Safety assessment of a novel C-type natriuretic peptide derivative and the mechanism of bone- and cartilage-specific toxicity by Takafumi Yotsumoto (4994390)

“…Furthermore, we searched for the biomarker related to the bone and cartilage toxicity using rats treated with ASB20123 at doses of 0.005, 0.05, 0.5, and 5.0 mg/kg/day for 4 weeks. …”

Phylodynamics of HIV-1 from a Phase III AIDS Vaccine Trial in Bangkok, Thailand by Marcos Pérez-Losada (159353)

“…Here, we used these data in combination with other publicly available gp120 sequences to perform a molecular surveillance and phylodynamic analysis of HIV-1 in Thailand.…”

CADA selectively and reversibly down-modulates human CD4 in a dose-dependent way. by Kurt Vermeire (12563)

“…(H) Kinetics of CD4 down-modulation showing a slow but steady removal of surface CD4 with CADA, and a fast but transient decrease in CD4 with PMA. …”

Ultralow Lattice Thermal Conductivity in the Aikinite Structure Family, Cu_<i>x</i>Pb_<i>x</i>Bi_2–<i>x</i>S₃, and Thermoelectric Propertie... by Srikanth Balijapelly (8974346)

“…All the compounds exhibit a narrow band gap below 1.0 eV confirmed by diffuse reflectance spectroscopy. …”

Evaluation of the Association between the AC3 Genetic Polymorphisms and Obesity in a Chinese Han Population by Hairu Wang (238131)

“…A total of 2580 adults, including 1490 lean (BMI = 18.5–23.9), 677 overweight (BMI 24.0–27.9) and 413 obese (BMI ≥28.0) subjects were genotyped for 5 TagSNPs in the AC3 gene. …”

Mendelian randomization results of MR-Egger. by Haitao Li (305080)

“…A fixed-effects meta-analysis confirmed that β-carotene (OR = 0.862, p = 2.21 × 10⁻⁶) and γ-tocopherol (OR = 0.701, p = 2.31 × 10⁻²) could decrease the risk of osteoporosis. To reduce exclusion limit bias, we used total body bone mineral density, lumbar spine bone mineral density and femoral neck bone mineral density as surrogates and found that the genetically elevated circulating β-carotene level could increase total body BMD (beta = 0.043, p-value = 8.26 x 10⁻⁵, power = 100%), lumbar spine BMD (beta = 0.226, p-value = 0.001, power = 100%) and femoral neck BMD(beta = 0.118, p-value = 0.016, power = 100%).…”

Simvastatin and Benznidazole-Mediated Prevention of <i>Trypanosoma cruzi</i>-Induced Endothelial Activation: Role of 15-epi-lipoxin A4 in the Action of Simvastatin by Carolina Campos-Estrada (403914)

“…Herein, we propose modifying endothelial activation with simvastatin or benznidazole and evaluate the pathways involved, including induction of 15-epi-LXA4. …”

Effects of pressure support and pressure-controlled ventilation on lung damage in a model of mild extrapulmonary acute lung injury with intra-abdominal hypertension by Cintia L. Santos (4047562)

“…They were then further randomized into subgroups without or with IAH (15 mmHg) and ventilated with PCV or PSV (PEEP = 5cmH₂O, driving pressure adjusted to achieve tidal volume = 6mL/kg) for 1h. …”

Usage of a Localised Microflow Device to Show that Mitochondrial Networks Are Not Extensive in Skeletal Muscle Fibres by Joseph Bruton (635407)

“…Cytosolic free [Ca²⁺] was monitored with fluo-3. A pulse of carbonyl cyanide 4-(trifluoromethoxy) phenylhydrazone (FCCP, 100 µM) applied to a small area of the muscle fibre (30 µm in diameter) produced a rapid decrease in the mitochondrial TMRE signal (indicative of depolarization) to 38% of its initial value. …”

Human pancreatic islet transplantation: an update and description of the establishment of a pancreatic islet isolation laboratory by Jakeline Rheinheimer (776186)

“…Recently, data published by the Collaborative Islet Transplant Registry (CITR) has revealed that approximately 50% of the patients who undergo islet transplantation are insulin independent after a 3-year follow-up. …”

Table_1_Cerebrovascular Disease and Perioperative Neurologic Vulnerability: A Prospective Cohort Study.DOCX by Phillip E. Vlisides (6740489)

