Pre-treatment with HMGB1 enhanced KA-induced up-regulation of P-gp in the epileptic brain. by Yan Chen (4308)

“…HMGB1 injection enhanced the over-expression of P-gp in the EP group mice while BoxA attenuated it. Scale bar: 50 μm. NS: normal saline control group; EP: KA-induced epileptic seizure group; EP+HMGB1: EP group pretreated with HMGB1; EP+BoxA: EP group pretreated with BoxA. …”

DataSheet_1_Insulin-like growth factor binding protein 5b of Trachinotus ovatus and its heparin-binding motif play a critical role in host antibacterial immune responses via NF-κB... by Hehe Du (14612936)

“…In contrast, TroIGFBP5b knockdown significantly decreased this ability. …”

Table_5_Metabolomic Response of Equine Skeletal Muscle to Acute Fatiguing Exercise and Training.xlsx by Dylan J. Klein (8460669)

“…<p>The athletic horse, despite being over 50% muscle mass, remains understudied with regard to the effects of exercise and training on skeletal muscle metabolism. …”

Table 1_Cdk5 mediates impaired autophagy by regulating NGF/Sirt1 axis to cause diabetic islet β cell damage.docx by Yuejia Tao (22406785)

“…NGF knockdown was associated with Sirt1 downregulation, while its overexpression upregulated Sirt1, restored autophagy, indicating that NGF positively regulates Sirt1 in islet β cells. Finally, we found that the NGF inhibitor K252a attenuated the protective effect of Lv-Cdk5 shRNA against high glucose-induced islet β cell injury in a mouse model. …”

Stereospecific CO₂ Copolymers from 3,5-Dioxaepoxides: Crystallization and Functionallization by Ye Liu (296340)

“…Despite the tremendous progress this field has made, most of the CO₂-based polycarbonates are known to be amorphous, and their low thermal resistance makes them difficult to use as structural materials. Herein, we report the selective synthesis of highly isotactic CO₂ copolymers from <i>meso</i>-3,5-dioxaepoxides in perfectly alternating nature by the enantiopure dinuclear Co­(III)-complex-mediated desymmetrization copolymerization under mild conditions. …”

Arginine starvation impacts <i>C</i>. <i>trachomatis</i> development in HeLa and C33A cells to an equivalent extent. by Shardulendra P. Sherchand (3133677)

Pyrethroid resistance alters the blood-feeding behavior in Puerto Rican <i>Aedes aegypti</i> mosquitoes exposed to treated fabric by Natasha M. Agramonte (455230)

“…<div><p>Emerging insecticide resistance is a major issue for vector control. It decreases the effectiveness of insecticides, thereby requiring greater quantities for comparable control with a net increase in risk of disease resurgence, product cost, and damage risk to the ecosystem. …”

Identification of Specific Glycosyltransferases Involved in Flavonol Glucoside Biosynthesis in Ginseng Using Integrative Metabolite Profiles, DIA Proteomics, and Phylogenetic Analy... by Qinggang Yin (10052366)

“…MeJA induced transcripts of UGT73A18 and UGT74T4 by over fourfold, consistent with the decrease of kaempferol 3-<i>O</i>-glucoside, which indicated that these genes may be related to resisting adversity stress in ginseng. …”

Identification of Specific Glycosyltransferases Involved in Flavonol Glucoside Biosynthesis in Ginseng Using Integrative Metabolite Profiles, DIA Proteomics, and Phylogenetic Analy... by Qinggang Yin (10052366)

“…MeJA induced transcripts of UGT73A18 and UGT74T4 by over fourfold, consistent with the decrease of kaempferol 3-<i>O</i>-glucoside, which indicated that these genes may be related to resisting adversity stress in ginseng. …”

Identification of Specific Glycosyltransferases Involved in Flavonol Glucoside Biosynthesis in Ginseng Using Integrative Metabolite Profiles, DIA Proteomics, and Phylogenetic Analy... by Qinggang Yin (10052366)

