Table_1_Necrostatin-1 Attenuates Trauma-Induced Mouse Osteoarthritis and IL-1β Induced Apoptosis via HMGB1/TLR4/SDF-1 in Primary Mouse Chondrocytes.DOCX by Shuang Liang (211832)

“…<p>Necrostatin-1 (Nec-1) is a specific small molecule inhibitor of receptor-interacting protein kinase 1 (RIPK1) that specifically inhibits phosphorylation of RIPK1. …”

Immuno-Regulatory Function of Indoleamine 2,3 Dioxygenase through Modulation of Innate Immune Responses by Malihe-Sadat Poormasjedi-Meibod (441343)

“…Local IDO significantly decreased the number of infiltrating macrophages (11±1.47 vs. 70.5±7.57 cells/HPF), T-cells (8.75±1.03 vs. 75.75±5.72 cells/HPF) and iNOS expression in IDO-expressing xenografts versus controls. …”

DataSheet_1_High expression of RARG accelerates ovarian cancer progression by regulating cell proliferation.zip by Lin Xiu (11085656)

“…The area under the curve (AUC) of RAGR expression for predicting patient survival rates at 1, 5 and 9 years were 0.659, 0.616 and 0.627, respectively. …”

Image_6_Autophagy-Related LC3 Accumulation Interacted Directly With LIR Containing RIPK1 and RIPK3, Stimulating Necroptosis in Hypoxic Cardiomyocytes.TIF by Yao Huang (216100)

“…Conversely, after alleviating hypoxia-induced autophagic flux impairment with LC3 or ATG5 knockdown adenovirus, the effects of hypoxia on RIPK1 and RIPK3 levels were reduced, which resulted in decreased p-RIPK3 and p-MLKL. …”

Is the risk of progressive multifocal leukoencephalopathy the real reason for natalizumab discontinuation in patients with multiple sclerosis? by Julia Krämer (436881)

“…Despite introduction of the currently employed PML risk stratification algorithm, the incidence of natalizumab-associated PML cases is not decreasing.</p><p>Objectives</p><p>We addressed the following questions: How do natalizumab-treated multiple sclerosis patients and their treating physicians assess and deal with PML risk? …”

Image_2_Autophagy-Related LC3 Accumulation Interacted Directly With LIR Containing RIPK1 and RIPK3, Stimulating Necroptosis in Hypoxic Cardiomyocytes.TIF by Yao Huang (216100)

“…Conversely, after alleviating hypoxia-induced autophagic flux impairment with LC3 or ATG5 knockdown adenovirus, the effects of hypoxia on RIPK1 and RIPK3 levels were reduced, which resulted in decreased p-RIPK3 and p-MLKL. …”

TNKS expression is required for TNKSi-dependent assembly of axin puncta. by Estefania Martino-Echarri (2548186)

“…Only small differences were observed after knockdown of the individual TNKS. <b>D.</b> A more detailed comparison of the impact of TNKS expression on puncta was performed by scoring the range of puncta present per cell (categories: <5, 5–15 or >15 puncta). …”

PGRN knockdown results in reduced motor axon outgrowth. by Angela S. Laird (360986)

“…<p>A) Knockdown of <i>grna</i>, by morpholino targeted to both the start codon (ATG) and 5′UTR region of zebrafish PGRN sequence, produced a dose dependent decrease in axonal length compared to mismatch Control MO injected embryos.…”

Peptide interactions with di-8-ANEPPS labeled LUV and cell membranes. by Axel Hollmann (397503)

“…Dashed curves represent the fitting to the single binding site equation (eq. 5). Affinity parameters for the cells are indicated in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0060302#pone-0060302-t003" target="_blank">Table 3</a>. …”

CD4 T cell dependence of vaccine-induced protection against <i>G</i>. <i>lamblia</i>. by Sozaburo Ihara (4967050)

“…Data are compiled from two separate experiments, with mean day 5 log₁₀ trophozoite loads in the CTX controls of 6.87 and 7.31 (A, WT mice), 6.53 and 5.06 (A, CD4 KO), and 7.20 and 6.99 (B, Rag-2 KO). …”

