Quantification of Histone Deacetylase Isoforms in Human Frontal Cortex, Human Retina, and Mouse Brain by Kyle W. Anderson (737084)

“…In human AD frontal cortex, HDAC1,2 decreased 32%, HDAC5 increased 47%, and HDAC6 increased 31% in comparison to age-matched controls. …”

DataSheet2_Pacbio Sequencing of PLC/PRF/5 Cell Line and Clearance of HBV Integration Through CRISPR/Cas-9 System.xlsx by Chia-Chen Chen (11283654)

“…We found that the sgRNA combinations could significantly decrease the level of HBsAg in the supernatant of PLC/PRF/5 cells, while accelerated cell proliferation. …”

DataSheet1_Pacbio Sequencing of PLC/PRF/5 Cell Line and Clearance of HBV Integration Through CRISPR/Cas-9 System.docx by Chia-Chen Chen (11283654)

“…We found that the sgRNA combinations could significantly decrease the level of HBsAg in the supernatant of PLC/PRF/5 cells, while accelerated cell proliferation. …”

Model-Driven Engineering of N‑Linked Glycosylation in Chinese Hamster Ovary Cells by Christopher S. Stach (7516934)

“…We rationally design, build, and test a total of 23 transgenic cell pools that express single or three-gene glycoengineering cassettes comprising a total of 100 kilobases of engineered DNA sequence. …”

Table5_Gypenoside L and Gypenoside LI Inhibit Proliferation in Renal Cell Carcinoma via Regulation of the MAPK and Arachidonic Acid Metabolism Pathways.xls by Hui Liu (33624)

Table_5_High-throughput screening of the effects of 90 xenobiotics on the simplified human gut microbiota model (SIHUMIx): a metaproteomic and metabolomic study.XLSX by Victor Castañeda-Monsalve (17989807)

“…Several food additives had significant effects on the relative abundances of bacterial species; for example, acid orange 7 and saccharin led to a 75% decrease in Clostridium butyricum, with saccharin causing an additional 2.5-fold increase in E. coli compared to the control. …”

Image_5_High-throughput screening of the effects of 90 xenobiotics on the simplified human gut microbiota model (SIHUMIx): a metaproteomic and metabolomic study.pdf by Victor Castañeda-Monsalve (17989807)

“…Several food additives had significant effects on the relative abundances of bacterial species; for example, acid orange 7 and saccharin led to a 75% decrease in Clostridium butyricum, with saccharin causing an additional 2.5-fold increase in E. coli compared to the control. …”

Image_5_CD209/CD14+ Dendritic Cells Characterization in Rheumatoid and Psoriatic Arthritis Patients: Activation, Synovial Infiltration, and Therapeutic Targeting.tif by Viviana Marzaioli (3484127)

“…Furthermore, we demonstrated that JAK/STAT inhibition can be used as a therapeutic strategy to decrease the inflammatory state of the pathogenic CD209/CD14⁺ DC.…”

Image_1_APPsα rescues CDK5 and GSK3β dysregulation and restores normal spine density in Tau transgenic mice.tif by Danny Baltissen (14507072)

“…Here, we examined the potential of APPsα to regulate two major Tau kinases, GSK3β and CDK5 in THY-Tau22 mice, a widely used mouse model of tauopathy. …”

5C analysis of the Epidermal Differentiation Complex locus reveals distinct chromatin interaction networks between gene-rich and gene-poor TADs in skin epithelial cells by Krzysztof Poterlowicz (4408261)

“…TADs are principle units of the genome folding and represents the <a href="https://en.wikipedia.org/wiki/DNA" target="_blank">DNA</a> regions within which DNA interacts more frequently and less frequently across the TAD boundary. Here, we used Chromatin Conformation Capture Carbon Copy (5C) technology to characterize spatial chromatin interaction network in the 3.1 Mb Epidermal Differentiation Complex (EDC) locus harbouring 61 functionally related genes that show lineage-specific activation during terminal keratinocyte differentiation in the epidermis. 5C data validated by 3D-FISH demonstrate that the EDC locus is organized into several TADs showing distinct lineage-specific chromatin interaction networks based on their transcription activity and the gene-rich or gene-poor status. …”

Image_5_Epidemiological and demographic drivers of lung cancer mortality from 1990 to 2019: results from the global burden of disease study 2019.tif by Yaguang Fan (15415049)

“…</p>Results<p>Despite a non-significant decrease in ASMR [EAPC = −0.31, 95% confidence interval (CI): −1.1 to 0.49], the number of deaths from lung cancer increased by 91.8% [95% uncertainty interval (UI): 74.5–109.0%] between 1990 and 2019. …”

DataSheet_1_Avidity engineering of human heavy-chain-only antibodies mitigates neutralization resistance of SARS-CoV-2 variants.docx by Wenjuan Du (393238)

“…We demonstrate that the tethered design mitigates the substantial decrease in spike trimer affinity seen for escape mutations for the hexamer components. …”

Table_5_In vitro inhibition of Pseudomonas aeruginosa PAO1 biofilm formation by DZ2002 through regulation of extracellular DNA and alginate production.xlsx by Jiaze Dai (17764467)

Table_1_Synthetic antimicrobial peptides Bac-5, BMAP-28, and Syn-1 can inhibit bovine respiratory disease pathogens in vitro.DOCX by Santiago Cornejo (19366597)

“…Moreover, we showed that BMAP-28 and Bac-5 can be used together to inhibit Mh growth. …”

Table_5_Prospective Study Reveals Host Microbial Determinants of Clinical Response to Fecal Microbiota Transplant Therapy in Type 2 Diabetes Patients.xlsx by Dafa Ding (6548732)

“…We observed a statistically significant decrease in HbA1c% (from 7.565 ± 0.148 to 7.190 ± 0.210, p<0.01), blood glucose (from 8.483 ± 0.497 to 7.286 ± 0.454 mmol/L, p<0.01), and uric acid (from 309.4 ± 21.5 to 259.1 ± 15.8 µmol/L, p<0.01) while a significant increase in postprandial C-peptide (from 4.503 ± 0.600 to 5.471 ± 0.728 ng/ml, p<0.01) at 12 weeks after FMT. …”

Time series and cumulative statistic table. by Pierre Ganault (17972799)

“…N₂O emissions decreased with macropore volume in the deepest layer, likely due to the presence of fewer anaerobic microsites. …”

Covariables summary statistics table. by Pierre Ganault (17972799)

“…N₂O emissions decreased with macropore volume in the deepest layer, likely due to the presence of fewer anaerobic microsites. …”

Raw data. by Jia Zhu (135506)

“…Following the completion of the test under intact conditions, fusion products were implanted into each specimen in segment C4-C5 in the following order: Zero-P, NZ, P + C. Biomechanical results revealed that the ROM of the surgical segment had decreased significantly under six basic working conditions following NZ implantation. …”

Summary statistic table of last week gas fluxes. by Pierre Ganault (17972799)

“…N₂O emissions decreased with macropore volume in the deepest layer, likely due to the presence of fewer anaerobic microsites. …”

Covariables summary statistics table. by Pierre Ganault (17972799)

“…N₂O emissions decreased with macropore volume in the deepest layer, likely due to the presence of fewer anaerobic microsites. …”