The MTH1 inhibitor TH588 demonstrates anti-tumoral effects alone and in combination with everolimus, 5-FU and gamma-irradiation in neuroendocrine tumor cells by Elke Tatjana Aristizabal Prada (833927)

“…The novel MTH1 inhibitor TH588 proved tremendous potential in terms of cancer cell eradication, yet its specificity has been questioned by recent reports, indicating that TH588 may also induce cancer cell death by alternative mechanisms than MTH1 inhibition. Here we used a panel of heterogeneous neuroendocrine tumor cells in order to assess cellular mechanisms and molecular signaling pathways implicated in the effects of TH588 alone as well as dual-targeting approaches combining TH588 with everolimus, cytotoxic 5-fluorouracil or γ-irradiation. …”

Image5_The integrated stress response protects against ER stress but is not required for altered translation and lifespan from dietary restriction in Caenorhabditis elegans.TIF by Zhengxin Ma (6309152)

Image_5_Allograft or Recipient ST2 Deficiency Oppositely Affected Cardiac Allograft Vasculopathy via Differentially Altering Immune Cells Infiltration.tif by Zhenggang Zhang (3161334)

Image_1_Silencing of miR-150-5p Ameliorates Diabetic Nephropathy by Targeting SIRT1/p53/AMPK Pathway.TIF by Wenmin Dong (10578710)

“…Consequently, we investigated the effect and mechanism of action of miR-150-5p in DN in vitro and in vivo. …”

Population effects are also evident in single subjects. by Philipp Schwedhelm (3558275)

“…For each subject, two Naka-Rushton equations per cue type were fit to the psychophysical data, revealing four informative coefficients. A decrease in <i>c</i>₅₀ between validly and invalidly cued trials indicates a contrast gain effect and an increase in <i>d</i>′_<i>max</i> a response gain effect. …”

Effects of VDR silencing on mitochondrial activity. by Marco Consiglio (275917)

Data_Sheet_1_Salidroside Promotes the Pathological α-Synuclein Clearance Through Ubiquitin-Proteasome System in SH-SY5Y Cells.doc by Tao Li (86810)

“…</p><p>Highlights: Sal protects cells and decreases the pSer129-α-syn protein level in 6-OHDA-induced impairmental and dysfunctional SH-SY5Y cells.…”

Image5_Elabela Attenuates the TGF-β1-Induced Epithelial-Mesenchymal Transition of Peritoneal Mesothelial Cells in Patients Receiving Peritoneal Dialysis.tif by Shunyun Xie (12898211)

“…Compared with those in patients with stage 5 chronic kidney disease who are not on dialysis, serum ELA levels in patients on PD increased with the improvement of residual renal function at PD duration <36 months and decreased to pre-dialysis levels at PD duration ≥36 months, suggesting that dialysis duration is the main risk factor affecting serum ELA levels in patients on PD. …”

In control (air exposed) guinea pigs electrical stimulation of the vagus nerves (3–30V, 0.2 ms pulse width, 15 Hz, 5 sec duration at 1 minute intervals) resulted in vagally induced... by Kirsten C. Verhein (460156)

“…V-05-013 partially prevented M₂ receptor dysfunction (C closed squares), while V-05-014 (B closed triangles) and V-05-015 (C closed inverted triangles) completely protected M₂ receptor function. …”

Table 5_CX3CR1 upregulation modulates microglial activation and preserves synapses in the hippocampus and frontal cortex of middle-aged mice.xlsx by Jinfeng Liu (32678)

Animal-related factors associated with moderate-to-severe diarrhea in children younger than five years in western Kenya: A matched case-control study by Anne Conan (628578)

“…Variables that were associated with decreased risk of MSD were washing hands after animal contact (matched odds ratio [MOR] = 0.2; 95% CI 0.08–0.7), and presence of adult sheep that were not confined in a pen overnight (MOR = 0.1; 0.02–0.5). …”

Image_5_A high interferon gamma signature of CD8+ T cells predicts response to neoadjuvant immunotherapy plus chemotherapy in gastric cancer.tif by Sen Li (155994)

Table_1_Altered Expression of ACE2 and Co-receptors of SARS-CoV-2 in the Gut Mucosa of the SIV Model of HIV/AIDS.XLSX by Shuang Hu (182425)

“…We investigated changes in the expression of ACE2 and other SARS-CoV-2 receptors and related pathways in virally inflamed gut by using the SIV infected rhesus macaque model of HIV/AIDS. …”

Efficacy of 3-day versus 5-day aprepitant regimens for long-delayed chemotherapy-induced nausea and vomiting in patients receiving cisplatin-based chemotherapy by Toshinobu Hayashi (17456110)

“…</p> <p>A 5-day regimen triplet antiemetic prophylaxis with APR decreased long-delayed vomiting compared with a 3-day regimen in patients receiving CDDP-based chemotherapy. …”

Table_5_A Large-Scale Genome-Based Survey of Acidophilic Bacteria Suggests That Genome Streamlining Is an Adaption for Life at Low pH.XLSX by Diego Cortez (239207)

Image_5_Aging-Dependent Altered Transcriptional Programs Underlie Activity Impairments in Human C9orf72-Mutant Motor Neurons.tiff by Daniel Sommer (133337)

Table5_Comparative transcriptome analysis reveals key candidate genes mediating ovarian development in Spodoptera frugiperda fed on two host plants.xlsx by Renwen Zheng (14118510)

Image_5_Loss of Deacetylation Enzymes Hdac6 and Sirt2 Promotes Acetylation of Cytoplasmic Tubulin, but Suppresses Axonemal Acetylation in Zebrafish Cilia.TIF by Paweł K. Łysyganicz (11041419)

Summary of results. Ab levels compared to controls. by Lisa Frehn (629123)

IFT43 plays a distinct role in IFT-A transport. by Bing Zhu (145649)

“…(F) Increase of IFT-B and decrease of IFT-A proteins in the flagella of <i>ift140</i> mutant cells. …”