Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Targeting P-glycoprotein (ABCB1 or P-gp) has been recognized as a promising strategy to overcome multidrug resistance. Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Targeting P-glycoprotein (ABCB1 or P-gp) has been recognized as a promising strategy to overcome multidrug resistance. Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

APAP bioactivation is decreased in fructose-fed mice. by Sungjoon Cho (4385851)

In we present the number of modules determined by DMSP on various values of connectivity density by Ioannis A Maraziotis (86282)

“…In figure we display the initial size of the kernel, as well as the final size of the module, for modules with various sizes, and densities above 0.5. …”

Data_Sheet_1_Can multi-cropping affect soil microbial stoichiometry and functional diversity, decreasing potential soil-borne pathogens? A study on European organic vegetable cropp... by Alessandra Trinchera (10984554)

A Novel Primary Porcine Retinal Pigment Epithelium Cell Model with Preserved Properties by Dinna Zhou (17007894)

“…The RPE characteristics decreased and disappeared with transdifferentiation.…”

Average negative, positive, and net work data for all the walking conditions: Level (0°), downhill (−5°,−10°), and uphill (+5°,+10°) (n = 12). by Nikolaos Papachatzis (12959894)

“…During uphill walking, the knee increased the magnitude of net positive work (0° vs. 10°: p = 0.005; +5° vs. +10°: p = 0.012). <b>(D)</b> The hip increased the magnitude of the net negative work when the slope of walking decreased (0° vs. −5°: p = 0.002; −0° vs. −10°: p = 0.002), while uphill walking shifted and increased the hip’s net mechanical behavior (0° vs. +5°: p = 0.002; 0° vs +10°: p = 0.002; +5° vs. +10°: p = 0.002). …”

Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)‑<i>s</i>‑triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades by Ihab Shawish (13015516)

“…Compound <b>4f</b> exhibited potent EGFR inhibitory activity with an IC₅₀ value of 61 nM compared to that of Tamoxifen (IC₅₀ value of 69 nM), with EGFR inhibition of 83 and 84%, respectively, at a concentration of 10 μM. Interestingly, <b>4f</b> showed remarkable PI3K/AKT/mTOR inhibitory activity with 0.18-, 0.27-, and 0.39-fold decrease in their concentration (reduction in controls from 6.64, 45.39, and 86.39 ng/mL to 1.24, 12.35, and 34.36 ng/mL, respectively). …”

Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)‑<i>s</i>‑triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades by Ihab Shawish (13015516)

“…Compound <b>4f</b> exhibited potent EGFR inhibitory activity with an IC₅₀ value of 61 nM compared to that of Tamoxifen (IC₅₀ value of 69 nM), with EGFR inhibition of 83 and 84%, respectively, at a concentration of 10 μM. Interestingly, <b>4f</b> showed remarkable PI3K/AKT/mTOR inhibitory activity with 0.18-, 0.27-, and 0.39-fold decrease in their concentration (reduction in controls from 6.64, 45.39, and 86.39 ng/mL to 1.24, 12.35, and 34.36 ng/mL, respectively). …”

Nectin-1 staining is decreased in HSV1-infected keratinocytes, but enhanced as a collar in surrounding uninfected cells. by Hafsa Rana (8201886)

Decreased by Violet R. Mukaro (282939)

Table 1_Effect of decreased suspended sediment content on chlorophyll-a in Dongting Lake, China.docx by Le Zhang (88249)

Toroidal metamaterials. by Wen-Ying Zhou (10049543)

“…Initially, we employ COMSOL software to design a MIMO mobile terminal antenna that meets 2G, 3G, 4G, and 5G communication requirements. …”

Human tissue dielectric parameters. by Wen-Ying Zhou (10049543)

“…Initially, we employ COMSOL software to design a MIMO mobile terminal antenna that meets 2G, 3G, 4G, and 5G communication requirements. …”

Human head modeling. by Wen-Ying Zhou (10049543)

“…Initially, we employ COMSOL software to design a MIMO mobile terminal antenna that meets 2G, 3G, 4G, and 5G communication requirements. …”

Variations in SAR for individual organizations. by Wen-Ying Zhou (10049543)

“…Initially, we employ COMSOL software to design a MIMO mobile terminal antenna that meets 2G, 3G, 4G, and 5G communication requirements. …”

Optical Effects of <i>S</i>-Oxidation and M^<i>n</i>+ Binding in <i>meso</i>-Thienyl Dipyrrin Systems and of Stepwise Bromination of 4,4-Difluoro-8-(2,5-dibromo-3-thienyl... by Shin Hei Choi (2190841)

“…We report 16 novel species and 8 molecular structures in studying how <i>meso</i>-thienyl-substituted dipyrrole oxidation, bromination, and metal ion binding impart optical changes, as monitored by UV−vis absorption/emission spectroscopy. …”

Optical Effects of <i>S</i>-Oxidation and M^<i>n</i>+ Binding in <i>meso</i>-Thienyl Dipyrrin Systems and of Stepwise Bromination of 4,4-Difluoro-8-(2,5-dibromo-3-thienyl... by Shin Hei Choi (2190841)

“…We report 16 novel species and 8 molecular structures in studying how <i>meso</i>-thienyl-substituted dipyrrole oxidation, bromination, and metal ion binding impart optical changes, as monitored by UV−vis absorption/emission spectroscopy. …”

Optical Effects of <i>S</i>-Oxidation and M^<i>n</i>+ Binding in <i>meso</i>-Thienyl Dipyrrin Systems and of Stepwise Bromination of 4,4-Difluoro-8-(2,5-dibromo-3-thienyl... by Shin Hei Choi (2190841)

“…We report 16 novel species and 8 molecular structures in studying how <i>meso</i>-thienyl-substituted dipyrrole oxidation, bromination, and metal ion binding impart optical changes, as monitored by UV−vis absorption/emission spectroscopy. …”

Optical Effects of <i>S</i>-Oxidation and M^<i>n</i>+ Binding in <i>meso</i>-Thienyl Dipyrrin Systems and of Stepwise Bromination of 4,4-Difluoro-8-(2,5-dibromo-3-thienyl... by Shin Hei Choi (2190841)

“…We report 16 novel species and 8 molecular structures in studying how <i>meso</i>-thienyl-substituted dipyrrole oxidation, bromination, and metal ion binding impart optical changes, as monitored by UV−vis absorption/emission spectroscopy. …”