Data Sheet 1_Amyloid-induced mitochondrial network disruption in neurons monitored by STED super-resolution imaging.pdf by Iuliia Golovynska (18880049)

“…As a result, the volume and surface area per mitochondrion decrease by 6-fold and 4-fold, respectively. …”

Summary of responses to free-flight antennal stimulation of extrinsic antennal muscles in six animals. by Armin J. Hinterwirth (109677)

“…In most cases, stimulation is associated with a decrease in ground speed. In cells labeled “n.a.”, parameters could not be computed because a full 3D path was impossible to reconstruct.…”

The cytoplasmic and extracellular domains are required for Sdc function. by Margaret U. Nguyen (3177789)

“…(C) Sdc mutants had a significant decrease in boutons per NMJ as described previously [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0151621#pone.0151621.ref005" target="_blank">5</a>]. …”

Interaction between SSVEP power and alpha power and the proposed mechanism of interaction. by Liyu Cao (786645)

“…Consequently, SSVEP and behavioural detection rate (both exclusively probed and introduced in the central part of the visual field marked by the black circle) will decrease. The original data are available from <a href="https://doi.org/10.6084/m9.figshare.9094742.v1" target="_blank">https://doi.org/10.6084/m9.figshare.9094742.v1</a>. …”

Extreme Evolutionary Disparities Seen in Positive Selection across Seven Complex Diseases by Erik Corona (171556)

“…We take a large set of the most strongly associated SNPs in each GWA study in order to capture more hidden associations at the cost of introducing false positives into our analysis. …”

Microgel-Based Stretchable Reservoir Devices for Elongation Enhanced Small Molecule Release Rate by Yingnan Zhang (270437)

“…Stretchable poly­(<i>N</i>-isopropylacrylamide)-<i>co</i>-acrylic acid (pNIPAm-<i>co</i>-10% AAc) microgel-based reservoir devices were fabricated and used to control the release rate of the small molecule model drug tris­(4-(dimethylamino)­phenyl)­methylium chloride (crystal violet, CV) to solution by varying the Au layer thickness coating the microgels and device elongation. Specifically, we showed that CV could be loaded into the microgel layer of the devices via electrostatic interactions at pH 6.5, and the release could be triggered upon exposure to a pH 3.0 solution, which breaks the microgel–CV electrostatic interactions. …”

Real-Time Changes in Corticospinal Excitability during Voluntary Contraction with Concurrent Electrical Stimulation by Tomofumi Yamaguchi (131732)

“…We monitored motor evoked potentials (MEPs) elicited by transcranial magnetic stimulation and recorded the MEPs using a mechanomyogram, which is less susceptible to electrical artifacts. …”

Microgel-Based Stretchable Reservoir Devices for Elongation Enhanced Small Molecule Release Rate by Yingnan Zhang (270437)

“…Stretchable poly­(<i>N</i>-isopropylacrylamide)-<i>co</i>-acrylic acid (pNIPAm-<i>co</i>-10% AAc) microgel-based reservoir devices were fabricated and used to control the release rate of the small molecule model drug tris­(4-(dimethylamino)­phenyl)­methylium chloride (crystal violet, CV) to solution by varying the Au layer thickness coating the microgels and device elongation. Specifically, we showed that CV could be loaded into the microgel layer of the devices via electrostatic interactions at pH 6.5, and the release could be triggered upon exposure to a pH 3.0 solution, which breaks the microgel–CV electrostatic interactions. …”

Effect of BCAS on myelin and inflammation in subcortical and cortical tissue. by Yun-An Lim (337762)

“…<p>(A-G) Analysis of the subcortical region. (A) Representative immunoblots of subcortical region 15D post BCAS (S = Sham, B+V = BCAS+Veh, B+A = BCAS+Ac-YVAD-cmk). …”

<em>Nigella sativa</em> (Black Cumin) Seed Extract Alleviates Symptoms of Allergic Diarrhea in Mice, Involving Opioid Receptors by Swantje C. Duncker (154707)

“…DAMGO, in contrast, had no effect on mast cell parameters but decreased IFNγ, IL-4, IL-5, and IL-10 concentration after <em>ex vivo</em> re-stimulation of mesenteric lymphocytes. …”