A putative model for the molecular pathway linking hypoxic stress to decreased AQP5 expression. by Jitesh D. Kawedia (384551)

LD- and haplotype-based measures of epistasis identify a narrow time window of epistasis detectability. by Gabriele Pedruzzi (5753792)

Detection of epistasis is confined in a time window whose width is controlled by the mean selection coefficient. by Gabriele Pedruzzi (5753792)

Fig 5 - by Pierre Bauvin (18154818)

Hypoxia induced decreases in dendritic spine density, length, soma size and volume of the apical and basal branches of CA1 and CA3 pyramidal neurons. by Chun-Sing Lam (695733)

Cyclosporine Inhibits a Direct Interaction between Cyclophilins and Hepatitis C NS5A by Fiona Fernandes (251389)

“…Mutations in NS5A alone conferred decreased CsA susceptibility regardless of NS5B mutations.…”

Mutation of four arginine residues in P34 leads to a decrease in binding between P34 and L5. by Anyango D. Kamina (4034165)

Overview of study procedures. by Matthew G. Vinson (22593374)

“…VIDEO and CONTROL were associated with a similar rise in intent to decrease OTC NSAID use (1.92 (SD: 4.41) vs. 1.36 (SD: 3.46), p = 0.150) and a similar decrease in NSAIDs exposure (−32.8% in VIDEO and −36.5% in CONTROL, p = 0.520) 4 weeks post-intervention. …”

Expanding Three-Coordinate Gold(I) Anticancer Agent Chemical Space by Charles E. Greif (21728091)

“…We report the synthesis and characterization of 14 complexes of the type (Au(R)[N̂N])⁺, where R = tunable biaryldialkyl phosphine ligands and [N̂N] = bidentate phenanthroline derivatives as anticancer agents. …”

AUC statistics as calculated from simulated time series. Each statistical metric was calculated within sliding windows, throughout the pre-critical interval. We considered five-, fifteen-, and thirty-day sliding windows. Given that the temperature of the system increased to 12°C on day sixty, we also considered three pre-critical intervals: Days 1 to 60, Days 20 to 60, and Days 30 to 60. To evaluate trends in these metrics, we calculated Kendall’s rank correlation coefficient during the pre-critical interval, and compared control (constant temperature, non-epidemic) and warming (warming treatment, epidemic emergence) coefficients across simulations and experimental populations by calculating the area under the curve (AUC) statistic. Values less than 0.5 suggest that a decrease in the statistical metric indicates emergence, while values greater than 0.5 suggest that an increase in the statistical metric indicates emergence, with more extreme values indicating stronger tre by Madeline Jarvis-Cross (22394247)

“…Values less than 0.5 suggest that a decrease in the statistical metric indicates emergence, while values greater than 0.5 suggest that an increase in the statistical metric indicates emergence, with more extreme values indicating stronger tre</p>…”

Meltrin β does not affect the expression of EphA4 on the cell surface nor the initial association between ephrin-A5 and EphA4, but decreases accessibility of antibodies that recognize the EphA4 C-terminus. by Norihiro Yumoto (270290)

Subjects:

S5 Fig - by Jordan K. Abbott (8934239)

Inactivation of the <i>WNT5A</i> Alternative Promoter B Is Associated with DNA Methylation and Histone Modification in Osteosarcoma Cell Lines U2OS and SaOS-2 by Himani Vaidya (3179403)

“…In this study, we analyzed expression from two of the major <i>WNT5A</i> promoters, termed promoter A and promoter B, in normal human osteoblasts, SaOS-2 and U2OS osteosarcoma cell lines, and osteosarcoma tumor tissue. …”

The effect of HA digestion and HA replenishment alone or with CS on barrier function measured by TEER. by Charlotte J. van Ginkel (20790466)

“…<p>(A) A steady increase in TEER is seen in differentiated porcine urothelial cells, corresponding with a tight epithelium and reaching the upper reliable limit of the equipment (3300 Ω cm²) around day 35. …”

Image 5_Deciphering the oncogenic network: how C1QTNF1-AS1 modulates osteosarcoma through miR-34a-5p and glycolytic pathways.tif by Yu Zhang (12946)

“…</p>Discussion<p>Our research emphasizes the critical role of C1QTNF1-AS1 in the pathogenesis of osteosarcoma (OS). We discovered that the downregulation of C1QTNF1-AS1 indirectly upregulates the expression of LDHA and PDK3 by suppressing miR-34a-5p, which functions as a regulator of the Warburg effect. …”

Table 5_Deciphering the oncogenic network: how C1QTNF1-AS1 modulates osteosarcoma through miR-34a-5p and glycolytic pathways.doc by Yu Zhang (12946)

“…</p>Discussion<p>Our research emphasizes the critical role of C1QTNF1-AS1 in the pathogenesis of osteosarcoma (OS). We discovered that the downregulation of C1QTNF1-AS1 indirectly upregulates the expression of LDHA and PDK3 by suppressing miR-34a-5p, which functions as a regulator of the Warburg effect. …”

Inhibition of G9a decreases the tumorigenicity of neuroblastoma cells. by Xiao-Xue Ke (626989)

Dual biomarkers long non-coding RNA GAS5 and microRNA-34a co-expression signature in common solid tumors by Eman A. Toraih (2589844)

“…<div><p>Accumulating evidence indicates that non-coding RNAs including microRNAs (miRs) and long non-coding RNAs (lncRNAs) are aberrantly expressed in cancer, providing promising biomarkers for diagnosis, prognosis and/or therapeutic targets. We aimed in the current work to quantify the expression profile of miR-34a and one of its bioinformatically selected partner lncRNA growth arrest-specific 5 (GAS5) in a sample of Egyptian cancer patients, including three prevalent types of cancer in our region; renal cell carcinoma (RCC), glioblastoma (GB), and hepatocellular carcinoma (HCC) as well as to correlate these expression profiles with the available clinicopathological data in an attempt to clarify their roles in cancer. …”

Optical Effects of <i>S</i>-Oxidation and M^<i>n</i>+ Binding in <i>meso</i>-Thienyl Dipyrrin Systems and of Stepwise Bromination of 4,4-Difluoro-8-(2,5-dibromo-3-thienyl... by Shin Hei Choi (2190841)

“…Treatment of 4,4-difluoro-8-(2,5-dibromo-3-thienyl)-4-bora-3<i>a</i>,4<i>a</i>-diaza-<i>s</i>-indacene with Br₂ gave red-shifted UV−vis absorption band features that grow with increasing dipyrrin bromination. …”

Optical Effects of <i>S</i>-Oxidation and M^<i>n</i>+ Binding in <i>meso</i>-Thienyl Dipyrrin Systems and of Stepwise Bromination of 4,4-Difluoro-8-(2,5-dibromo-3-thienyl... by Shin Hei Choi (2190841)

“…Treatment of 4,4-difluoro-8-(2,5-dibromo-3-thienyl)-4-bora-3<i>a</i>,4<i>a</i>-diaza-<i>s</i>-indacene with Br₂ gave red-shifted UV−vis absorption band features that grow with increasing dipyrrin bromination. …”