Hyperlipidemia-Associated Renal Damage Decreases Klotho Expression in Kidneys from ApoE Knockout Mice by Cristina Sastre (503532)

“…Hyperlipidemia accelerates the progression of renal damage, but the mechanisms of the deleterious effects of hyperlipidemia remain unclear.</p><p>Methods</p><p>We evaluated whether hyperlipidemia modulates Klotho expression in kidneys from C57BL/6 and hyperlipidemic apolipoprotein E knockout (ApoE KO) mice fed with a normal chow diet (ND) or a Western-type high cholesterol-fat diet (HC) for 5 to 10 weeks, respectively.…”

Gramine Derivatives Targeting Ca²⁺ Channels and Ser/Thr Phosphatases: A New Dual Strategy for the Treatment of Neurodegenerative Diseases by Rocío Lajarín-Cuesta (1530580)

“…Hence, we propose this multitarget approach as a new and promising strategy for the treatment of neurodegenerative diseases.…”

FEF inactivation decreased ipsilesional and contralesional microsaccade peak velocities, both before and after cue onset. by Tyler R. Peel (2935848)

“…<p>(<b>A</b>) Unilateral (left) FEF inactivation reduced peak velocity for contralesional microsaccades independently of amplitude in our example monkey DZ and also decreased peak velocities for ipsilesional microsaccades. …”

Image_1_Astaxanthin supplementation counters exercise-induced decreases in immune-related plasma proteins.TIFF by David C. Nieman (322662)

“…Short-term astaxanthin supplementation (8 mg/day during a 4-week period) provided immune support for runners engaging in a vigorous 2.25 h running bout and uniquely countered decreases in plasma immunoglobulin levels.…”

Down-regulation of Bim in EBV-positive cells is not due to proteosomal degradation or decreased mRNA stability. by Kostas Paschos (262658)

Pharmacodynamic Profile of CCX168 in Healthy Human Volunteers. by Pirow Bekker (392139)

“…(A) C5a-induced upregulation of CD11b on the surface of neutrophils in whole blood collected in the placebo group (●), and at 2 hours (♦) and 24 hours (◊) after a single dose of 10 mg CCX168, at 2 hours (▲) and 12 hours (Δ) after a single dose of 30 mg CCX168, and 2 hours (■) and 12 hours (□) after a single dose of 100 mg CCX168. …”

Ivermectin significantly decreases <i>L</i>. <i>loa</i> mf in BALB/c mice. by Rene Bilingwe Ayiseh (6900296)

Decreased MMP-9 protein expression induced by STIP1 knockdown is independent of common signaling pathways. by Hsin-Shih Wang (8802)

“…(B) Decreased MMP-9 protein expression induced by siRNA knockdown of STIP1 was unaffected by exposure either to the DNA methylation inhibitor 5-aza-2’-deoxycytidine (AZA; 10 μM) or the histone deacetylase inhibitor trichostatin A (TSA; 20 nM). …”

DataSheet1_Calmodulin mutations affecting Gly114 impair binding to the NaV1.5 IQ-domain.docx by Malene Brohus (840080)

“…We therefore hypothesized that the G114R variant specifically would interfere with Na_V1.5 binding. …”

Pirfenidone stabilized the mitochondrial membrane potential (MMP) and decreased intracellular ROS in renal proximal tubular cells. by Jun-Feng Chen (494741)

Image_1_Ozone Decreased Enteric Methane Production by 20% in an in vitro Rumen Fermentation System.TIFF by Lucy Zhao (9589874)

“…Ozone treatment decreased total gas production by 15.4%, most notably CH₄ production by 20.4%, and CH₄ gas concentration by 5.8%, without compromising dry matter digestibility (DMD) of either maize silage or grain concentrates. …”

Table_1_Ozone Decreased Enteric Methane Production by 20% in an in vitro Rumen Fermentation System.DOCX by Lucy Zhao (9589874)

“…Ozone treatment decreased total gas production by 15.4%, most notably CH₄ production by 20.4%, and CH₄ gas concentration by 5.8%, without compromising dry matter digestibility (DMD) of either maize silage or grain concentrates. …”

Table_1_Decreased Treg Cell and TCR Expansion Are Involved in Long-Lasting Graves’ Disease.docx by Ziyi Chen (458298)

“…Specifically, the expression of pro-inflammatory and chemotactic genes (IL1B, IL13, IL8, and CCL4) was increased in pGD, whereas Th17 and Treg cells associated genes (RORC, CARD9, STAT5A, and SATB1) decreased in pGD. Additionally, TCR diversity was negatively correlated with the expression of pro-inflammatory or chemotactic genes (FASLG, IL18R1, CCL24, and CCL14). …”

Image_3_Decreased Treg Cell and TCR Expansion Are Involved in Long-Lasting Graves’ Disease.tif by Ziyi Chen (458298)

“…Specifically, the expression of pro-inflammatory and chemotactic genes (IL1B, IL13, IL8, and CCL4) was increased in pGD, whereas Th17 and Treg cells associated genes (RORC, CARD9, STAT5A, and SATB1) decreased in pGD. Additionally, TCR diversity was negatively correlated with the expression of pro-inflammatory or chemotactic genes (FASLG, IL18R1, CCL24, and CCL14). …”

Image_1_Decreased Treg Cell and TCR Expansion Are Involved in Long-Lasting Graves’ Disease.tif by Ziyi Chen (458298)

“…Specifically, the expression of pro-inflammatory and chemotactic genes (IL1B, IL13, IL8, and CCL4) was increased in pGD, whereas Th17 and Treg cells associated genes (RORC, CARD9, STAT5A, and SATB1) decreased in pGD. Additionally, TCR diversity was negatively correlated with the expression of pro-inflammatory or chemotactic genes (FASLG, IL18R1, CCL24, and CCL14). …”

Image_2_Decreased Treg Cell and TCR Expansion Are Involved in Long-Lasting Graves’ Disease.tif by Ziyi Chen (458298)

“…Specifically, the expression of pro-inflammatory and chemotactic genes (IL1B, IL13, IL8, and CCL4) was increased in pGD, whereas Th17 and Treg cells associated genes (RORC, CARD9, STAT5A, and SATB1) decreased in pGD. Additionally, TCR diversity was negatively correlated with the expression of pro-inflammatory or chemotactic genes (FASLG, IL18R1, CCL24, and CCL14). …”

A647D mutation decreases I_Na of WT and P1332L when co-expressed. by Jie Liu (15128)

Supplementary Material for: Clinical Implications of Decreased Computed Tomography Value after Ramucirumab in Advanced Gastric Cancer by Izawa N. (6834062)

“…<b><i>Objectives:</i></b> This study aimed to evaluate whether a decrease of computed tomography (CT) value for tumors serves as a predictive marker in patients with advanced gastric cancer (aGC) who have undergone chemotherapy with vascular epithelial growth factor receptor 2 inhibitor (ramucirumab). …”

Supplementary Material for: Enhanced Recovery after Surgery for Radical Cystectomy Decreases Postoperative Complications at Different Times by Lannes F. (11465377)

“…<b><i>Methods:</i></b> We performed a retrospective monocentric study using prospectively maintained databases including all patients treated by radical cystectomy between January 2015 and July 2019. …”

Fully Transparent and Rollable Electronics by Mallory Mativenga (1681909)

“…As the CPI supports processing temperatures >300 °C, TFT performance on plastic is similar to that on glass, with typical field-effect mobility, turn-on voltage, and subthreshold voltage swing of 12.7 ± 0.5 cm²/V·s, −1.7 ± 0.2 V, and 160 ± 29 mV/dec, respectively. …”