Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study by Paul S. de Vries (701679)

“…When using a stricter Bonferroni correction for the 1000G GWA study (<i>P</i>-value < 2.5×10⁻⁸), the number of loci significant only using HapMap imputation increased to 4 while the number of loci significant only using 1000G decreased to 5. …”

Dose-dependent effects of NE/IFN-γ on the proliferation and invasion of PC cells. by Liancai Wang (306725)

“…A β₂-AR antagonist decreased the stimulatory effects of NE (10⁻⁸ M) but did not alter the suppressive effects of NE (10⁻⁶ M) (E and F). (* Significant difference with control group, <i>P</i><0.05).…”

Representative images of DEP (10 µg/ml) -treated HAECs (fixed cells) in PBS obtained by the coupled AF/FL microscope. by Yangzhe Wu (162008)

“…Optical images were obtained using a 100× oil objective. The exposure time of DEPs is marked on respective optical images. …”

The location of action potential initiation and the magnetic threshold depend on the location of the soma relative to the coil. by Tamar Pashut (354298)

“…<b>B</b>, The magnetic threshold decreased with Δx until it reached a minimum at the location corresponding to the maximal gradient of the electric field. …”

Morphological changes in the hindbrains of <i>Bmpr</i> knockout mutants. by Lihua Qin (494786)

“…(A, B) H&E staining shows that the pontine gray nucleus was dramatically decreased in the <i>Bmpr</i> double knockout mutant (B, arrow) compared to normal (A, arrow). …”

Simulating the maximum BOLD signal through dHb elimination. by Valerie E. M. Griffeth (278482)

“…Three mechanisms of dHb reduction are included: hyperoxia combined with CBF increase (blue), CBF increase only (green) and CMRO₂ cessation (red). Also included is a simulation for ΔCBF = 100% and PaO₂ = 390 mmHg consistent with findings from Gauthier et al. …”

lncCyt b cooperates with hnRNPA2B1 to modulate glycolysis and exhibits physiological significance. by Jia Li (160557)

“…(E) CCK-8 assays showing the decreased proliferation of A549 cells by lncCyt b or hnRNPA2B1 knockdown. …”

Data_Sheet_1_Ecologically different earthworm species are the driving force of microbial hotspots influencing Pb uptake by the leafy vegetable Brassica campestris.pdf by Cevin Tibihenda (17090521)

“…A significant shift in the bacterial community was observed in the treatments with E. fetida inoculation at 500 and 1,000 mg·kg⁻¹ Pb, where the G⁺/G⁻ bacteria ratio was significantly decreased compared to no earthworm inoculation. …”

Regulation of <i>ryhB1</i> and <i>ryhB2</i> by σ^S in <i>Salmonella</i>. by Selma Metaane (12329248)

“…Relative quantification of bands intensity (normalized to the 5S RNA) indicated that the Δ<i>rpoS</i> mutation decreased by about ten-fold the amounts of RyhB1 and RyhB2 detected in the wild-type strain, as previously reported [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0265511#pone.0265511.ref005" target="_blank">5</a>]. …”

The Expression of miR-375 Is Associated with Carcinogenesis in Three Subtypes of Lung Cancer by Yi Jin (38575)

“…Moreover, we performed dual luciferase reporter assay and Western blot on 6 targeted genes (<i>FZD8</i>, <i>ITGA10</i>, <i>ITPKB</i>, <i>LRP5</i>, <i>PIAS1</i> and<i>RUNX1</i>) in small cell lung carcinoma cell line NCI-H82. …”

DataSheet1_EPM2A acts as a protective factor in prostate cancer, evidence from a real-world patient cohort.docx by Qintao Ge (13817716)

“…The nomogram containing the EPM2A group, T stage and Gleason score showed a preferable prognostic value (AUC = 0.755; Hosmer‒Lemeshow, p = 0.486). In validation, we confirmed the lower transcript level of EPM2A in PCA than in normal tissues (120.5 ± 2.159 vs. 138.3 ± 1.83, p = 0.035) and correlated it with the expression level of PD-1 (R = 0.283). …”

