RBM10 promotes transformation-associated processes in small cell lung cancer and is directly regulated by RBM5 by Julie J. Loiselle (4183750)

“…Interestingly, the earliest and most frequent genetic alteration associated with lung cancers involves a lesion in the region to which the RNA binding protein <i>RBM5</i> maps. We have recently shown that a decrease in <i>RBM5</i> expression may be a key step in SCLC development, as RBM5 regulated many transformation-associated processes in SCLC cells. …”

Ternary Dinuclear Copper(II) Complexes of a Hydroxybenzamide Ligand with Diimine Coligands: the 5,6-dmp Ligand Enhances DNA Binding and Cleavage and Induces Apoptosis by Sethu Ramakrishnan (2081944)

“…In contrast to the increase in relative viscosities of DNA bound to <b>2</b>–<b>4</b>, a decrease in viscosity of DNA bound to <b>1</b> is observed, indicating a shortening of the DNA chain length through formation of kinks or bends. …”

Islet2a morphant, but not mutant, larvae have a reduced number of dSMNs. by Rosa L. Moreno (5434796)

“…(C) Injection of the T-MO led to a decrease in the number of zn8⁺ neurons that coexpressed gfp. …”

Results of a t-test comparison between the control and waste settings (semantic differential method). by Ernest Bielinis (9954434)

The 14-3-3η chaperone protein promotes antiviral innate immunity via facilitating MDA5 oligomerization and intracellular redistribution by Jhih-Pu Lin (6321470)

“…Upon RNA ligand stimulation, we observed the redistribution of MDA5 from the cytosol to mitochondrial membrane fractions. …”

General Methodology to Optimize Damping Functions to Account for Charge Penetration Effects in Electrostatic Calculations Using Multicentered Multipolar Expansions by Araken S. Werneck (2458621)

“…We developed a methodology to optimize exponential damping functions to account for charge penetration effects when computing molecular electrostatic properties using the multicentered multipolar expansion method (MME). …”

General Methodology to Optimize Damping Functions to Account for Charge Penetration Effects in Electrostatic Calculations Using Multicentered Multipolar Expansions by Araken S. Werneck (2458621)

“…We developed a methodology to optimize exponential damping functions to account for charge penetration effects when computing molecular electrostatic properties using the multicentered multipolar expansion method (MME). …”

Video_5_Exploring Zebrafish Larvae as a COVID-19 Model: Probable Abortive SARS-CoV-2 Replication in the Swim Bladder.avi by Valerio Laghi (12228728)

“…<p>Animal models are essential to understanding COVID-19 pathophysiology and for preclinical assessment of drugs and other therapeutic or prophylactic interventions. We explored the small, cheap, and transparent zebrafish larva as a potential host for SARS-CoV-2. …”

Proteomic Analysis of eIF5B Silencing-Modulated Proteostasis by Xu Jiang (1602100)

“…Autonomous downregulation of the mitogen-activated protein kinase (MAPK) signaling pathway was identified as confirmed by western blotting and qPCR. We proposed that deactivation of MAPK pathway modulated proteostasis and induced prolonged S-phase of the cell-cycle, contributing to the slow growth of eIF5B-KN cells. eIF5B silencing also inactivated the mTOR pathway, downregulated glutamine transporters, enhanced autophagy, and decreased 28S rRNA and 5.8S rRNA expression levels which were reversed by restoration of eIF5B expression. …”

Effect on the metabolic clearance rate (MCR) of meranzin hydrate (MH) under the inhibition of recombinant CYP1A2 and CYP2C19. by Xi Huang (12172)

“…The MCRs of MH were significantly decreased compared with that of the control for CYP1A2 and CYP2C19, for both concentrations of MH.…”

Histological evaluation of joints after oral administration of GLME to rats with MIA-induced OA. by JooYeon Jhun (3797404)

Cyclin deficient virus has a similar cellular distribution to wild-type γHV68 during primary infection of C57BL/6J mice. by Brian F. Niemeyer (11707995)

Malaria severity: Possible influence of the E670G PCSK9 polymorphism: A preliminary case-control study in Malian children by Charles Arama (159942)

“…Here we examined the frequency distribution of one dominant (C679X) and two recessive (A443T, I474V) hypocholesterolemic polymorphisms as well as that of one recessive hypercholesterolemic polymorphism (E670G) among healthy and malaria-infected Malian children.…”

The Effect of a Novel Highly Selective Inhibitor of the Sodium/Calcium Exchanger (NCX) on Cardiac Arrhythmias in <i>In Vitro</i> and <i>In Vivo</i> Experiments - Fig 5 by Zsófia Kohajda (291183)

Table 5_A zebrafish model of crim1 loss of function has small and misshapen lenses with dysregulated clic4 and fgf1b expression.docx by Tien Le (634791)

Csf1r and Mer expression further define KC subsets in mouse liver. by Juan A. Santamaria-Barria (6655667)

Csf1r or Mer inhibition delays liver regeneration via suppression of Kupffer cells by Juan A. Santamaria-Barria (6655667)

“…At 36h after PH, Csf1r inhibition increased serum ALT and histological liver injury, and decreased liver cell proliferation. A small molecule inhibitor of Mer did not alter the percentage of KCs or their proliferation and just modestly delayed LR. …”

Hemolytic activities of hGRNL, bNK2A, and pNKL peptides on cattle red blood cells (RBCs). by Erika N. Biernbaum (12647386)

Csf1r inhibition, Mer inhibition, and clodronate liposomes have distinct biologic effects. by Juan A. Santamaria-Barria (6655667)

Key model inputs. by Demin Shi (15457271)

“…If the price of T-DXd decreased to $17.00/mg, $17.13/mg, and $14.07/mg, it would be cost-effective at a willingness to pay (WTP) threshold of $50,000/QALY in all HER2-low advanced BC patients, HER2+ advanced BC patients and HER2- advanced BC patients, respectively. …”