OSU-HDAC-44 decreased RhoA activity via srGAP1 induction, leading to F-actin dysregulation. by Yen-An Tang (187547)

“…<p>(<b>A</b>) Chromatin-immunoprecipitation-PCR analyses confirmed that treatment with 2.5 µM OSU-HDAC-44 for 2 h induced acetylation of histone H3 (H3K9K14Ac) in the promoter region of <i>srGAP1</i>, <i>NR4A1</i> and <i>FOXO4</i> genes. …”

VAMP2 decreases 5-HT uptake and SERT cell surface expression in HEK-293 MSR cells by reducing the delivery rate of the transporter to the plasma membrane. by Heidi Kaastrup Müller (570207)

Oxidation of glycans results in a decreased production of IL-4 and IL-10 and an increase of IFNγ by parasite specific splenocytes. by Ernesto Rodríguez (840670)

Overexpression of PR decreases Myc expression and activity. by Tamar Kavlashvili (849072)

Plume encounters are preceded by increased amplitude of head-pitch motion in the active search (5–14 Hz) band, and immediately followed by decreased head-pitch motion. by Mohammad F. Tariq (10727478)

The flavanone homoeriodictyol increases SGLT-1-mediated glucose uptake but decreases serotonin release in differentiated Caco-2 cells - Fig 2 by Barbara Lieder (3743008)

Decreased MUFA/SFA ratio in total lipids of lung cancer cells treated with a small molecule inhibitor of SCD activity. by Natalia Scaglia (370865)

GXMGal effect on Th1 response. by Eva Pericolini (290617)

DHEA decreases the apoptotic loss of TrkA positive sensory neurons in dorsal root ganglia of NGF null mouse embryos. by Iakovos Lazaridis (223341)

Decreased echinocandin susceptibility in <i>Candida parapsilosis</i> causing candidemia and emergence of a pan-echinocandin resistant case in China by Yating Ning (11264310)

GXMGal effect on different subsets of Treg cells. by Eva Pericolini (290617)

GXMGal effect on Th17 response. by Eva Pericolini (290617)

Mean SARS-CoV-2 viral load log 10 between groups. by Bruno Martins Tomazini (6509528)

“…</p><p>Results</p><p>From September 25, 2021, to February 3, 2022, 153 patients were randomized. The mean decay rate in SARS-CoV-2 viral load log₁₀ within 10 days was -3.75 (95% CI, -4.11; -3.19) in the placebo group, -3.83 (95% CI, -4.40; -2.27) in the halofuginone 0.5mg group and -4.13 (95% CI, -4.69; -3.57) in the halofuginone 1mg group, with no statistically significant difference in between placebo vs. halofuginone 0.5mg (mean difference -0.08; 95% CI -0.82 to 0.66, p = 0.96) and between placebo vs. halofuginone 1mg (mean difference -0.38; 95% CI, -1.11; 0.36, p = 0.41). …”

GXMGal effect on Treg cell response. by Eva Pericolini (290617)

Naturally occurring antibodies against serum amyloid A reduce IL-6 release from peripheral blood mononuclear cells - Fig 5 by Tadeja Kuret (5059433)

Fig 5 - by Felix Bosch (10024550)

Research data for paper: Disrupting a (far-right) mobilisation discourages bystander support by decreasing perceived organisational efficacy and legitimacy by Carina Hoerst (7143209)

The invasive tropical tanner grass decreases diversity of the native aquatic macrophyte community at two scales in a subtropical tidal river by Rayana Yumi Sato (12656962)

Bortezomib in combination with the PLK1 inhibitor BI 2536 induces a significant downregulation of the total levels and phosphorylation of Bcr-Abl, a decrease of downstream phosphorylated STAT5 and a caspase-dependent cell death in TKIs-resistant and –sensitive K562 cell lines. by Octavian Bucur (470431)

“…K562 and K562-R cells were treated with 9nM bortezomib and 8nM BI 2536 for 60h, followed by the detection of Bcr-Abl and phosphorylated STAT5. The combined treatment resulted in a marked decrease of the total levels of Bcr-Abl, which correlates with a decrease in the phosphorylation of the downstream STAT5 protein, in both K562 and K562-R cells. β-Actin was used as an internal loading control. …”

Recapitulation of Tumor Heterogeneity and Molecular Signatures in a 3D Brain Cancer Model with Decreased Sensitivity to Histone Deacetylase Inhibition by Stuart J. Smith (111275)