Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms by Farman M. Abbasi (22318766)

“…Current treatments, such as teriparatide, boost bone formation but also elevate resorption, limiting their long-term effectiveness. We discovered 3-butyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-<i>d</i>]pyrimidin-4(3<i>H</i>)-one <b>(5cc)</b>, an orally active phosphodiesterase-1 (PDE1) inhibitor aimed at restoring this balance. …”

Discovery of an Orally Active PDE1 Inhibitor for Disease-Modifying Treatment of Postmenopausal Osteoporosis via Dual Anabolic-Antiresorptive Mechanisms by Farman M. Abbasi (22318766)

“…Current treatments, such as teriparatide, boost bone formation but also elevate resorption, limiting their long-term effectiveness. We discovered 3-butyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-<i>d</i>]pyrimidin-4(3<i>H</i>)-one <b>(5cc)</b>, an orally active phosphodiesterase-1 (PDE1) inhibitor aimed at restoring this balance. …”

Initial treatment regimen. by Shivani Patel (4742748)

“…We reviewed the charts of adult patients diagnosed with locally advanced or metastatic BCC treated with vismodegib or sonidegib primarily for progression-free survival (PFS). …”

Patients baseline characteristics. by Shivani Patel (4742748)

“…We reviewed the charts of adult patients diagnosed with locally advanced or metastatic BCC treated with vismodegib or sonidegib primarily for progression-free survival (PFS). …”

Charge-Transfer-Driven Electrical Conductivity in Single Crystals of Assembled Triphenylamine Bis-urea Macrocycles by Fahidat A. Gbadamosi (22123930)

“…By encapsulating guests with varying reduction potentials, including 2,5-dichloro-1,4-benzoquinone (ClBQ), 2,1,3-benzothiadiazole (BTD), and malononitrile (MN), we observed significant changes in the electrical conductivity. …”

Charge-Transfer-Driven Electrical Conductivity in Single Crystals of Assembled Triphenylamine Bis-urea Macrocycles by Fahidat A. Gbadamosi (22123930)

“…By encapsulating guests with varying reduction potentials, including 2,5-dichloro-1,4-benzoquinone (ClBQ), 2,1,3-benzothiadiazole (BTD), and malononitrile (MN), we observed significant changes in the electrical conductivity. …”

Charge-Transfer-Driven Electrical Conductivity in Single Crystals of Assembled Triphenylamine Bis-urea Macrocycles by Fahidat A. Gbadamosi (22123930)

“…By encapsulating guests with varying reduction potentials, including 2,5-dichloro-1,4-benzoquinone (ClBQ), 2,1,3-benzothiadiazole (BTD), and malononitrile (MN), we observed significant changes in the electrical conductivity. …”

Overall survival. by Shivani Patel (4742748)

“…We reviewed the charts of adult patients diagnosed with locally advanced or metastatic BCC treated with vismodegib or sonidegib primarily for progression-free survival (PFS). …”

Charge-Transfer-Driven Electrical Conductivity in Single Crystals of Assembled Triphenylamine Bis-urea Macrocycles by Fahidat A. Gbadamosi (22123930)

“…By encapsulating guests with varying reduction potentials, including 2,5-dichloro-1,4-benzoquinone (ClBQ), 2,1,3-benzothiadiazole (BTD), and malononitrile (MN), we observed significant changes in the electrical conductivity. …”

CHWs house visits. by Nicole Michelén Ströfer (19269154)

“…The performance of the malaria CHW network was evaluated using weekly data collected from CHWs and routinely collected surveillance data from the Ministry of Public Health (MoH). We assess performance of CHWs by analyzing key variables including (1) reporting compliance, (2) household visitation rates, (3) malaria rapid diagnostic tests performed, (4) malaria cases detected, and (5) time between symptom onset and malaria diagnosis. …”

Progression-free survival by treatment. by Shivani Patel (4742748)

“…We reviewed the charts of adult patients diagnosed with locally advanced or metastatic BCC treated with vismodegib or sonidegib primarily for progression-free survival (PFS). …”

Charge-Transfer-Driven Electrical Conductivity in Single Crystals of Assembled Triphenylamine Bis-urea Macrocycles by Fahidat A. Gbadamosi (22123930)

“…By encapsulating guests with varying reduction potentials, including 2,5-dichloro-1,4-benzoquinone (ClBQ), 2,1,3-benzothiadiazole (BTD), and malononitrile (MN), we observed significant changes in the electrical conductivity. …”

Maintenance regimen and adverse event management. by Shivani Patel (4742748)

“…We reviewed the charts of adult patients diagnosed with locally advanced or metastatic BCC treated with vismodegib or sonidegib primarily for progression-free survival (PFS). …”

Charge-Transfer-Driven Electrical Conductivity in Single Crystals of Assembled Triphenylamine Bis-urea Macrocycles by Fahidat A. Gbadamosi (22123930)

“…By encapsulating guests with varying reduction potentials, including 2,5-dichloro-1,4-benzoquinone (ClBQ), 2,1,3-benzothiadiazole (BTD), and malononitrile (MN), we observed significant changes in the electrical conductivity. …”

BCC-specific survival. by Shivani Patel (4742748)

“…We reviewed the charts of adult patients diagnosed with locally advanced or metastatic BCC treated with vismodegib or sonidegib primarily for progression-free survival (PFS). …”

Optical coherence tomography findings. by Eisuke Usui (12111855)

“…After PCI, hDPV significantly increased from 55.6 cm/s to 69.5 cm/s (P<0.01), with a median %hDPV increase of 27.2 (6.32–59.1) %, while %hDPV decreased in 20 (19.4%) patients. …”

S1 Data - by Eisuke Usui (12111855)

“…After PCI, hDPV significantly increased from 55.6 cm/s to 69.5 cm/s (P<0.01), with a median %hDPV increase of 27.2 (6.32–59.1) %, while %hDPV decreased in 20 (19.4%) patients. …”

Clinical demographics and angiographic findings. by Eisuke Usui (12111855)

“…After PCI, hDPV significantly increased from 55.6 cm/s to 69.5 cm/s (P<0.01), with a median %hDPV increase of 27.2 (6.32–59.1) %, while %hDPV decreased in 20 (19.4%) patients. …”

Physiological parameters. by Eisuke Usui (12111855)

“…After PCI, hDPV significantly increased from 55.6 cm/s to 69.5 cm/s (P<0.01), with a median %hDPV increase of 27.2 (6.32–59.1) %, while %hDPV decreased in 20 (19.4%) patients. …”

DataSheet_1_Gonadal androgens are associated with decreased type I interferon production by plasmacytoid dendritic cells and increased IgG titres to BNT162b2 following co-vaccinati... by Oliver L. Sampson (18067186)