“…MeJA induced transcripts of UGT73A18 and UGT74T4 by over fourfold, consistent with the decrease of kaempferol 3-<i>O</i>-glucoside, which indicated that these genes may be related to resisting adversity stress in ginseng. …”

Mesothelin downregulation is associated with CpG hypermethylation and mesothelin transfection restores sensitivity to of KLM-1-R to RG7787. by Kevin Hollevoet (710450)

Activity of anti-mesothelin, anti-CD25 and anti-CD71 immunotoxins in KLM-1 and KLM-1-R. by Kevin Hollevoet (710450)

“…Growth inhibition was evaluated with an ATP cell viability assay. With IC₅₀s below 10 ng/ml, KLM-1 is sensitive to the anti-mesothelin RITs, which is not the case for KLM-1-R (IC₅₀s > 1 μg/ml). 1 μg/ml LMB-2 decreased cell viability, indicating that this RIT concentration induces non-specific uptake. …”

Image 1_Knockdown ATG5 gene by rAAV9 alleviates doxorubicin-induced cardiac toxicity by inhibiting GATA4 autophagic degradation.jpeg by Ai-Li Xu (20622440)

“…These effects of DOX were partially alleviated by rAAV9 expressing shRNA-ATG5 and deteriorated by rAAV9-ATG5. We demonstrated that genetic ATG5 knockdown or autophagy inhibition by chemical inhibitors increased GATA4 protein expression, which was reduced by ATG5 overexpression or autophagy activator in vitro and in vivo, suggesting that ATG5-mediated autophagy promoted GATA4 degradation. …”

Rational Synthesis and Magnetic Properties of a Family of Low-Dimensional Heterometallic Cr−Mn Complexes Based on the Versatile Building Block [Cr(2,2‘-bipyridine)(CN)₄]... by Yuan-Zhu Zhang (1711681)

“…All of the chain compounds exhibit metamagnetic behaviors with different critical temperatures (<i>T</i>_c) and critical fields (<i>H</i>_c; at 1.8 K):  3.2 K and 3.0 kOe for <b>1</b>; 2.3 K and 4.0 kOe for <b>2</b>; 2.1 K and 1.0 kOe for <b>4</b>; and 4.7 K and 5.0 kOe for <b>5</b>, respectively. The noncentrosymmetric compound <b>2</b> is also a weak ferromagnet at low temperature because of spin canting. …”

Table_1_The Affinity of Hemoglobin for Oxygen Is Not Altered During COVID-19.DOCX by Thomas Gille (10584065)

“…The authors hypothesized that this phenomenon could result in a decreased oxygen (O₂) binding and lead to hemolytic anemia as well. …”

Image_3_The Affinity of Hemoglobin for Oxygen Is Not Altered During COVID-19.TIF by Thomas Gille (10584065)

“…The authors hypothesized that this phenomenon could result in a decreased oxygen (O₂) binding and lead to hemolytic anemia as well. …”

Table_2_The Affinity of Hemoglobin for Oxygen Is Not Altered During COVID-19.DOCX by Thomas Gille (10584065)

“…The authors hypothesized that this phenomenon could result in a decreased oxygen (O₂) binding and lead to hemolytic anemia as well. …”

Image_2_The Affinity of Hemoglobin for Oxygen Is Not Altered During COVID-19.TIF by Thomas Gille (10584065)

“…The authors hypothesized that this phenomenon could result in a decreased oxygen (O₂) binding and lead to hemolytic anemia as well. …”

Table_3_The Affinity of Hemoglobin for Oxygen Is Not Altered During COVID-19.DOCX by Thomas Gille (10584065)

“…The authors hypothesized that this phenomenon could result in a decreased oxygen (O₂) binding and lead to hemolytic anemia as well. …”

Image_4_The Affinity of Hemoglobin for Oxygen Is Not Altered During COVID-19.TIF by Thomas Gille (10584065)

“…The authors hypothesized that this phenomenon could result in a decreased oxygen (O₂) binding and lead to hemolytic anemia as well. …”