“…</p><p>Results: Cerebral desaturation events (an oximetry decrease ≥20% from baseline or <50% absolute value for ≥3 min) occurred in 7/24 (29%) cerebrovascular disease patients and 2/24 (8.3%) controls (relative risk 3.5, 95% CI 0.81–15.2; P = 0.094). …”

Table_2_Cerebrovascular Disease and Perioperative Neurologic Vulnerability: A Prospective Cohort Study.DOCX by Phillip E. Vlisides (6740489)

“…</p><p>Results: Cerebral desaturation events (an oximetry decrease ≥20% from baseline or <50% absolute value for ≥3 min) occurred in 7/24 (29%) cerebrovascular disease patients and 2/24 (8.3%) controls (relative risk 3.5, 95% CI 0.81–15.2; P = 0.094). …”

Image_1_Cerebrovascular Disease and Perioperative Neurologic Vulnerability: A Prospective Cohort Study.pdf by Phillip E. Vlisides (6740489)

“…</p><p>Results: Cerebral desaturation events (an oximetry decrease ≥20% from baseline or <50% absolute value for ≥3 min) occurred in 7/24 (29%) cerebrovascular disease patients and 2/24 (8.3%) controls (relative risk 3.5, 95% CI 0.81–15.2; P = 0.094). …”

Operationalising Factors That Explain the Emergence of Infectious Diseases: A Case Study of the Human Campylobacteriosis Epidemic by Norval J. C. Strachan (235193)

“…The study focused on Scotland between 1990–2012 where there was a 75% increase in reported cases that included >300% increase in the elderly and 50% decrease in young children. …”

Table_4_Cerebrovascular Disease and Perioperative Neurologic Vulnerability: A Prospective Cohort Study.DOCX by Phillip E. Vlisides (6740489)

“…</p><p>Results: Cerebral desaturation events (an oximetry decrease ≥20% from baseline or <50% absolute value for ≥3 min) occurred in 7/24 (29%) cerebrovascular disease patients and 2/24 (8.3%) controls (relative risk 3.5, 95% CI 0.81–15.2; P = 0.094). …”

Table_3_Cerebrovascular Disease and Perioperative Neurologic Vulnerability: A Prospective Cohort Study.DOCX by Phillip E. Vlisides (6740489)

“…</p><p>Results: Cerebral desaturation events (an oximetry decrease ≥20% from baseline or <50% absolute value for ≥3 min) occurred in 7/24 (29%) cerebrovascular disease patients and 2/24 (8.3%) controls (relative risk 3.5, 95% CI 0.81–15.2; P = 0.094). …”

Analysis of BCL11A gene polymorphisms and hemolysis parameters in patients with sickle-cell disease by Marilia R. Laurentino (5629814)

“…The use of HU at doses ≥ 10 mg/kg/day showed a decrease of LDH (p = 0.02), and treatment for > 50 months was linked to the reticulocyte count (p = 0.0155). …”

Table_5_Cerebrovascular Disease and Perioperative Neurologic Vulnerability: A Prospective Cohort Study.DOCX by Phillip E. Vlisides (6740489)

“…</p><p>Results: Cerebral desaturation events (an oximetry decrease ≥20% from baseline or <50% absolute value for ≥3 min) occurred in 7/24 (29%) cerebrovascular disease patients and 2/24 (8.3%) controls (relative risk 3.5, 95% CI 0.81–15.2; P = 0.094). …”

Vitamin E for prevention of oxaliplatin-induced peripheral neuropathy: a pilot randomized clinical trial by Samuel Oliveira de Afonseca (12798419)

“…Previous studies have shown that vitamin E can reduce the incidence of peripheral neuropathy by 50%. This study aimed to assess the effectiveness of vitamin E for prevention of oxaliplatin-induced peripheral neuropathy.DESIGN AND SETTINGProspective, phase II, randomized pilot study developed at a university hospital in the Greater ABC region.METHODSPatients were randomized five days before starting oxaliplatin treatment, to receive either vitamin E or placebo until the end of the chemotherapy regimen. …”

Rab7A depletion affects Env processing and the incorporation of mature Env into viral particles. by Marina Caillet (198168)

“…This experiment is representative of 3 independent experiments done in duplicate. (<b>A</b>) Equal amounts of cell lysate (50 µg protein) were loaded to visualize the intracellular accumulation of viral proteins in Rab7A-depleted cells. …”