DataSheet_1_Mechanism Study of the Protective Effects of Sodium Tanshinone IIA Sulfonate Against Atorvastatin-Induced Cerebral Hemorrhage in Zebrafish: Transcriptome Analysis.docx by Zhong-Yan Zhou (6592862)

“…In our previous study, we established a zebrafish model of cerebral hemorrhage and found that STS dramatically decreased both the hemorrhage rate and hemorrhage area, although the underlying mechanism was not fully elucidated. …”

Administration of antibiotics alleviated colonic inflammation, which was associated with suppressed tumorigenesis. by Jae Gon Lee (6645983)

“…<p>(A) Representative histological findings at the end of the experiment. …”

Heatmap of deviation from 1:1 segregation of homozygotes at various population sizes and selection strengths. by Alexander Coulton (8468724)

“…Each tile is an average value over 20 simulations with 20 markers at evenly spaced intervals, totalling 100 centimorgan. Deviation is calculated as ∑(<i>y</i> − 0.5)² where y is the ratio of homozygous genotypes at an arbitrary locus; a is the number of homozygous genotypes from parent 1, b is the number of homozygous genotypes from parent 2 at an arbitrary locus.…”

Outcome of environmental surveys by hospital ward. by Antonella Felice (6934226)

“…<p>Each survey with at least one positive sample was assigned a “positive” outcome and was further classified into low (100 ≤ CFUl⁻¹ ≤ 1,000), medium (1,000 ≤ CFUl⁻¹ ≤ 10,000) and high (>10,000 CFUl⁻¹) risk based on the highest contamination found. …”

Estimated median (and inter-quartile range) probability (%) of developing life-long immunity after HPV infection clearance by HPV type. by Iacopo Baussano (234638)

“…<div><p>As the probability decreases from 50% to 0%, HPV infections are increasingly more likely to be cleared without developing immunity, i.e. increasingly characterized by a predominant SIS clearance pattern. …”

Effect of azurin in FAK-Src signaling. by Nuno Bernardes (435240)

“…<p>Azurin at 50 µM and 100 µM decreased phosphorylation levels of FAK Y397 and Src Y416 in both MCF-7/AZ.Pcad and SUM149 breast cancer cells, but not Akt S473, in a dose-dependent manner. …”

Enhanced pyruvate dehydrogenase activity improves cardiac outcomes in a murine model of cardiac arrest by Lin Piao (4452487)

“…Compared to normothermic (37°C) CA controls, administering TH (30°C) improved overall survival (72-hour survival rate: 62.5% vs. 28.6%, <i>P</i><0.001), post-resuscitation myocardial function (ejection fraction: 50.9±3.1% vs. 27.2±2.0%, <i>P</i><0.001; aorta systolic pressure: 132.7±7.3 vs. 72.3±3.0 mmHg, <i>P</i><0.001), and neurological scores at 72-hour post CA (9.5±1.3 vs. 5.4±1.3, <i>P</i><0.05). …”

Data_Sheet_1_Non-invasive Vagus Nerve Stimulation for COVID-19: Results From a Randomized Controlled Trial (SAVIOR I).docx by Carlos Tornero (9946163)

“…Procalcitonin level also showed significantly greater decreases from baseline to day 5 in the nVNS group than in the SoC group. …”

Data Sheet 1_Sodium-glucose cotransporter 2 inhibitors—but not insulin—enhance renal branched-chain amino acid catabolism.docx by Moeko Sakamoto (22578098)

“…</p>Methods<p>We conducted a prospective, single-center, open-label, nonrandomized, controlled clinical study in patients with type 2 diabetes stably treated with insulin, who were assigned to dapagliflozin (5 mg/day with dose-reduced insulin; n=8/9 completed) or insulin dose-up (n=5/8 completed). …”