Image_5_Risk stratification based on DNA damage-repair-related signature reflects the microenvironmental feature, metabolic status and therapeutic response of breast cancer.tif by Chunzhen Li (14835418)

Image_1_EZH2/EHMT2 Histone Methyltransferases Inhibit the Transcription of DLX5 and Promote the Transformation of Myelodysplastic Syndrome to Acute Myeloid Leukemia.TIFF by Zhuanzhen Zheng (11215866)

“…Levels of H3K27me3/H3K9me2 were decreased by EZH2/EHMT2 inhibitor (EPZ-6438/BIX-01294), and changes of DLX5 expression and cell proliferation were observed. …”

Data_Sheet_1_Loud noise-exposure changes the firing frequency of subtypes of layer 5 pyramidal neurons and Martinotti cells in the mouse auditory cortex.docx by Ingrid Nogueira (15407156)

“…Imaging and in vivo studies show that noise exposure affects the auditory cortex; however, cellular mechanisms of tinnitus generation are unclear.</p>Methods<p>Here we compare membrane properties of layer 5 (L5) pyramidal cells (PCs) and Martinotti cells expressing the cholinergic receptor nicotinic alpha 2 subunit gene (Chrna2) of the primary auditory cortex (A1) from control and noise-exposed (4–18 kHz, 90 dB, 1.5 h, followed by 1.5 h silence) 5–8 week old mice. …”

Image_1_Downregulation of miR-181b-5p Inhibits the Viability, Migration, and Glycolysis of Gallbladder Cancer by Upregulating PDHX Under Hypoxia.jpeg by Yiyu Qin (596247)

“…GBC cell viability was significantly decreased under hypoxia, and these decreases were exacerbated by miR-181b-5p antagomir. …”

Table_1_EZH2/EHMT2 Histone Methyltransferases Inhibit the Transcription of DLX5 and Promote the Transformation of Myelodysplastic Syndrome to Acute Myeloid Leukemia.DOCX by Zhuanzhen Zheng (11215866)

“…Levels of H3K27me3/H3K9me2 were decreased by EZH2/EHMT2 inhibitor (EPZ-6438/BIX-01294), and changes of DLX5 expression and cell proliferation were observed. …”

Image_2_Downregulation of miR-181b-5p Inhibits the Viability, Migration, and Glycolysis of Gallbladder Cancer by Upregulating PDHX Under Hypoxia.jpeg by Yiyu Qin (596247)

“…GBC cell viability was significantly decreased under hypoxia, and these decreases were exacerbated by miR-181b-5p antagomir. …”

Data Sheet 5_Assessing the disease burden of lower respiratory infections attributable to particulate matter pollution: trends from 1990 to 2021 and projections for 2022-2050.pdf by Erman Wu (19021269)

“…A critical epidemiological transition emerged: APMP became predominant in high-income regions (approaching 100% of PMP burden), while HAP dominated in low-SDI settings (ASMR: 26.12 per 100,000). …”

Punicalagin ameliorates lipopolysaccharide-induced inflammatory response in dental pulp cells via inhibition of the NF-κB/Wnt5a-ROR2 pathway by Yumeng Yang (8155002)

“…</p> <p>PCG demonstrated an anti-inflammatory effect in LPS-induced DPCs by targeting the NF-κB/Wnt5a-ROR2 signaling pathway.</p> <p></p> <p>This schematic illustration demonstrates that PCG ameliorates LPS-elicited pulpitis by decreasing the expression of the proteins associated with the NF-κB signaling pathway and its downstream Wnt5a/ROR2 pathway and by reducing the production of inflammatory molecules.…”

Video5_The microglial innate immune receptor TREM2 participates in fear memory formation through excessive prelimbic cortical synaptic pruning.mp4 by Le-le Zhang (477674)

Table_5_Metagenomic Next-Generation Sequencing in the Diagnosis of HHV-1 Reactivation in a Critically Ill COVID-19 Patient: A Case Report.XLSX by Lei Shi (8144)

Image_5_Species identity and combinations differ in their overall benefits to Astragalus adsurgens plants inoculated with single or multiple endophytic fungi under drought conditio... by Yi-Ling Zuo (6943376)

Image_5_Increased atherosclerotic plaque in AOC3 knock-out in ApoE−/− mice and characterization of AOC3 in atherosclerotic human coronary arteries.tiff by Anna Filip (13776673)

Table5_Use of non-specific immunoglobulins in Catalonia in three third-level hospitals: a descriptive analysis of a hospital-prescribed medication registry.docx by J. Riera-Arnau (20431328)

Image_2_JAK2V617F Mutation Promoted IL-6 Production and Glycolysis via Mediating PKM1 Stabilization in Macrophages.tif by Rongqing Li (2253712)

“…We, therefore, established JAK2^V617F-expressing murine macrophages (JAK2^V617F macrophages) and found that the levels of p-STAT3 were markedly elevated in JAK2^V617F macrophages in association with an increase in IL-6 production. …”

Circular RNA circ_0003028 contributes to tumorigenesis by regulating GOT2 via miR-1298-5p in non-small cell lung cancer by Hongjun Guan (4840134)

“…The biological role of circ_0003028 on NSCLC tumor growth was examined by the xenograft tumor model <i>in vivo</i>. We reported that circ_0003028 and GOT2 were upregulated, and miR-1298-5p was decreased in NSCLC tissues and cells. …”

Image_1_Comprehensive Proteomic Profiling of Urinary Exosomes and Identification of Potential Non-invasive Early Biomarkers of Alzheimer’s Disease in 5XFAD Mouse Model.tif by Zhiqi Song (8684007)

“…</p>Objective<p>To investigate the potential non-invasive early biomarkers of AD in 5XFAD mouse model, we investigate the proteome of urinary exosomes present in 1-month-old (before amyloid-β accumulation) 5XFAD mouse models and their littermate controls. …”

Image_1_JAK2V617F Mutation Promoted IL-6 Production and Glycolysis via Mediating PKM1 Stabilization in Macrophages.tif by Rongqing Li (2253712)

“…We, therefore, established JAK2^V617F-expressing murine macrophages (JAK2^V617F macrophages) and found that the levels of p-STAT3 were markedly elevated in JAK2^V617F macrophages in association with an increase in IL-6 production. …”

Table_5_Liraglutide Inhibits Osteoclastogenesis and Improves Bone Loss by Downregulating Trem2 in Female Type 1 Diabetic Mice: Findings From Transcriptomics.docx by Jie Yu (150626)

Table_1_Preclinical characterization of amubarvimab and romlusevimab, a pair of non-competing neutralizing monoclonal antibody cocktail, against SARS-CoV-2.docx by Yun Ji (464484)

“…However, the continuous virus evolution requires diverse mAb options to combat variants. Here we describe two fully human mAbs, amubarvimab (BRII-196) and romlusevimab (BRII-198) that bind to non-competing epitopes on the receptor binding domain (RBD) of spike protein and effectively neutralize SARS-CoV-2 variants. …”

Table_5_Dietary supplementation of squalene increases the growth performance of early-weaned piglets by improving gut microbiota, intestinal barrier, and blood antioxidant capacity... by Yang Gao (18005)

“…The villus height (P < 0.001) and V/C ratio (villus height/crypt depth, P < 0.001) of the jejunum were significantly increased in the SQ group, while the crypt depth (P < 0.01) was decreased compared to the CON group. …”