Butyrylation Meets Adipogenesis-Probed by a p300-Catalyzed Acylation-Specific Small Molecule Inhibitor: Implication in Anti-obesity Therapy by Aditya Bhattacharya (4499686)

“…Treatment of 3T3L1 cells with LTK-14A abolished adipogenesis with downregulation of pro-adipogenic genes along with inhibition of H4K5 butyrylation. Administering LTK-14A to high-fat diet-fed and genetically obese db/db mice led to attenuation/decrease in their weight gain. …”

Butyrylation Meets Adipogenesis-Probed by a p300-Catalyzed Acylation-Specific Small Molecule Inhibitor: Implication in Anti-obesity Therapy by Aditya Bhattacharya (4499686)

“…Treatment of 3T3L1 cells with LTK-14A abolished adipogenesis with downregulation of pro-adipogenic genes along with inhibition of H4K5 butyrylation. Administering LTK-14A to high-fat diet-fed and genetically obese db/db mice led to attenuation/decrease in their weight gain. …”

Ionic currents generated through a leaky patch (I_LP) generates a sodium leak conductance which is potentiated in low external calcium and is highly sensitive to Gd<sup>3... by Adrienne N. Boone (405848)

“…Less mobile cations like NMDG⁺ slows the inward electro-osmotic flow of ions compared to Na⁺ ions. Gd³⁺ has a high local charge density that titrates positive charges into the patch seal space, neutralizing the electrostatic repulsion of the negatively charged glass electrode and membrane, improving the seal resistance, and causing a decrease in leak current size. …”

The Oncogene PDRG1 Is an Interaction Target of Methionine Adenosyltransferases by Claudia Pérez (351604)

“…All these alterations result in a reduced content of the moderate (MAT I) and high V_max (MAT III) isoenzymes, whereas the low V_max (MAT II) isoenzyme increases and nuclear accumulation of MAT I is observed. …”

DataSheet_1_Non-coding RNAs derived from the foot-and-mouth disease virus genome trigger broad antiviral activity against coronaviruses.pdf by Miguel Rodríguez-Pulido (298809)

“…When the in vivo efficacy of the FMDV ncRNAs was assessed in K18-hACE2 mice, administration of naked ncRNA before intranasal SARS-CoV-2 infection significantly decreased the viral load and the levels of pro-inflammatory cytokines in the lungs compared with untreated infected mice. …”

Gut and nasal microbiome community overview. by Holly Kristin Arnold (14204655)

Effects of the transobturator tape procedure on overactive bladder symptoms and quality of life: a prospective study by Salih Polat (8185269)

“…Conclusions: MUS is not only a gold standard treatment in SUI but also presents as a promising treatment modality in stress-dominant MUI. …”

Doses of enzyme complex in a high-energy diet on performance and carcass traits of feedlot steers by Gabriela Letícia Delai Vigne (6015992)

“…<div><p>ABSTRACT The objective of this study was to evaluate the production performance and carcass traits of feedlot steers fed a high-energy diet supplemented with doses of an enzyme complex (0, 2.5, 5.0, and, 7.5 g animal−1 day−1). …”

Synthesis and Preclinical Validation of Novel Indole Derivatives as a GPR17 Agonist for Glioblastoma Treatment by Phung Nguyen (230474)

“…The <b>CHBC</b>–GPR17 interaction leads to a rapid decrease of cAMP and Ca²⁺. <b>CHBC</b> exhibits the cytotoxicity effect on GBM cells in a dose-dependent manner with an IC₅₀ of 85 μM, whereas the known agonist MDL29,951 showed a negligible effect. …”

PrA inhibited DC maturation responding to LPS and diminished DC-mediated T cell allostimulation. by Maomao Zhang (393240)

“…The highest dose induced a significant decrease in viable DC count, so only 5 nM and 20 nM were used in subsequent experiments. …”

Glyphosate alters the composition, but not density, of the <i>A</i>. <i>gambiae</i> midgut microbiota. by Daniel F. Q. Smith (10788903)

