The cytoplasmic and extracellular domains are required for Sdc function. by Margaret U. Nguyen (3177789)

“…(C) Sdc mutants had a significant decrease in boutons per NMJ as described previously [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0151621#pone.0151621.ref005" target="_blank">5</a>]. …”

Extreme Evolutionary Disparities Seen in Positive Selection across Seven Complex Diseases by Erik Corona (171556)

“…We take a large set of the most strongly associated SNPs in each GWA study in order to capture more hidden associations at the cost of introducing false positives into our analysis. …”

Microgel-Based Stretchable Reservoir Devices for Elongation Enhanced Small Molecule Release Rate by Yingnan Zhang (270437)

“…Stretchable poly­(<i>N</i>-isopropylacrylamide)-<i>co</i>-acrylic acid (pNIPAm-<i>co</i>-10% AAc) microgel-based reservoir devices were fabricated and used to control the release rate of the small molecule model drug tris­(4-(dimethylamino)­phenyl)­methylium chloride (crystal violet, CV) to solution by varying the Au layer thickness coating the microgels and device elongation. Specifically, we showed that CV could be loaded into the microgel layer of the devices via electrostatic interactions at pH 6.5, and the release could be triggered upon exposure to a pH 3.0 solution, which breaks the microgel–CV electrostatic interactions. …”

Real-Time Changes in Corticospinal Excitability during Voluntary Contraction with Concurrent Electrical Stimulation by Tomofumi Yamaguchi (131732)

“…We monitored motor evoked potentials (MEPs) elicited by transcranial magnetic stimulation and recorded the MEPs using a mechanomyogram, which is less susceptible to electrical artifacts. …”

Microgel-Based Stretchable Reservoir Devices for Elongation Enhanced Small Molecule Release Rate by Yingnan Zhang (270437)

“…Stretchable poly­(<i>N</i>-isopropylacrylamide)-<i>co</i>-acrylic acid (pNIPAm-<i>co</i>-10% AAc) microgel-based reservoir devices were fabricated and used to control the release rate of the small molecule model drug tris­(4-(dimethylamino)­phenyl)­methylium chloride (crystal violet, CV) to solution by varying the Au layer thickness coating the microgels and device elongation. Specifically, we showed that CV could be loaded into the microgel layer of the devices via electrostatic interactions at pH 6.5, and the release could be triggered upon exposure to a pH 3.0 solution, which breaks the microgel–CV electrostatic interactions. …”

RHO-1 regulates fecundity. by Rachel McMullan (183027)

“…Expression of <i>hsRHO-1</i>(<i>G14V</i>) (<i>nzIs1</i>) or <i>nRHO-1</i>(<i>G14V</i>) (<i>nzIs29</i>) led to a significant decrease in the number of eggs remaining in animals when compared to wild type controls. …”

Effect of BCAS on myelin and inflammation in subcortical and cortical tissue. by Yun-An Lim (337762)

“…<p>(A-G) Analysis of the subcortical region. (A) Representative immunoblots of subcortical region 15D post BCAS (S = Sham, B+V = BCAS+Veh, B+A = BCAS+Ac-YVAD-cmk). …”

<em>Nigella sativa</em> (Black Cumin) Seed Extract Alleviates Symptoms of Allergic Diarrhea in Mice, Involving Opioid Receptors by Swantje C. Duncker (154707)

“…DAMGO, in contrast, had no effect on mast cell parameters but decreased IFNγ, IL-4, IL-5, and IL-10 concentration after <em>ex vivo</em> re-stimulation of mesenteric lymphocytes. …”

The GePPI screen identifies Elm1 as involved in the regulation of SBF by Cdc28. by Emily N. Manderson (272555)

“…Dark red indicates increase in PCA signal, dark blue indicates decrease in PCA signal, and black represents no change in PCA signal in a deletion strain relative to <i>MatA</i>. …”

Multiple regions of the p14 endodomain affect <i>trans</i>-enhancing activity. by Deniz Top (43453)

“…These endodomain alanine mutants (numbered 1–23) were co-expressed with authentic p14 in co-transfected QM5 cells, and the relative fusion level±S.E. (n = 4) was determined as described in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1000331#ppat-1000331-g001" target="_blank">Figure 1C</a>. …”

Morpholino knock down of kermit2 inhibits gastrulation and FN matrix assembly. by Erin Spicer (248823)

“…Embryos injected with 20 ng of Kermit2 5 mismatch control morpholino (COMO; B) gastrulate normally, and (E) exhibit a small decrease in FN matrix assembly. …”

Relationships between changes in biomarker levels and symptoms. by Angela M. Boutté (7224308)

“…<p>The change (delta (d) = post pre) in biomarker levels were compared to symptomology standardized as binary values. Data is displayed as a box plot (median + 5–95%-ile range) for the content of each biomarker (x-axis) among participants who reported no change or a decrease (grey, -) compared to an increase (red, +) in headaches, dizziness or taking longer to think (y-axis). …”

Cell content predictions derived from microarray data match known relationships between subject variables and brain tissue cell content. by Megan Hastings Hagenauer (5523191)

“…</b> Age was associated with a decrease in the neuronal indices (p = 0.000956) which fits known decreases in gray matter density in the frontal cortex in aging humans [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0200003#pone.0200003.ref047" target="_blank">47</a>]. …”

The Yeast Rab GTPase Ypt1 Modulates Unfolded Protein Response Dynamics by Regulating the Stability of <em>HAC1</em> RNA by Nikoleta G. Tsvetanova (149142)

“…Decreasing expression of the Ypt1 protein resulted in a reduced rate of <em>HAC1</em> RNA decay, leading to significantly increased levels of both unspliced and spliced <em>HAC1</em> RNA, and delayed attenuation of the UPR, when ER stress was relieved. …”

Anthropogenic CO2–induced seawater acidification driven the biogeochemical processes of dimethylsulfide in Northwestern Pacific marginal seas by Xuxu Gao (9724883)

“…Low pH can also suppress DMS biological production and microbial consumption rates and increase DMS photolysis rate, resulting in lower DMS emissions. We estimated that the decreased DMS emission caused by seawater acidification, would account for up to 35% of DMS flux in the marginal seas under the RCP8.5 high-emission scenario. …”

Experiment 2. by Lalit Pandey (13195488)

“…<p><b>(A)</b> We increased the number of hardcoded spatial operations by adding more layers to the CNN architecture. …”

Tether formation in networks with lower connectivity. by Chrysovalantou Kalaitzidou (18946434)

“…<p>Simulations with two cells contracting at 50% with Family-1 model λ − 1 (a-f) and Family-2 model λ⁷ − λ⁵ (g-p). …”

Spatial and temporal dynamics of shifting cultivation in the middle-Amazonas river: Expansion and intensification by Catarina Conte Jakovac (4261894)

“…We found that fallow-period length has decreased from 6.4 to 5.1 years on average, and that expansion over old-growth forest has slowed down over time. …”

Alterations in the <em>Aedes aegypti</em> Transcriptome during Infection with West Nile, Dengue and Yellow Fever Viruses by Tonya M. Colpitts (177569)

“…We identified 203 mosquito genes that were ≥5-fold differentially up-regulated (DUR) and 202 genes that were ≥10-fold differentially down-regulated (DDR) during infection with one of the three flaviviruses. …”

DataSheet_1_Lyl1-deficiency promotes inflammatory responses and increases mycobacterial burden in response to Mycobacterium tuberculosis infection in mice.pdf by Shelby-Sara Jones (10794980)

“…We report that Lyl1 downregulation upon immune stimulation is a host-driven process regulated by NFκB and MAP kinase pathways. …”