Moving Pieces in a Cellular Puzzle: A Cryptic Peptide from the Scorpion Toxin Ts14 Activates AKT and ERK Signaling and Decreases Cardiac Myocyte Contractility via Dephosphorylation... by Diana P. Goméz-Mendoza (9104908)

Deletion of murine <i>Rhoh</i> leads to de-repression of <i>Bcl-6</i> via decreased KAISO levels and accelerates a malignancy phenotype in a murine model of lymphoma by Hiroto Horiguchi (3215001)

“…The loss of Rhoh in Bcl-6^Tg mice led to a more rapid disease progression. Mechanistically, we demonstrated that deletion of Rhoh in these murine lymphoma cells was associated with decreased levels of the RhoH binding partner KAISO, a dual-specific Zinc finger transcription factor, de-repression of KAISO target Bcl-6, and downregulation of the BCL-6 target Blimp-1. …”

Specific activity of Pyruvate Kinase (PK)-M2 in both of human pancreatic tumor cell lines. by Archana Pandita (627056)

Average negative, positive, and net work data for all the walking conditions: Level (0°), downhill (−5°,−10°), and uphill (+5°,+10°) (n = 12). by Nikolaos Papachatzis (12959894)

“…During uphill walking, the knee increased the magnitude of net positive work (0° vs. 10°: p = 0.005; +5° vs. +10°: p = 0.012). <b>(D)</b> The hip increased the magnitude of the net negative work when the slope of walking decreased (0° vs. −5°: p = 0.002; −0° vs. −10°: p = 0.002), while uphill walking shifted and increased the hip’s net mechanical behavior (0° vs. +5°: p = 0.002; 0° vs +10°: p = 0.002; +5° vs. +10°: p = 0.002). …”

Representative images of immunofluorescence staining and colocalization analysis of nanoprobes for P88 and laminin in T98G cells. by Juan F. Zapata-Acevedo (18349423)

Representative images of immunofluorescence staining and colocalization analysis of nanoprobes for P88 and laminin in hCMEC/D3 cells. by Juan F. Zapata-Acevedo (18349423)

Different requirements for ALIX and TSG101 in the lysosomal transport processes of PEDV and PEAV. by Xiongnan Chen (13307178)

Changes in expression of myelin basic protein (MBP) and neurofilament heavy polypeptide (NF200) in the sciatic nerves of PSNL-exposed rats and the effects of treatment with MSCs. by Kanako Miyano (3805288)

Distribution of mRNAs on polysome profiles as a measurement of their translation efficiency. by Mohammed R. Alzahrani (13229154)

Data_Sheet_1_rdHSV-CA8 non-opioid analgesic gene therapy decreases somatosensory neuronal excitability by activating Kv7 voltage-gated potassium channels.docx by Munal B. Kandel (18526539)

Symmetrical dimethylation of SmB is decreased, its interaction with PRMT5 and the assembly of U snRNPs are impaired in <i>Tdrd6</i>^<i>-/-</i> primary spermatocytes by Müge Akpınar (3815143)

Eutrophication and predator presence overrule the effects of temperature on mosquito survival and development by Maarten Schrama (2924811)

“…Results indicate that 1) irrespective of temperature, predator presence decreased mosquito larval survival and adult emergence by 20–50%, 2) nutrient additions led to a 3-4-fold increase in mosquito adult emergence and a 2-day decrease in development time across all temperature treatments, 3) neither predation, nutrient additions nor temperature had strong effects on the emergence and development rate of controphic <i>Ch</i>. …”

Effects of SARS-CoV-2 Alpha, Beta, and Delta variants, age, vaccination, and prior infection on infectiousness of SARS-CoV-2 infections by Qassim, Suelen H.

“…Using the cycle threshold (Ct) value of an RT-qPCR-positive test to proxy the inverse of infectiousness, we investigated infectiousness of SARS-CoV-2 infections by variant, age, sex, vaccination status, prior infection status, and reason for testing in a random sample of 18,355 RT-qPCR-genotyped infections. …”
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Table_5_Disease Activity-Associated Alteration of mRNA m5 C Methylation in CD4+ T Cells of Systemic Lupus Erythematosus.xlsx by Gangqiang Guo (3278922)

“…Additionally, decreased m⁵C levels, albeit increased number of m⁵C-containing mRNAs, were observed in CD4⁺ T cells of patients with SLE compared with that in CD4⁺ T cells of HCs. m⁵C site distribution in mRNA transcripts was highly conserved and enriched in mRNA translation initiation sites. …”

Glycochenodexycholic (GCDCA) causes lumen obstruction and subepithelial fibrosis of neonatal extrahepatic bile ducts (EHBDs), while ursodeoxycholic acid (UDCA) attenuates GCDCA tox... by Miri Dotan (12250909)

“…Immunofluorescent staining for the cholangiocyte marker K19 (green) and the myofibroblast marker α-SMA (red) demonstrated an ameliorating effect of UDCA, with increased lumen integrity and decreased fibrosis. Scale bar, 50 μm. (b) Quantification of the total α-SMA positive area in the bile ducts (control 1 ± 0.255 (n = 20), GCDCA 4.19 ± 0.87 (n = 21), GCDCA +UDCA 1.87 ± 0.48 (n = 15)). …”

DataSheet2_Loss-of-function N178T variant of the human P2Y4 receptor is associated with decreased severity of coronary artery disease and improved glucose homeostasis.ZIP by Michael Horckmans (14206388)

“…The relevance of these data has, however, not been explored to date in humans. In a population study comprising 50 patients with coronary artery disease (CAD) and 50 age-matched control individuals, we analyzed P2RY4 mutations and their potential association with CAD severity and fasting plasma parameters. …”

DataSheet1_Loss-of-function N178T variant of the human P2Y4 receptor is associated with decreased severity of coronary artery disease and improved glucose homeostasis.ZIP by Michael Horckmans (14206388)

“…The relevance of these data has, however, not been explored to date in humans. In a population study comprising 50 patients with coronary artery disease (CAD) and 50 age-matched control individuals, we analyzed P2RY4 mutations and their potential association with CAD severity and fasting plasma parameters. …”

DataSheet3_Loss-of-function N178T variant of the human P2Y4 receptor is associated with decreased severity of coronary artery disease and improved glucose homeostasis.ZIP by Michael Horckmans (14206388)

“…The relevance of these data has, however, not been explored to date in humans. In a population study comprising 50 patients with coronary artery disease (CAD) and 50 age-matched control individuals, we analyzed P2RY4 mutations and their potential association with CAD severity and fasting plasma parameters. …”

DataSheet4_Loss-of-function N178T variant of the human P2Y4 receptor is associated with decreased severity of coronary artery disease and improved glucose homeostasis.ZIP by Michael Horckmans (14206388)

“…The relevance of these data has, however, not been explored to date in humans. In a population study comprising 50 patients with coronary artery disease (CAD) and 50 age-matched control individuals, we analyzed P2RY4 mutations and their potential association with CAD severity and fasting plasma parameters. …”

The overall negative effects played by IFITM3 during viral spread are the result of two concomitant antiviral mechanisms, acting in the protection of target cells as well as in the... by Kevin Tartour (514249)