“…<p>(<b>A)</b> Glyphosate does not alter microbial density of the culturable mosquito midgut bacteria (grown on LB agar). …”

The Potential Connectivity of Waterhole Networks and the Effectiveness of a Protected Area under Various Drought Scenarios by Georgina O’Farrill (564895)

“…The Greater Calakmul Region of the Yucatan Peninsula (Mexico) has experienced a 16% decrease in precipitation over the last 50 years, which we hypothesise has affected water resource connectivity. …”

Table_1_Chemical-Shift-Encoded Magnetic Resonance Imaging and Spectroscopy to Reveal Immediate and Long-Term Multi-Organs Composition Changes of a 14-Days Periodic Fasting Interven... by Magalie Viallon (3140223)

“…Fat fraction, MRI relativity index T2^* and susceptibility (Chi), as well as Fatty acid composition, were calculated at all-time points.</p><p>Results: A decrease in body weight (BW: −9.5%), quadriceps muscle volume (−3.2%), Subcutaneous and Visceral Adipose Tissue (SAT −34.4%; VAT −20.8%), liver fat fraction (PDFF = 1.4 vs. 2.6 % at baseline) but increase in Spine Bone Marrow adipose tissue (BMAT) associated with a 10% increase in global adiposity fraction (PDFF: 54.4 vs. 50.9%) was observed. …”

Longitudinal fasting blood glucose patterns and arterial stiffness risk in a population without diabetes by Yuntao Wu (37012)

“…Multivariate regression model was used to estimate the difference of brachial-ankle pulse wave velocity levels and logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (95%CIs) of arterial stiffness risk, according to the fasting blood glucose trajectories.</p><p>Results</p><p>We identified five distinct fasting blood glucose trajectories and each of the trajectories was labeled according to its range and change over 2006–2010 survey: elevated-stable pattern (5.0% of participants), elevated-decreasing pattern (6.6%), moderate-increasing pattern (10.9%), moderate-stable pattern (59.3%), and low-stable pattern (18.2%). …”

Metabolic syndrome in pregnancy and risk for adverse pregnancy outcomes: A prospective cohort of nulliparous women by Jessica A. Grieger (6041222)

“…Women with MetS were at an increased risk for PE by a factor of 1.63 (95% CI 1.23 to 2.15) and for GDM by 3.71 (95% CI 2.42 to 5.67). …”

Developmental and Neurobehavioral Toxicity of Hexaphenoxycyclotriphosphazene: Implications for Its Safety as a Flame-Retardant Alternative to Triphenyl Phosphate by Ruobing Bai (4860043)

“…Here, using zebrafish larvae with TPhP as a benchmark, we systematically evaluated the developmental and neurobehavioral toxicity of HPCTP at environmentally relevant concentrations (50–5000 ng/L) from 6 to 120 h postfertilization. …”

Data_Sheet_1_Brain cortical alterations in COVID-19 patients with neurological symptoms.docx by Gretel Sanabria-Diaz (436165)

“…Additionally, we analyzed the cortical features and the association with inflammatory biomarkers in the cerebrospinal fluid (CSF) and plasma.…”

TMEM43 Mutation p.S358L Alters Intercalated Disc Protein Expression and Reduces Conduction Velocity in Arrhythmogenic Right Ventricular Cardiomyopathy by Vinayakumar Siragam (455948)

“…A heterozygous missense mutation in the transmembrane protein 43 (TMEM43) gene, p.S358L, has been genetically identified to cause autosomal dominant ARVC type 5 in a founder population from the island of Newfoundland, Canada. …”

Quantitative Microplate-Based Respirometry with Correction for Oxygen Diffusion by Akos A. Gerencser (526729)

“…Respirometry using modified cell culture microplates offers an increase in throughput and a decrease in biological material required for each assay. …”

Quantitative Microplate-Based Respirometry with Correction for Oxygen Diffusion by Akos A. Gerencser (526729)

“…Respirometry using modified cell culture microplates offers an increase in throughput and a decrease in biological material required for each assay. …”