MCF7-luc-GFP-mCherry breast tumor response to administration of BPR0L075 observed by bioluminescence. by Li Liu (75607)

“…<p>(A, B) BLI of the same mouse as shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0043314#pone-0043314-g001" target="_blank">Figure 1</a> with images obtained within 15 mins after administration of luciferin s.c. immediately after the FLI; (C) Dynamic BLI showing evolution of signal intensity for the MCF7-luc-GFP-mCherry tumor shown in “A” over 40 minutes; respective curves show baseline (blue diamonds), together with 2 (red squares), 4 (green triangles), 6 (open circles) and 24 (yellow circles) hours after administration of drug carrier vehicle; (D) Dynamic BLI with respect to treatment with BPR0L075 (50 mg/kg i.p.): baseline (same as 24 hour time point in “A”, yellow circles); 2 hours after drug (red squares), 6 hours after drug (open circles) and 24 hours after drug (green triangles); (E) Normalized maximum bioluminescent signal observed in the first 15 mins post luciferin injection at each time point sequentially for individual mice over 24 hours with respect to carrier vehicle (n = 3, dashed lines) or drug (n = 3; solid lines). …”

Neither insulin nor VDAC modulate apoptosis triggered by detachment of HK II from mitochondria. by Federica Chiara (43469)

“…Cells were exposed for 1 hour to the stated concentrations of TAT-HK with or without pre-incubation with Debio 025 (DB, 8 µM), bongkrekate (BK, 100 µM) or Z.VAD-fmk (50 µM). Diagrams and percentages of the different cell populations are indicated as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0001852#pone-0001852-g001" target="_blank">Fig. 1B</a>. …”

Indexing from nucleotide to the codon. by Refat Khan Pathan (16871953)

“…Using this time series analysis method, the prospective mutation rate of the 50^th patient has been predicted. Note that this is a new report on the monkeypox gene mutation. …”

Image_2_Photosynthetic response of Chlamydomonas reinhardtii and Chlamydomonas sp. 1710 to zinc toxicity.TIF by Di Zhan (14842687)

“…The μ and Chl-a content of C. reinhardtii decreased in the presence of 15  mg/L Zn, whereas those of Chlamydomonas sp. 1710 were unaffected by as high as 100  mg/L Zn. …”

Endothelial progenitor cells in chronic obstructive pulmonary disease and emphysema by Margaret F. Doyle (449942)

“…<div><p>Endothelial injury is implicated in the pathogenesis of COPD and emphysema; however the role of endothelial progenitor cells (EPCs), a marker of endothelial cell repair, and circulating endothelial cells (CECs), a marker of endothelial cell injury, in COPD and its subphenotypes is unresolved. …”

Video_1_Activity-State Dependent Reversal of Ketamine-Induced Resting State EEG Effects by Clozapine and Naltrexone in the Freely Moving Rat.mp4 by Christien Bowman (12007985)

“…<p>Ketamine is a non-competitive N-Methyl-D-aspartate receptor (NMDAR) antagonist used in the clinic to initiate and maintain anaesthesia; it induces dissociative states and has emerged as a breakthrough therapy for major depressive disorder. …”

Image 1_Prognostic significance of calcium-related genes in lung adenocarcinoma and the role of TNNC1 in macrophage polarization and erlotinib resistance.jpeg by Jian Feng (317890)

“…Down-regulation of TNNC1 decreased the IC₅₀ value of erlotinib in LUAD cells and inhibited macrophage M2 polarization.…”

Data_Sheet_1_Different Amounts of Nitrogen Fertilizer Applications Alter the Bacterial Diversity and Community Structure in the Rhizosphere Soil of Sugarcane.docx by Yan Gu (125500)

“…Excessive application of N fertilizers significantly decreased the pH and increased the available N in soils and unexpectedly obtained a lower yield. …”

LM micrographs of annular appendage development. by Jianxia Li (5714774)

“…Scale bars: A, K, O, P = 100 μm; B, D, F, G, I, J, L, N = 20 μm; C, E, H, M = 50 μm. …”

