam alone. (2R,6R)-Hydroxynorketamine analgesia was associated with increases in Glutamate receptor A1 & A2, p-Kv2.1, p-CaMKII and reduced BDNF protein ratios in the hippocampus, attenuated c-Fos in the spinal cord, and decreased BDNF at the dorsal root ganglion (DRG).…”

Image 5_Behavioral and biochemical changes associated with the analgesic effects of (2R,6R)-hydroxynorketamine alone and in combination with meloxicam following disk puncture in mi... by Vaskar Das (21529538)

“…EC₅₀ estimates for (2R,6R)-Hydroxynorketamine were 14.2 mg/kg (95% CI: 10.3 mg/kg to 19.7 mg/kg) in male and 16.9 mg/kg (95% CI: 12.8 mg/kg to 22.3 mg/kg) in female mice (P < 0.637). (2R,6R)-Hydroxynorketamine plus meloxicam enhanced the analgesic effect on the AUC_0−3d of meloxicam alone. (2R,6R)-Hydroxynorketamine analgesia was associated with increases in Glutamate receptor A1 & A2, p-Kv2.1, p-CaMKII and reduced BDNF protein ratios in the hippocampus, attenuated c-Fos in the spinal cord, and decreased BDNF at the dorsal root ganglion (DRG).…”

Data Sheet 1_Behavioral and biochemical changes associated with the analgesic effects of (2R,6R)-hydroxynorketamine alone and in combination with meloxicam following disk puncture... by Vaskar Das (21529538)

“…EC₅₀ estimates for (2R,6R)-Hydroxynorketamine were 14.2 mg/kg (95% CI: 10.3 mg/kg to 19.7 mg/kg) in male and 16.9 mg/kg (95% CI: 12.8 mg/kg to 22.3 mg/kg) in female mice (P < 0.637). (2R,6R)-Hydroxynorketamine plus meloxicam enhanced the analgesic effect on the AUC_0−3d of meloxicam alone. (2R,6R)-Hydroxynorketamine analgesia was associated with increases in Glutamate receptor A1 & A2, p-Kv2.1, p-CaMKII and reduced BDNF protein ratios in the hippocampus, attenuated c-Fos in the spinal cord, and decreased BDNF at the dorsal root ganglion (DRG).…”

Data Sheet 4_Behavioral and biochemical changes associated with the analgesic effects of (2R,6R)-hydroxynorketamine alone and in combination with meloxicam following disk puncture... by Vaskar Das (21529538)

“…EC₅₀ estimates for (2R,6R)-Hydroxynorketamine were 14.2 mg/kg (95% CI: 10.3 mg/kg to 19.7 mg/kg) in male and 16.9 mg/kg (95% CI: 12.8 mg/kg to 22.3 mg/kg) in female mice (P < 0.637). (2R,6R)-Hydroxynorketamine plus meloxicam enhanced the analgesic effect on the AUC_0−3d of meloxicam alone. (2R,6R)-Hydroxynorketamine analgesia was associated with increases in Glutamate receptor A1 & A2, p-Kv2.1, p-CaMKII and reduced BDNF protein ratios in the hippocampus, attenuated c-Fos in the spinal cord, and decreased BDNF at the dorsal root ganglion (DRG).…”

SAUR63 interactions with PP2C.D proteins. by Punita Nagpal (185838)

HNSCC cell lines (FaDu and Hep2) were treated with DSF at the indicated concentrations (0.5–5 μM) and cell viability was measured by CCK-8 assay. by Young Min Park (101809)

“…<p>A) Degradation of cell viability by DSF was found to be dependent on copper. B) A marked decrease in viability mediated by DSF was noted at 1 μg/mL concentration in FaDu cells and at 0.5 μg/mL in Hep2 cells. …”

Determination of the order of intron removal in the region between exons 5 and 9 on partially spliced <i>COL5A1</i> pre-mRNA (cDNA). by Sofie Symoens (221443)

“…<p>Nuclear RNA was isolated from cultured fibroblasts after incubation with Actinomycine D (ActD) for 0, 5, 10, 20, 40 and 60 min to stop transcription. …”

Effects of RSV on liver weight, liver index and histological changes in HFD rats. by Hui Yang (91136)

Ba₂NaClP₂O₇: Unprecedented Phase Matchability Induced by Symmetry Breaking and Its Unique Fresnoite-Type Structure by Jie Chen (5892)

“…Especially, the relationship between the macrophase matchability and microstructure has been less investigated. Herein, we report a unique Ba₂NaClP₂O₇ representing the first phase-matchable example of the fresnoite family, which exhibits excellent NLO properties, including short absorption edge (<176 nm, ca. 7.0 eV), strong second-harmonic generations at the incident lasers of 850–1110 nm (obv. 0.9–1.3 × KDP; cal. …”

Image_5_The CAGE–MiR-181b-5p–S1PR1 Axis Regulates Anticancer Drug Resistance and Autophagy in Gastric Cancer Cells.TIF by Minjeong Yeon (6064790)

“…MiR-302b-5p regulated autophagic flux and the response to anticancer drugs. …”

Gating properties of <i>CACNA1I</i> variants with pooled WT data. by Yousra El Ghaleb (22075892)

QS signaling over <i>V. cholerae</i> biofilm development. by Grace E. Johnson (21376787)

“…We note that while <i>z-</i>dependent differences in <i>hapR</i> signal are observed here, given that the <i>hapR</i> signal decreases by less than 2-fold from the surface to <i>z</i> locations far from the surface and no such pattern exists according to other spatial analyses (panels <b>C</b>, <b>D</b>, <b>F</b>), the differences likely stem from experiment-to-experiment variations in imaging biases that are not fully corrected by our spatial model. …”

State dependence of stimulus-induced variability tuning in macaque MT by Joseph A. Lombardo (5851199)

The technical route of the study. by Hongliang Zou (20707270)

“…The highest root-mean-square error recorded was 2.72m in five sequences from a multi-modal multi-scene ground robot dataset, which was significantly lower than competing approaches. …”

Point cloud fusion instance effect. by Hongliang Zou (20707270)

“…The highest root-mean-square error recorded was 2.72m in five sequences from a multi-modal multi-scene ground robot dataset, which was significantly lower than competing approaches. …”

Experimental results in the SubT-MRS dataset. by Hongliang Zou (20707270)

“…The highest root-mean-square error recorded was 2.72m in five sequences from a multi-modal multi-scene ground robot dataset, which was significantly lower than competing approaches. …”

PSD curves of cells at different densities. by Mingkun Pang (11873753)

Systemic effects in naïve mice injected with immunomodulatory lectin ArtinM by Patrícia Kellen Martins Oliveira Brito (4543702)

“…IL-12, IFN-γ, TNF-α, and IL-10 measurements in the liver, kidney, spleen, heart, and lung homogenates revealed decreased IL-10 level in the heart and lung of mice injected with 5.0 μg ArtinM. …”

Influence of the order of addition of fusing partners on HCVpp 1a fusion inhibition by Arb. by Elodie Teissier (232354)

“…a<p>Arb (11.3 µM) was pre-incubated sequentially with either HCVpp or R₁₈-labeled liposomes or both for the indicated times at 37°C before initiating lipid mixing by decreasing pH to 5.0 as described in the legend to <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0015874#pone-0015874-g002" target="_blank">Figure 2</a>. …”

Repeated injection of GdCl₃ attenuates <i>S</i>. <i>japonicum</i> egg-induced hepatic granuloma inflammation. by Shengsheng Zheng (789770)