AZD1775 induces toxicity through double-stranded DNA breaks independently of chemotherapeutic agents in p53-mutated colorectal cancer cells by Peter John Webster (3838426)

“…AZD1775 significantly improved the cytotoxicity of 5-FU in a p53-mutated colorectal cancer cell line (HT29 cells), decreasing the IC₅₀ from 9.3 μM to 3.5 μM. …”

Effectiveness of all intervention scenarios. by Yae Jee Baek (9565342)

“…We assume the sensitivity of front door screening of 0.5 or 0.7 and the protection rates possibly becoming 0.3, 0.6, or 0.9 as reinforcing protection device. …”

Effectiveness of all intervention scenarios. by Yae Jee Baek (9565342)

“…We assume the sensitivity of front door screening of 0.5 or 0.7 and the protection rates possibly becoming 0.3, 0.6, or 0.9 as reinforcing protection device. …”

PIN1 endocytosis is inhibited in the lobe region by the ROP2 pathway in PCs. by Shingo Nagawa (173932)

“…Coexpressing CA-ROP2 suppressed both vesicle formation and decrease of PM signal in <i>rop4 R2i</i> cells (<i>n</i> = 5). …”

Data_Sheet_1_Identification of novel small molecule inhibitors of twin arginine translocation (Tat) pathway and their effect on the control of Campylobacter jejuni in chickens.pdf by Loïc Deblais (5620073)

“…</p>Results<p>Furthermore, we evaluated 177 SM hits (2.5 μg/mL and above) that increased the susceptibility to CuSO₄ for the inhibition of formate dehydrogenase (Fdh) activity, a Tat-dependent substrate. …”

Effect of siRNA specific for PIASy and E12 in α-SMA regulation in MCs. by Kazuo Torikoshi (150022)

“…<p>(A) PIASy mRNA and protein were reduced by transfection of siRNA against PIASy in mouse MCs. …”

Exploring Harsh Parenting and Accuracy of Social Judgement Through the Hidden Talents Framework by Jack Chen (21781097)

Mutations at p53 binding sites augment PIK3CA promoter activity. by Snehal M. Gaikwad (279479)

“…Representative bioluminescent images of the mice bearing tumors of A2780-MPFT3 cells. Mouse from control and treated group exhibited specific [Fig. 5e3 (pre-treatment)] signals which did not decrease even after two treatments of cisplatin [Fig. 5e3 (post-treatment)].…”

Effect of the measurement of the work of breathing on the respiratory outcome of preterms by Benjamin Dudoignon (11051311)

Tie2 mRNA and protein expression in control and <i>Tie2</i> knockout mice. by Peter J. Zwiers (7510744)

Modulating the excitability gradient changes domino speed. by Jennifer Creaser (9427932)

“…Scale bar: 500 <i>μ</i>V, 5s. Panel <b>c</b> shows the mean recruitment time of model simulations of the network with different values of excitability gradient <i>δν</i>. …”

Schematic of experimental paradigms. by Shiva Farashahi (5018381)

“…A central yellow bar represented the probability of reward (between 0.5 and 1.0), while the peripheral arc indicated the amount of reward. …”

Study on the properties of oil-water interface after the interaction between ionized water and naphthenic acid by Qin Guowei (22155073)

“…The results show that after the action, the interfacial tension of oil and water continues to decrease, and 1/3 ionized water (salinity diluted to 1/3 of the prepared ionized water, 1253 ppm) decreases to a maximum of 50.89%, while 1/5 ionized water (752 ppm) only decreases 14.40%; the thickness of the oil-water interface film decreases with the salinity of ionized water, but the decrease increases after 1/3 ionized water. …”

Zebrafish TMEM33 attenuates MAVS-induced cellular antiviral function. by Long-Feng Lu (6528632)

“…<p>(A and B) Overexpression of TMEM33 restores MAVS-mediated decrease of viral titer. …”

Synthesis and Activity of Ruthenium Olefin Metathesis Catalysts Coordinated with Thiazol-2-ylidene Ligands by Georgios C. Vougioukalakis (2290621)

“…In the solid state, the aryl substituents of the thiazole-2-ylidene ligands are located above the empty coordination site of the ruthenium center. Despite the decreased steric bulk of their ligands, all of the complexes reported herein efficiently promote benchmark olefin metathesis reactions such as the ring-closing of diethyldiallyl and diethylallylmethallyl malonate and the ring-opening metathesis polymerization of 1,5-cyclooctadiene and norbornene, as well as the cross metathesis of allyl benzene with <i>cis</i>-1,4-diacetoxy-2-butene and the macrocyclic ring-closing of a 14-membered lactone. …”

Synthesis and Activity of Ruthenium Olefin Metathesis Catalysts Coordinated with Thiazol-2-ylidene Ligands by Georgios C. Vougioukalakis (2290621)

“…In the solid state, the aryl substituents of the thiazole-2-ylidene ligands are located above the empty coordination site of the ruthenium center. Despite the decreased steric bulk of their ligands, all of the complexes reported herein efficiently promote benchmark olefin metathesis reactions such as the ring-closing of diethyldiallyl and diethylallylmethallyl malonate and the ring-opening metathesis polymerization of 1,5-cyclooctadiene and norbornene, as well as the cross metathesis of allyl benzene with <i>cis</i>-1,4-diacetoxy-2-butene and the macrocyclic ring-closing of a 14-membered lactone. …”

Synthesis and Activity of Ruthenium Olefin Metathesis Catalysts Coordinated with Thiazol-2-ylidene Ligands by Georgios C. Vougioukalakis (2290621)

“…In the solid state, the aryl substituents of the thiazole-2-ylidene ligands are located above the empty coordination site of the ruthenium center. Despite the decreased steric bulk of their ligands, all of the complexes reported herein efficiently promote benchmark olefin metathesis reactions such as the ring-closing of diethyldiallyl and diethylallylmethallyl malonate and the ring-opening metathesis polymerization of 1,5-cyclooctadiene and norbornene, as well as the cross metathesis of allyl benzene with <i>cis</i>-1,4-diacetoxy-2-butene and the macrocyclic ring-closing of a 14-membered lactone. …”

Synthesis and Activity of Ruthenium Olefin Metathesis Catalysts Coordinated with Thiazol-2-ylidene Ligands by Georgios C. Vougioukalakis (2290621)

“…In the solid state, the aryl substituents of the thiazole-2-ylidene ligands are located above the empty coordination site of the ruthenium center. Despite the decreased steric bulk of their ligands, all of the complexes reported herein efficiently promote benchmark olefin metathesis reactions such as the ring-closing of diethyldiallyl and diethylallylmethallyl malonate and the ring-opening metathesis polymerization of 1,5-cyclooctadiene and norbornene, as well as the cross metathesis of allyl benzene with <i>cis</i>-1,4-diacetoxy-2-butene and the macrocyclic ring-closing of a 14-membered lactone. …”

Empagliflozin Reduces Liver Fat in Diabetic and Nondiabetic Subjects by Siham Abdelgani (17756772)

Localisation and quantification of NL2 immunoreactivity within the hippocampus of WT and dystrophin-deficient mice, reacted and imaged under identical conditions. by Elżbieta Krasowska (635317)

“…Scale bars (A1, B1, C1) 50 µm; (A2, B2, C2) 10 µm; (A3, B3, C3) 5 µm.…”