Data Sheet 1_v3_Modulation of NMDA receptor activity by CR4056, an imidazoline-2 receptor ligand with analgesic properties.pdf by Giulia Puja (8696967)

“…In primary culture of cortical neurons, application of NMDA and glycine elicits a current that is decreased in a dose-dependent fashion by CR4056 (IC₅₀ 5.3 ± 0.1 µM). …”

Wheat germ agglutinin-nanoparticles encapsulating itacitinib target and suppress pro-inflammatory slan+ monocytes by Karen Alvarez (17620292)

“…<p>6-sulfoLacNAc (slan)+ monocytes, a non-classical monocyte subset, play a pro-inflammatory role in autoimmune diseases like systemic lupus erythematosus (SLE). …”

Video_3_Activity-State Dependent Reversal of Ketamine-Induced Resting State EEG Effects by Clozapine and Naltrexone in the Freely Moving Rat.mp4 by Christien Bowman (12007985)

“…<p>Ketamine is a non-competitive N-Methyl-D-aspartate receptor (NMDAR) antagonist used in the clinic to initiate and maintain anaesthesia; it induces dissociative states and has emerged as a breakthrough therapy for major depressive disorder. …”

Image_3_Photosynthetic response of Chlamydomonas reinhardtii and Chlamydomonas sp. 1710 to zinc toxicity.TIF by Di Zhan (14842687)

“…The μ and Chl-a content of C. reinhardtii decreased in the presence of 15  mg/L Zn, whereas those of Chlamydomonas sp. 1710 were unaffected by as high as 100  mg/L Zn. …”

Stages and differential expression of <i>Fundulus heteroclitus</i> embryos incubated in water or exposed to air. by Angèle Tingaud-Sequeira (417086)

“…<p>(<b>A</b>) Representative photomicrographs of mid-gastrula embryos (50% epiboly), and of developing embryos after 0.5, 1, 3, 6, 12 and 24 h of aerial incubation at ∼100% RH as indicated. …”

Image 1_Downregulated PTEN and aberrant JAK–STAT signal pathway in essential thrombocythemia patients.jpeg by Lin Luo (429475)

“…</p>Results<p>The results showed a downregulated PTEN expression in the BM-MNCs of patients with ET, as well as an elevated p-STAT3 expression and a decreased p-STAT5 expression. …”

Table_2_Photosynthetic response of Chlamydomonas reinhardtii and Chlamydomonas sp. 1710 to zinc toxicity.XLSX by Di Zhan (14842687)

“…The μ and Chl-a content of C. reinhardtii decreased in the presence of 15  mg/L Zn, whereas those of Chlamydomonas sp. 1710 were unaffected by as high as 100  mg/L Zn. …”

Datasheet1_Modulation of NMDA receptor activity by CR4056, an imidazoline-2 receptor ligand with analgesic properties.pdf by Giulia Puja (8696967)

“…In primary culture of cortical neurons, application of NMDA and glycine elicits a current that is decreased in a dose-dependent fashion by CR4056 (IC₅₀ 5.3 ± 0.1 µM). …”

Table 1_Downregulated PTEN and aberrant JAK–STAT signal pathway in essential thrombocythemia patients.docx by Lin Luo (429475)

“…</p>Results<p>The results showed a downregulated PTEN expression in the BM-MNCs of patients with ET, as well as an elevated p-STAT3 expression and a decreased p-STAT5 expression. …”

Table_1_Isolating High Antimicrobial Ability Lignin From Bamboo Kraft Lignin by Organosolv Fractionation.doc by Jinyan Yun (10226678)

“…Gel permeation chromatography (GPC) analysis showed that decreased molecular weight lignin fractions were obtained by sequentially organosolv fractionation with anhydrous acetone, 50% acetone and 37.5% hexanes. …”

HO-1 induction increases HO-1, AKT and GSK3β expression in diabetic hearts. by Yossi Issan (540887)

“…CoPP treatment led to an increase in GSK-3β levels; SnPP decreased GSK-3β expression compared to the CoPP treated diabetic mice (Means ± SD, n = 5. …”